PMID- 27374075
OWN - NLM
STAT- MEDLINE
DCOM- 20170630
LR  - 20231111
IS  - 1582-4934 (Electronic)
IS  - 1582-1838 (Print)
IS  - 1582-1838 (Linking)
VI  - 20
IP  - 11
DP  - 2016 Nov
TI  - Genetic variants of nuclear factor erythroid-derived 2-like 2 associated with the 
      complications in Han descents with type 2 diabetes mellitus of Northeast China.
PG  - 2078-2088
LID - 10.1111/jcmm.12900 [doi]
AB  - The transcription factor nuclear factor erythroid 2-like 2 (NFE2L2) is essential 
      for preventing type 2 diabetes mellitus (T2DM)-induced complications in animal 
      models. This case and control study assessed genetic variants of NFE2L2 for 
      associations with T2DM and its complications in Han Chinese volunteers. T2DM 
      patients with (n = 214) or without (n = 236) complications, or healthy controls 
      (n = 359), were genotyped for six NFE2L2 single nucleotide polymorphisms (SNPs: 
      rs2364723, rs13001694, rs10497511, rs1806649, rs1962142 and rs6726395) with 
      TaqMan Pre-Designed SNP Genotyping and Sequence System. Serum levels of heme 
      oxygenase-1 (HMOX1) were determined through enzyme-linked immunosorbent assay. 
      Informative data were obtained for 341 cases and 266 controls. Between T2DM 
      patients and controls, the genotypic and allelic frequencies and haplotypes of 
      the SNPs were similar. However, there was a significant difference in genotypic 
      and allelic frequencies of rs2364723, rs10497511, rs1962142 and rs6726395 between 
      T2DM patients with and without complications, including peripheral neuropathy, 
      nephropathy, retinopathy, foot ulcers and microangiopathy. Furthermore, HMOX1 
      levels were significantly higher in T2DM patients with complications than in 
      controls. Multiple logistic regression analysis, however, showed that only 
      rs2364723 significantly reduced levels of serum HMOX1 in T2DM patients for the GG 
      genotype carriers compared with participants with CG+CC genotype. The data 
      suggest that although NFE2L2 rs2364723, rs10497511, rs1962142 and rs6726395 were 
      not associated with T2DM risk, they were significantly associated with 
      complications of T2DM. In addition, only for rs2364723 higher serum HMOX1 levels 
      were found in the T2DM patients with CG+CC than those with GG genotype.
CI  - (c) 2016 The Authors. Journal of Cellular and Molecular Medicine published by John 
      Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.
FAU - Xu, Xiaohong
AU  - Xu X
AD  - Department of Gynecology and Obstetrics, Second Hospital of Jilin University, 
      Changchun, China.
FAU - Sun, Jing
AU  - Sun J
AD  - Department of Nephropathy, Second Hospital of Jilin University, Changchun, China.
FAU - Chang, Xiaomin
AU  - Chang X
AD  - Department of Nephropathy, Second Hospital of Jilin University, Changchun, China.
FAU - Wang, Ji
AU  - Wang J
AD  - Department of Nephropathy, Second Hospital of Jilin University, Changchun, China.
FAU - Luo, Manyu
AU  - Luo M
AD  - Department of Nephropathy, Second Hospital of Jilin University, Changchun, China.
AD  - Kosair Children's Hospital Research Institute, Department of Pediatrics, 
      University of Louisville, Louisville, KY, USA.
FAU - Wintergerst, Kupper A
AU  - Wintergerst KA
AD  - Kosair Children's Hospital Research Institute, Department of Pediatrics, 
      University of Louisville, Louisville, KY, USA.
AD  - Division of Endocrinology, Department of Pediatrics, University of Louisville, 
      Louisville, KY, USA.
AD  - Wendy L. Novak Diabetes Care Center, Kosair Children's Hospital, University of 
      Louisville, Louisville, KY, USA.
FAU - Miao, Lining
AU  - Miao L
AD  - Department of Nephropathy, Second Hospital of Jilin University, Changchun, China. 
      miaolining55@163.com.
FAU - Cai, Lu
AU  - Cai L
AD  - Kosair Children's Hospital Research Institute, Department of Pediatrics, 
      University of Louisville, Louisville, KY, USA. L0cai001@louisville.edu.
AD  - Wendy L. Novak Diabetes Care Center, Kosair Children's Hospital, University of 
      Louisville, Louisville, KY, USA. L0cai001@louisville.edu.
LA  - eng
PT  - Journal Article
DEP - 20160704
PL  - England
TA  - J Cell Mol Med
JT  - Journal of cellular and molecular medicine
JID - 101083777
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (NFE2L2 protein, human)
RN  - EC 1.14.14.18 (HMOX1 protein, human)
RN  - EC 1.14.14.18 (Heme Oxygenase-1)
SB  - IM
MH  - Case-Control Studies
MH  - China
MH  - Demography
MH  - Diabetes Mellitus, Type 2/blood/*complications/*genetics
MH  - Ethnicity/*genetics
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Haplotypes/genetics
MH  - Healthy Volunteers
MH  - Heme Oxygenase-1/blood
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - NF-E2-Related Factor 2/*genetics
MH  - Polymorphism, Single Nucleotide/*genetics
PMC - PMC5082403
OTO - NOTNLM
OT  - Chinese population
OT  - NFE2L2 gene mutation
OT  - Nrf2 polymorphism
OT  - diabetes
OT  - diabetic complications
EDAT- 2016/10/27 06:00
MHDA- 2017/07/01 06:00
PMCR- 2016/11/01
CRDT- 2016/07/05 06:00
PHST- 2015/11/29 00:00 [received]
PHST- 2016/05/10 00:00 [accepted]
PHST- 2016/10/27 06:00 [pubmed]
PHST- 2017/07/01 06:00 [medline]
PHST- 2016/07/05 06:00 [entrez]
PHST- 2016/11/01 00:00 [pmc-release]
AID - JCMM12900 [pii]
AID - 10.1111/jcmm.12900 [doi]
PST - ppublish
SO  - J Cell Mol Med. 2016 Nov;20(11):2078-2088. doi: 10.1111/jcmm.12900. Epub 2016 Jul 
      4.