PMID- 27373450
OWN - NLM
STAT- MEDLINE
DCOM- 20170724
LR  - 20180302
IS  - 1932-8494 (Electronic)
IS  - 1932-8486 (Linking)
VI  - 299
IP  - 9
DP  - 2016 Sep
TI  - Effect of Potassium Bromate on the Liver of Adult Male Albino Rat and A Possible 
      Protective Role of Vitamin C: Histological, Immunohistochemical, and Biochemical 
      Study.
PG  - 1256-69
LID - 10.1002/ar.23386 [doi]
AB  - Potassium bromate (KBrO3 ) is a food additive which is used primarily as a 
      maturing agent for flour. It is proved as a toxic agent with significant 
      reduction in the activities of antioxidant capacity. The therapeutic efficacy of 
      vitamin C as antioxidant may provide a possible solution to KBrO3 mediated 
      oxidative damage. Twenty four adult male albino rats were used to evaluate the 
      protective role of vitamin C against KBrO3 induced hepatotoxicity and divided 
      into four groups; Group 1 (control), Group 2: received 30 mg/Kg/day vitamin C 
      orally for 4 weeks, Group 3: received 20 mg/Kg/dose KBrO3 orally twice weekly for 
      4 weeks and Group 4: received both KBrO3 and vitamin C. Liver specimens were 
      processed for histological study by light and electron microscopes and stained 
      immunohistochemically to detect glial fibriller acidic protein (GFAP). Serum 
      levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) 
      were estimated as well as the levels of malondialdehyde (MDA), glutathione (GSH) 
      and superoxide dismutase (SOD) activities in all dissected tissues were 
      determined. KBrO3 induced histological alterations in the form of degeneration, 
      cellular infiltration and significant increase in collagen deposition in portal 
      tracts with a significant increase in immunoexpression of GFAP. Significant rise 
      in serum levels of AST, ALT, and MDA in liver tissues were recorded. However, 
      levels of GSH and SOD were significantly decreased. Most of these changes were 
      improved by vitamin C treatment. In conclusion, vitamin C ameliorates the 
      histological and biochemical alterations of the liver induced by KBrO3 . Anat 
      Rec, 299:1256-1269, 2016. (c) 2016 Wiley Periodicals, Inc.
CI  - (c) 2016 Wiley Periodicals, Inc.
FAU - Bayomy, Naglaa A
AU  - Bayomy NA
AD  - Histology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
FAU - Soliman, Gehan M
AU  - Soliman GM
AD  - Histology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
FAU - Abdelaziz, Eman Z
AU  - Abdelaziz EZ
AD  - Pharmacology department, Faculty of Medicine, Ismalia University, Suez Canal, 
      Egypt.
LA  - eng
PT  - Journal Article
DEP - 20160713
PL  - United States
TA  - Anat Rec (Hoboken)
JT  - Anatomical record (Hoboken, N.J. : 2007)
JID - 101292775
RN  - 0 (Antioxidants)
RN  - 0 (Bromates)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 04MB35W6ZA (potassium bromate)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
RN  - GAN16C9B8O (Glutathione)
RN  - PQ6CK8PD0R (Ascorbic Acid)
SB  - IM
MH  - Alanine Transaminase/blood
MH  - Animals
MH  - Antioxidants/*pharmacology
MH  - Ascorbic Acid/*pharmacology
MH  - Aspartate Aminotransferases/blood
MH  - Bromates/*pharmacology
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - Glutathione/metabolism
MH  - Liver/*drug effects/metabolism
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Oxidative Stress/*drug effects
MH  - Rats
MH  - Superoxide Dismutase/metabolism
OTO - NOTNLM
OT  - GFAP
OT  - liver
OT  - potassium bromate
OT  - vitamin C
EDAT- 2016/07/05 06:00
MHDA- 2017/07/25 06:00
CRDT- 2016/07/05 06:00
PHST- 2016/03/02 00:00 [received]
PHST- 2016/04/20 00:00 [accepted]
PHST- 2016/07/05 06:00 [entrez]
PHST- 2016/07/05 06:00 [pubmed]
PHST- 2017/07/25 06:00 [medline]
AID - 10.1002/ar.23386 [doi]
PST - ppublish
SO  - Anat Rec (Hoboken). 2016 Sep;299(9):1256-69. doi: 10.1002/ar.23386. Epub 2016 Jul 
      13.