PMID- 2737545
OWN - NLM
STAT- MEDLINE
DCOM- 19890803
LR  - 20180217
IS  - 0378-7346 (Print)
IS  - 0378-7346 (Linking)
VI  - 27
IP  - 3
DP  - 1989
TI  - The source of immunoglobulin E in the fetus at term.
PG  - 129-32
AB  - A high level of immunoglobulin E (IgE) in cord blood (CB) is well known to be 
      predictive of the development of clinical allergy during early childhood. We have 
      tried to ascertain the source of IgE in cord blood by carrying out a series of 
      measurements of IgE concentrations in arterial and venous CB of newborns and 
      comparing them to IgE concentrations in blood samples from both parents. We found 
      that the concentrations of IgE in arterial and venous CB were almost completely 
      identical in the 131 newborns examined whereas IgD concentrations were 
      significantly higher in arterial than in venous CB. Moderate but significant 
      positive correlations were found between IgE concentrations in maternal blood and 
      CB; paternal blood and CB; and maternal and paternal blood. Our data suggest that 
      CB-IgE is essentially a product of fetal lymphocytes. The positive correlations 
      found between the IgE blood concentrations in the newborns, the mothers and the 
      fathers, is most likely an effect of the amount and nature of the allergenic 
      constituents in the family environment.
FAU - Schreyer, P
AU  - Schreyer P
AD  - Department of Obstetrics and Gynecology, Assaf Harofe Medical Center, Zerifin, 
      Israel.
FAU - Avrech, O
AU  - Avrech O
FAU - Caspi, E
AU  - Caspi E
FAU - Samra, Z
AU  - Samra Z
FAU - Sompolinsky, D
AU  - Sompolinsky D
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Switzerland
TA  - Gynecol Obstet Invest
JT  - Gynecologic and obstetric investigation
JID - 7900587
RN  - 0 (Immunoglobulin D)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Amniotic Fluid/analysis
MH  - Arteries
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Fathers
MH  - Female
MH  - Fetal Blood/*analysis
MH  - Humans
MH  - Immunoglobulin D/analysis
MH  - Immunoglobulin E/*analysis
MH  - Male
MH  - Mothers
MH  - Pregnancy
MH  - Radioimmunosorbent Test
MH  - Veins
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - 10.1159/000293638 [doi]
PST - ppublish
SO  - Gynecol Obstet Invest. 1989;27(3):129-32. doi: 10.1159/000293638.