PMID- 27377684
OWN - NLM
STAT- MEDLINE
DCOM- 20170302
LR  - 20190320
IS  - 1878-0334 (Electronic)
IS  - 1871-4021 (Linking)
VI  - 10
IP  - 4
DP  - 2016 Oct-Dec
TI  - Association of glutathione-S-transferase with patients of type 2 diabetes 
      mellitus with and without nephropathy.
PG  - 194-197
LID - S1871-4021(16)30048-0 [pii]
LID - 10.1016/j.dsx.2016.06.006 [doi]
AB  - STATEMENTS OF THE PROBLEM: Hyperglycemia induced oxidative stress is implicated 
      as a contributor to the onset and progression of type 2 diabetes mellitus (T2DM) 
      and its complications like diabetic nephropathy (DN). Glutathione-S-transferase 
      (GST) is primarily involved in the neutralization of reactive oxygen species 
      (ROS) by enzymatic conjugation with the scavenger peptide glutathione (GSH). 
      Therefore, present study was aimed to evaluate the role of GST along with 
      oxidative stress markers and their correlation in patients with Type 2 diabetes 
      mellitus with and without nephropathy. METHODS: This study comprised of 300 
      participants divided into three groups of 100 each: healthy controls (HC), T2DM 
      without complications and DN. Plasma GST, malondialdehyde (MDA), reduced GSH 
      levels and ferric reducing ability of plasma (FRAP) were estimated 
      spectrophotometrically. RESULTS: Highest GST levels was observed in T2DM which 
      was significantly higher (p<0.05) as compared to DN and HC. However, GSH and FRAP 
      levels were found to be significantly lowest whereas MDA levels were 
      significantly highest in DN as compared to T2DM and HC. GST showed a significant 
      negative correlation with GSH, FRAP and positive correlation with MDA in both 
      patients groups. CONCLUSIONS: Highest activity of GST in T2DM might be as a 
      compensatory mechanism in response to oxidative stress. GST is found to have 
      significant negative association with decreased GSH. Altered redox milieu in DN 
      collectively conspire to increase the risk of renal damage in T2DM.
CI  - Copyright (c) 2016 Diabetes India. Published by Elsevier Ltd. All rights reserved.
FAU - Sharma, Mohini
AU  - Sharma M
AD  - Department of Biochemistry, University college of Medical Sciences (University of 
      Delhi) & Guru Teg Bahadur Hospital, Dilshad Garden, Delhi 110095, India.
FAU - Gupta, Stuti
AU  - Gupta S
AD  - Department of Biochemistry, University college of Medical Sciences (University of 
      Delhi) & Guru Teg Bahadur Hospital, Dilshad Garden, Delhi 110095, India.
FAU - Singh, Kalpana
AU  - Singh K
AD  - Department of Biochemistry, University college of Medical Sciences (University of 
      Delhi) & Guru Teg Bahadur Hospital, Dilshad Garden, Delhi 110095, India.
FAU - Mehndiratta, Mohit
AU  - Mehndiratta M
AD  - Department of Biochemistry, University college of Medical Sciences (University of 
      Delhi) & Guru Teg Bahadur Hospital, Dilshad Garden, Delhi 110095, India.
FAU - Gautam, Amar
AU  - Gautam A
AD  - Department of Medicine, University college of Medical Sciences (University of 
      Delhi) & Guru Teg Bahadur Hospital, Dilshad Garden, Delhi 110095, India.
FAU - Kalra, Om P
AU  - Kalra OP
AD  - Department of Medicine, University college of Medical Sciences (University of 
      Delhi) & Guru Teg Bahadur Hospital, Dilshad Garden, Delhi 110095, India.
FAU - Shukla, Rimi
AU  - Shukla R
AD  - Department of Biochemistry, University college of Medical Sciences (University of 
      Delhi) & Guru Teg Bahadur Hospital, Dilshad Garden, Delhi 110095, India.
FAU - Gambhir, Jasvinder K
AU  - Gambhir JK
AD  - Department of Biochemistry, University college of Medical Sciences (University of 
      Delhi) & Guru Teg Bahadur Hospital, Dilshad Garden, Delhi 110095, India. 
      Electronic address: jassigambhir@yahoo.co.in.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20160608
PL  - Netherlands
TA  - Diabetes Metab Syndr
JT  - Diabetes & metabolic syndrome
JID - 101462250
RN  - 0 (Biomarkers)
RN  - 0 (Reactive Oxygen Species)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 2.5.1.18 (Glutathione Transferase)
SB  - IM
MH  - Biomarkers/*metabolism
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*complications/enzymology
MH  - Diabetic Nephropathies/*enzymology/etiology/pathology
MH  - Female
MH  - Follow-Up Studies
MH  - Glutathione Transferase/*metabolism
MH  - Humans
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Middle Aged
MH  - Oxidative Stress
MH  - Prognosis
MH  - Reactive Oxygen Species/metabolism
OTO - NOTNLM
OT  - Diabetic nephropathy
OT  - GSH
OT  - GST
OT  - Oxidative stress markers
OT  - Type 2 diabetes mellitus
EDAT- 2016/10/23 06:00
MHDA- 2019/03/21 06:00
CRDT- 2016/07/06 06:00
PHST- 2016/03/11 00:00 [received]
PHST- 2016/06/06 00:00 [accepted]
PHST- 2016/10/23 06:00 [pubmed]
PHST- 2019/03/21 06:00 [medline]
PHST- 2016/07/06 06:00 [entrez]
AID - S1871-4021(16)30048-0 [pii]
AID - 10.1016/j.dsx.2016.06.006 [doi]
PST - ppublish
SO  - Diabetes Metab Syndr. 2016 Oct-Dec;10(4):194-197. doi: 10.1016/j.dsx.2016.06.006. 
      Epub 2016 Jun 8.