PMID- 27375186
OWN - NLM
STAT- MEDLINE
DCOM- 20170327
LR  - 20201218
IS  - 1747-0803 (Electronic)
IS  - 1747-079X (Linking)
VI  - 12
IP  - 1
DP  - 2017 Jan
TI  - Bicuspid and Unicuspid Aortic Valve: Fate of Moderate/Severe Mixed Aortic Valve 
      Disease.
PG  - 24-31
LID - 10.1111/chd.12391 [doi]
AB  - OBJECTIVES: There is a paucity of data about mixed aortic valve disease (MAVD) in 
      patients with bicuspid/unicuspid aortic valve (BAV). This study sought to 
      describe the outcomes of patients with moderate/severe MAVD. METHODS: We queried 
      our database for patients with BAV and moderate/severe MAVD seen between 1994 and 
      2013. We excluded patients with baseline New York Heart Association (NYHA) III/IV 
      symptoms, left ventricular ejection fraction <50%, aortic dimension >50 mm, and 
      significant disease of other valves. The purpose of the study was to determine 
      the freedom from NYHA III/IV symptoms and aortic valve replacement (AVR). 
      RESULTS: We identified 138 patients with moderate/severe MAVD; mean age was 
      51 +/- 12 years; 112 (81%) were males; and follow-up was 8.5 +/- 4 years. Ninety-two 
      patients (67%) underwent AVR within 3.7 +/- 2.5 years. Mechanical prostheses were 
      implanted in 73 patients (79%); 22 patients (26%) and 36 patients (39%) had 
      concomitant coronary artery bypass graft and aorta replacement during AVR 
      respectively. There were no surgical deaths. Freedom from AVR was 84%, 51%, and 
      20% at 1, 5 and 10 years respectively. Predictors of AVR were age at presentation 
      (hazard ratio [HR] 5.22; confidence interval [CI] 3.10 to 6.64) for every decade 
      increase in age; and having severe stenosis or regurgitation at the time of 
      presentation (HR 1.32; CI 1.05 to 3.16). CONCLUSIONS: Age and disease severity 
      should be incorporated in the risk assessment of BAV patients with MAVD, and 
      patients with both risk factors should be monitored closely.
CI  - (c) 2016 Wiley Periodicals, Inc.
FAU - Egbe, Alexander C
AU  - Egbe AC
AD  - Divisions of *Cardiovascular Diseases, Mayo Clinic Rochester, Minn, USA.
FAU - Connolly, Heidi M
AU  - Connolly HM
AD  - Divisions of *Cardiovascular Diseases, Mayo Clinic Rochester, Minn, USA.
FAU - Poterucha, Joseph T
AU  - Poterucha JT
AD  - Divisions of *Cardiovascular Diseases, Mayo Clinic Rochester, Minn, USA.
AD  - Pediatric Cardiology, Mayo Clinic Rochester, Minn, USA.
FAU - Warnes, Carole A
AU  - Warnes CA
AD  - Divisions of *Cardiovascular Diseases, Mayo Clinic Rochester, Minn, USA.
LA  - eng
PT  - Journal Article
DEP - 20160704
PL  - United States
TA  - Congenit Heart Dis
JT  - Congenital heart disease
JID - 101256510
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aortic Valve/*abnormalities/physiopathology/surgery
MH  - Aortic Valve Insufficiency/etiology/mortality/physiopathology/*surgery
MH  - Aortic Valve Stenosis/etiology/mortality/physiopathology/*surgery
MH  - Bicuspid Aortic Valve Disease
MH  - Databases, Factual
MH  - Disease-Free Survival
MH  - Female
MH  - Heart Valve Diseases/complications/mortality/physiopathology/*surgery
MH  - Heart Valve Prosthesis
MH  - *Heart Valve Prosthesis Implantation/adverse effects/instrumentation/mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Minnesota
MH  - Postoperative Complications/etiology
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Time Factors
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Aortic Regurgitation
OT  - Aortic Stenosis
OT  - Aortic Valve Replacement
OT  - Bicuspid Valve
EDAT- 2016/07/05 06:00
MHDA- 2017/03/28 06:00
CRDT- 2016/07/05 06:00
PHST- 2016/06/06 00:00 [accepted]
PHST- 2016/07/05 06:00 [pubmed]
PHST- 2017/03/28 06:00 [medline]
PHST- 2016/07/05 06:00 [entrez]
AID - 10.1111/chd.12391 [doi]
PST - ppublish
SO  - Congenit Heart Dis. 2017 Jan;12(1):24-31. doi: 10.1111/chd.12391. Epub 2016 Jul 
      4.