PMID- 27378417
OWN - NLM
STAT- MEDLINE
DCOM- 20180525
LR  - 20181113
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 6
DP  - 2016 Jul 5
TI  - Multivariate Neural Representations of Value during Reward Anticipation and 
      Consummation in the Human Orbitofrontal Cortex.
PG  - 29079
LID - 10.1038/srep29079 [doi]
LID - 29079
AB  - The role of the orbitofrontal cortex (OFC) in value processing is a focus of 
      research. Conventional imaging analysis, where smoothing and averaging are 
      employed, may not be sufficiently sensitive in studying the OFC, which has 
      heterogeneous anatomical structures and functions. In this study, we employed 
      representational similarity analysis (RSA) to reveal the multi-voxel fMRI 
      patterns in the OFC associated with value processing during the anticipatory and 
      the consummatory phases. We found that multi-voxel activation patterns in the OFC 
      encoded magnitude and partial valence information (win vs. loss) but not outcome 
      (favourable vs. unfavourable) during reward consummation. Furthermore, the 
      lateral OFC rather than the medial OFC encoded loss information. Also, we found 
      that OFC encoded values in a similar way to the ventral striatum (VS) or the 
      anterior insula (AI) during reward anticipation regardless of motivated response 
      and to the medial prefrontal cortex (MPFC) and the VS in reward consummation. In 
      contrast, univariate analysis did not show changes of activation in the OFC. 
      These findings suggest an important role of the OFC in value processing during 
      reward anticipation and consummation.
FAU - Yan, Chao
AU  - Yan C
AD  - Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of 
      Mental Health, Institute of Psychology, Chinese Academy of Sciences, Room 606, 
      South Building, 16 Lincui Road, Beijing, Beijing, 100101 China.
AD  - Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key 
      Laboratory of Brain Functional Genomics (MOE &STCSM), East China Normal 
      University, Room 213, Junxiu Building, 3663 North Zhongshan Road, Shanghai, 
      200062 China.
FAU - Su, Li
AU  - Su L
AD  - Department of Psychiatry, Cambridge Biomedical Campus, University of Cambridge, 
      Cambridge, CB2 0SP UK.
FAU - Wang, Yi
AU  - Wang Y
AD  - Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of 
      Mental Health, Institute of Psychology, Chinese Academy of Sciences, Room 606, 
      South Building, 16 Lincui Road, Beijing, Beijing, 100101 China.
FAU - Xu, Ting
AU  - Xu T
AD  - Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of 
      Mental Health, Institute of Psychology, Chinese Academy of Sciences, Room 606, 
      South Building, 16 Lincui Road, Beijing, Beijing, 100101 China.
FAU - Yin, Da-Zhi
AU  - Yin DZ
AD  - Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese 
      Academy of Sciences, 320 Yue Yang Road, Shanghai, 200031 China.
FAU - Fan, Ming-Xia
AU  - Fan MX
AD  - Shanghai Key Laboratory of MRI, East China Normal University, 3663 North 
      Zhongshan Road, Shanghai, 200062 China.
FAU - Deng, Ci-Ping
AU  - Deng CP
AD  - Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key 
      Laboratory of Brain Functional Genomics (MOE &STCSM), East China Normal 
      University, Room 213, Junxiu Building, 3663 North Zhongshan Road, Shanghai, 
      200062 China.
FAU - Hu, Yang
AU  - Hu Y
AD  - Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key 
      Laboratory of Brain Functional Genomics (MOE &STCSM), East China Normal 
      University, Room 213, Junxiu Building, 3663 North Zhongshan Road, Shanghai, 
      200062 China.
FAU - Wang, Zhao-Xin
AU  - Wang ZX
AD  - Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key 
      Laboratory of Brain Functional Genomics (MOE &STCSM), East China Normal 
      University, Room 213, Junxiu Building, 3663 North Zhongshan Road, Shanghai, 
      200062 China.
FAU - Cheung, Eric F C
AU  - Cheung EF
AD  - Department of General Adult Psychiatry, Castle Peak Hospital, 15 Tsing Chung Koon 
      Road, Tuen Mun, N.T. Hong Kong Special Administrative Region, China.
FAU - Lim, Kelvin O
AU  - Lim KO
AD  - Department of Psychiatry, University of Minnesota, F282/2A West 2450 Riverside 
      Avenue, Minneapolis, MN 55454 USA.
FAU - Chan, Raymond C K
AU  - Chan RC
AD  - Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of 
      Mental Health, Institute of Psychology, Chinese Academy of Sciences, Room 606, 
      South Building, 16 Lincui Road, Beijing, Beijing, 100101 China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160705
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Adult
MH  - Anticipation, Psychological/*physiology
MH  - Brain Mapping
MH  - Female
MH  - Frontal Lobe/diagnostic imaging/*physiology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Memory/*physiology
MH  - Motivation/physiology
MH  - Prefrontal Cortex/diagnostic imaging/*physiology
MH  - Reward
MH  - Young Adult
PMC - PMC4932626
EDAT- 2016/07/06 06:00
MHDA- 2018/05/26 06:00
PMCR- 2016/07/05
CRDT- 2016/07/06 06:00
PHST- 2015/10/02 00:00 [received]
PHST- 2016/06/10 00:00 [accepted]
PHST- 2016/07/06 06:00 [entrez]
PHST- 2016/07/06 06:00 [pubmed]
PHST- 2018/05/26 06:00 [medline]
PHST- 2016/07/05 00:00 [pmc-release]
AID - srep29079 [pii]
AID - 10.1038/srep29079 [doi]
PST - epublish
SO  - Sci Rep. 2016 Jul 5;6:29079. doi: 10.1038/srep29079.