PMID- 27377942
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160706
LR  - 20220409
IS  - 2093-4777 (Print)
IS  - 2093-6931 (Electronic)
IS  - 2093-4777 (Linking)
VI  - 20
IP  - 2
DP  - 2016 Jun
TI  - Pentoxifylline Alleviates Perinatal Hypoxic-Ischemia-Induced Short-term Memory 
      Impairment by Suppressing Apoptosis in the Hippocampus of Rat Pups.
PG  - 107-13
LID - 10.5213/inj.1632532.266 [doi]
AB  - PURPOSE: Perinatal hypoxic-ischemic brain damage is a major cause of acute 
      mortality and chronic neurologic morbidity in infants and children. We 
      investigated the effects of pentoxifylline, a methylxanthine derivative and 
      type-4 phosphodiesterase inhibitor, on short-term memory and apoptotic neuronal 
      cell death in the hippocampus following perinatal hypoxic-ischemia in newborn 
      rats. METHODS: We used a step-down avoidance task to evaluate short-term memory 
      and 3'-5'-cyclic adenosine monophosphate (cAMP) assay to detect cAMP levels. We 
      evaluated apoptosis using a terminal deoxynucleotidyl transferase-mediated dUTP 
      nick end labeling (TUNEL) assay for evidence of DNA fragmentation, 
      immunohistochemistry for caspase-3 levels, and western blot for Bcl-2 and Bax. 
      RESULTS: Perinatal hypoxic-ischemic injury increased apoptotic cell death in the 
      hippocampus, resulting in impaired short-term memory with decreased cAMP levels. 
      Pentoxifylline treatment improved short-term memory by suppressing apoptotic cell 
      death in the hippocampus with elevated cAMP levels. CONCLUSIONS: Pentoxifylline 
      ameliorated perinatal hypoxic-ischemia in rat pups. This alleviating effect could 
      be ascribed to the inhibition apoptosis due to increased cAMP production by 
      pentoxifylline.
FAU - Park, Je Hoon
AU  - Park JH
AUID- ORCID: 0000-0002-6930-3793
AD  - Department of Surgery, International St. Mary's Hospital, College of Medicine, 
      Catholic Kwandong University, Incheon, Korea.
FAU - Kim, Sung Eun
AU  - Kim SE
AUID- ORCID: 0000-0003-3742-0271
AD  - Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 
      Korea.
FAU - Jin, Jun Jang
AU  - Jin JJ
AUID- ORCID: 0000-0001-5594-5915
AD  - Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 
      Korea.
FAU - Choi, Han Sung
AU  - Choi HS
AUID- ORCID: 0000-0001-7477-5405
AD  - Department of Emergency Medicine, College of Medicine, Kyung Hee University, 
      Seoul, Korea.
FAU - Kim, Chang Ju
AU  - Kim CJ
AUID- ORCID: 0000-0003-4749-5795
AD  - Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 
      Korea.
FAU - Ko, Il Gyu
AU  - Ko IG
AUID- ORCID: 0000-0003-2696-6869
AD  - Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 
      Korea.
LA  - eng
PT  - Journal Article
DEP - 20160624
PL  - Korea (South)
TA  - Int Neurourol J
JT  - International neurourology journal
JID - 101534513
PMC - PMC4932643
OTO - NOTNLM
OT  - Apoptosis
OT  - Cyclic AMP
OT  - Hypoxia-Ischemia
OT  - Memory
OT  - Pentoxifylline
OT  - Phosphodiesterase-4 Inhibitors
COIS- Conflict of Interest No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2016/07/06 06:00
MHDA- 2016/07/06 06:01
PMCR- 2016/06/01
CRDT- 2016/07/06 06:00
PHST- 2016/02/15 00:00 [received]
PHST- 2016/03/17 00:00 [accepted]
PHST- 2016/07/06 06:00 [entrez]
PHST- 2016/07/06 06:00 [pubmed]
PHST- 2016/07/06 06:01 [medline]
PHST- 2016/06/01 00:00 [pmc-release]
AID - inj-1632532-266 [pii]
AID - 10.5213/inj.1632532.266 [doi]
PST - ppublish
SO  - Int Neurourol J. 2016 Jun;20(2):107-13. doi: 10.5213/inj.1632532.266. Epub 2016 
      Jun 24.