PMID- 27373288
OWN - NLM
STAT- MEDLINE
DCOM- 20170110
LR  - 20191210
IS  - 0578-1426 (Print)
IS  - 0578-1426 (Linking)
VI  - 55
IP  - 7
DP  - 2016 Jul 1
TI  - [The application of matrix metalloproteinase-3 and 7 joints ultrasonic score in 
      assessment of disease activity in patients with rheumatoid arthritis].
PG  - 531-4
LID - 10.3760/cma.j.issn.0578-1426.2016.07.009 [doi]
AB  - OBJECTIVE: To evaluate the significance of serum matrix metalloproteinase-3 
      (MMP-3) and joint ultrasonography in assessing the activity of rheumatoid 
      arthritis (RA) by comparing MMP-3 level and the ultrasonic 7 joints (US7) score 
      in RA patients. METHODS: Serum MMP-3 level and US7 score were measured in 133 RA 
      patients by immune turbidity and Doppler ultrasound. Synchronous 53 healthy 
      subjects were recruited as controls. Clinical data were collected. Erythrocyte 
      sedimentation rate (ESR), serum level of anti-cyclic citrullinated peptide (CCP) 
      antibody, health assessment questionnaire (HAQ) and disease activity score 28 
      (DAS28) were measured. The level of disease activity is interpreted as 
      remission(DAS28<2.6), low(DAS 28>/=2.6-<3.2), moderate(DAS 28>/=3.2-<5.1), 
      high(DAS28>/=5.1). The discriminating validity of MMP-3 and US7 score in disease 
      was evaluated using receiver operating characteristic (ROC) curve analysis with 
      DAS28 as the reference standard. RESULTS: Compared with that in healthy controls 
      [35.20(25.90, 48.90) mug/L] and remission patients[33.40(22.60, 678.40) mug/L], the 
      MMP-3 level in moderate [105.1(61.70, 172.70) mug/L] and high [363.1(161.50, 
      475.90) mug/L] groups increased dramatically. US7 score in patients with high 
      disease activity was significantly higher than that in other groups. The level of 
      MMP-3 was significantly correlated with DAS28, HAQ, US7 score, yet did not have 
      correlation with anti-CCP antibody. Serum level of MMP-3 was positively 
      correlated with US7 score(r=0.566, P<0.001). In evaluating the disease activity, 
      US7 score combined with MMP-3 (AUC 0.863 2) was not superior to MMP-3 alone (AUC 
      0.854 3), but significantly better than single US7 score (AUC 0.764 3, P<0.05). 
      CONCLUSIONS: MMP-3 is an effective and simple index in evaluating RA disease 
      activity. The combination of MMP-3 and US7 score does not further improve the 
      efficacy to evaluate disease activity than MMP-3 alone in patients with RA.
FAU - Zhou, L
AU  - Zhou L
AD  - Department of Rheumatology, Changzheng Hospital, Second Military Medical 
      University, Shanghai 200003, China.
FAU - Song, J
AU  - Song J
FAU - Chen, L
AU  - Chen L
FAU - Xu, H J
AU  - Xu HJ
LA  - chi
PT  - Evaluation Study
PT  - Journal Article
PL  - China
TA  - Zhonghua Nei Ke Za Zhi
JT  - Zhonghua nei ke za zhi
JID - 16210490R
RN  - 0 (Autoantibodies)
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - EC 3.4.24.23 (MMP7 protein, human)
RN  - EC 3.4.24.23 (Matrix Metalloproteinase 7)
SB  - IM
MH  - Arthritis, Rheumatoid/blood/*diagnostic imaging
MH  - Autoantibodies/*blood
MH  - Blood Sedimentation
MH  - Case-Control Studies
MH  - Humans
MH  - Matrix Metalloproteinase 3/*blood/metabolism
MH  - Matrix Metalloproteinase 7/*blood/metabolism
MH  - ROC Curve
MH  - Ultrasonics
EDAT- 2016/07/05 06:00
MHDA- 2017/01/11 06:00
CRDT- 2016/07/05 06:00
PHST- 2016/07/05 06:00 [entrez]
PHST- 2016/07/05 06:00 [pubmed]
PHST- 2017/01/11 06:00 [medline]
AID - 10.3760/cma.j.issn.0578-1426.2016.07.009 [doi]
PST - ppublish
SO  - Zhonghua Nei Ke Za Zhi. 2016 Jul 1;55(7):531-4. doi: 
      10.3760/cma.j.issn.0578-1426.2016.07.009.