PMID- 27370412
OWN - NLM
STAT- MEDLINE
DCOM- 20180309
LR  - 20181113
IS  - 1096-0929 (Electronic)
IS  - 1096-6080 (Print)
IS  - 1096-0929 (Linking)
VI  - 153
IP  - 2
DP  - 2016 Oct
TI  - Editor's Highlight: Transplacental and Lactational Transfer of Firemaster(R) 550 
      Components in Dosed Wistar Rats.
PG  - 246-57
LID - 10.1093/toxsci/kfw122 [doi]
AB  - Firemaster(R) 550 (FM 550) is a commercial mixture of organophosphate and 
      brominated flame retardants currently in use as a replacement for pentaBDE. Its 
      organophosphate components include triphenyl phosphate (TPHP) and a suite of 
      isopropylated triarylphosphate isomers (ITPs); its brominated components include 
      2-ethylhexyl-2,3,4,5-tetrabromobenzoate (EH-TBB) and bis 
      (2-ethylhexyl)-2,3,4,5-tetrabromophthalate (BEH-TEBP). Taken together, these 
      chemicals have been shown to be endocrine disrupting and potentially toxic, and 
      human exposure to them is widespread. In this study, maternal transfer of FM 550 
      components, and in some cases their metabolites, was investigated in dosed Wistar 
      rats. Gestational and lactational transfer were examined separately, with dams 
      orally exposed to 300 or 1000 microg of FM 550 for 10 consecutive days during 
      gestation (gestational day [GD] 9-18) or lactation (postnatal day [PND] 3-12). 
      Levels of parent compounds were measured in fetus and whole pup tissue 
      homogenates, and in dam and pup serum, and several metabolites were measured in 
      dam and pup urine. EH-TBB body burdens resulting from lactational transfer were 
      approximately 200- to 300-fold higher than those resulting from placental 
      transfer, whereas low levels of BEH-TEBP were transferred during both lactation 
      and gestation. TPHP and ITPs were rapidly metabolized by the dams and were not 
      detected in whole tissue homogenates. However, diphenyl phosphate (DPHP) and 
      mono-isopropylphenyl phenyl phosphate (ip-PPP) were detected in urine from the 
      dosed animals. This study is the first to confirm ip-PPP as a urinary metabolite 
      of ITPs and establish a pharmacokinetic profile of FM 550 in a mammalian model. 
      KEY WORDS: Firemaster 550 ;: lactational transfer ;: gestational transfer; 
      metabolites; rodent.
CI  - (c) The Author 2016. Published by Oxford University Press on behalf of the Society 
      of Toxicology. All rights reserved. For Permissions, please e-mail: 
      journals.permissions@oup.com.
FAU - Phillips, Allison L
AU  - Phillips AL
AD  - *Nicholas School of the Environment, Levine Science Research Center, Duke 
      University, Durham, North Carolina 27710;
FAU - Chen, Albert
AU  - Chen A
AD  - *Nicholas School of the Environment, Levine Science Research Center, Duke 
      University, Durham, North Carolina 27710;
FAU - Rock, Kylie D
AU  - Rock KD
AD  - Department of Biology, North Carolina State University, Raleigh, North Carolina, 
      27695.
FAU - Horman, Brian
AU  - Horman B
AD  - Department of Biology, North Carolina State University, Raleigh, North Carolina, 
      27695.
FAU - Patisaul, Heather B
AU  - Patisaul HB
AD  - Department of Biology, North Carolina State University, Raleigh, North Carolina, 
      27695.
FAU - Stapleton, Heather M
AU  - Stapleton HM
AD  - *Nicholas School of the Environment, Levine Science Research Center, Duke 
      University, Durham, North Carolina 27710; heather.stapleton@duke.edu.
LA  - eng
GR  - R56 ES022957/ES/NIEHS NIH HHS/United States
GR  - T32 ES021432/ES/NIEHS NIH HHS/United States
GR  - T32 ES007046/ES/NIEHS NIH HHS/United States
GR  - P30 ES025128/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20160630
PL  - United States
TA  - Toxicol Sci
JT  - Toxicological sciences : an official journal of the Society of Toxicology
JID - 9805461
RN  - 0 (Flame Retardants)
SB  - IM
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Flame Retardants/*pharmacokinetics
MH  - *Lactation
MH  - Male
MH  - *Maternal-Fetal Exchange
MH  - Placenta/*metabolism
MH  - Pregnancy
MH  - Rats
MH  - Rats, Wistar
PMC - PMC5036616
EDAT- 2016/07/03 06:00
MHDA- 2018/03/10 06:00
PMCR- 2017/10/01
CRDT- 2016/07/03 06:00
PHST- 2016/07/03 06:00 [entrez]
PHST- 2016/07/03 06:00 [pubmed]
PHST- 2018/03/10 06:00 [medline]
PHST- 2017/10/01 00:00 [pmc-release]
AID - kfw122 [pii]
AID - 10.1093/toxsci/kfw122 [doi]
PST - ppublish
SO  - Toxicol Sci. 2016 Oct;153(2):246-57. doi: 10.1093/toxsci/kfw122. Epub 2016 Jun 
      30.