PMID- 27375781
OWN - NLM
STAT- MEDLINE
DCOM- 20171030
LR  - 20240325
IS  - 1838-7640 (Electronic)
IS  - 1838-7640 (Linking)
VI  - 6
IP  - 9
DP  - 2016
TI  - The Smart Drug Delivery System and Its Clinical Potential.
PG  - 1306-23
LID - 10.7150/thno.14858 [doi]
AB  - With the unprecedented progresses of biomedical nanotechnology during the past 
      few decades, conventional drug delivery systems (DDSs) have been involved into 
      smart DDSs with stimuli-responsive characteristics. Benefiting from the response 
      to specific internal or external triggers, those well-defined nanoplatforms can 
      increase the drug targeting efficacy, in the meantime, reduce side 
      effects/toxicities of payloads, which are key factors for improving patient 
      compliance. In academic field, variety of smart DDSs have been abundantly 
      demonstrated for various intriguing systems, such as stimuli-responsive polymeric 
      nanoparticles, liposomes, metals/metal oxides, and exosomes. However, these 
      nanoplatforms are lack of standardized manufacturing method, toxicity assessment 
      experience, and clear relevance between the pre-clinical and clinical studies, 
      resulting in the huge difficulties to obtain regulatory and ethics approval. 
      Therefore, such relatively complex stimulus-sensitive nano-DDSs are not currently 
      approved for clinical use. In this review, we highlight the recent advances of 
      smart nanoplatforms for targeting drug delivery. Furthermore, the clinical 
      translation obstacles faced by these smart nanoplatforms have been reviewed and 
      discussed. We also present the future directions and perspectives of 
      stimuli-sensitive DDS in clinical applications.
FAU - Liu, Dong
AU  - Liu D
AD  - State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials 
      and Devices, School of Biomedical Sciences and Medical Engineering, Southeast 
      University, Nanjing, 210009, China.
FAU - Yang, Fang
AU  - Yang F
AD  - State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials 
      and Devices, School of Biomedical Sciences and Medical Engineering, Southeast 
      University, Nanjing, 210009, China.
FAU - Xiong, Fei
AU  - Xiong F
AD  - State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials 
      and Devices, School of Biomedical Sciences and Medical Engineering, Southeast 
      University, Nanjing, 210009, China.
FAU - Gu, Ning
AU  - Gu N
AD  - State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials 
      and Devices, School of Biomedical Sciences and Medical Engineering, Southeast 
      University, Nanjing, 210009, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20160607
PL  - Australia
TA  - Theranostics
JT  - Theranostics
JID - 101552395
SB  - IM
MH  - Animals
MH  - *Drug Delivery Systems
MH  - Drug Discovery/*methods/*trends
MH  - Humans
MH  - Molecular Targeted Therapy/*methods
MH  - Nanoparticles/*administration & dosage
MH  - Theranostic Nanomedicine/*methods
PMC - PMC4924501
OTO - NOTNLM
OT  - Biomaterials
OT  - Controlled release
OT  - Drug delivery system (DDS)
OT  - Nanomedicine.
OT  - Smart nanoplatform
COIS- Competing Interests: The authors have declared that no competing interest exists.
EDAT- 2016/07/05 06:00
MHDA- 2017/10/31 06:00
PMCR- 2016/01/01
CRDT- 2016/07/05 06:00
PHST- 2015/12/31 00:00 [received]
PHST- 2016/05/22 00:00 [accepted]
PHST- 2016/07/05 06:00 [entrez]
PHST- 2016/07/05 06:00 [pubmed]
PHST- 2017/10/31 06:00 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - thnov06p1306 [pii]
AID - 10.7150/thno.14858 [doi]
PST - epublish
SO  - Theranostics. 2016 Jun 7;6(9):1306-23. doi: 10.7150/thno.14858. eCollection 2016.