PMID- 27378860
OWN - NLM
STAT- MEDLINE
DCOM- 20171023
LR  - 20191210
IS  - 1662-5110 (Electronic)
IS  - 1662-5110 (Linking)
VI  - 10
DP  - 2016
TI  - Distinct Spatiotemporal Activation Patterns of the Perirhinal-Entorhinal Network 
      in Response to Cortical and Amygdala Input.
PG  - 44
LID - 10.3389/fncir.2016.00044 [doi]
LID - 44
AB  - The perirhinal (PER) and entorhinal cortex (EC) receive input from the agranular 
      insular cortex (AiP) and the subcortical lateral amygdala (LA) and the main 
      output area is the hippocampus. Information transfer through the PER/EC network 
      however, is not always guaranteed. It is hypothesized that this network actively 
      regulates the (sub)cortical activity transfer to the hippocampal network and that 
      the inhibitory system is involved in this function. This study determined the 
      recruitment by the AiP and LA afferents in PER/EC network with the use of voltage 
      sensitive dye (VSD) imaging in horizontal mouse brain slices. Electrical 
      stimulation (500 muA) of the AiP induced activity that gradually propagated 
      predominantly in the rostro-caudal direction: from the PER to the lateral EC 
      (LEC). In the presence of 1 muM of the competitive gamma-aminobutyric acid (GABAA) 
      receptor antagonist bicuculline, AiP stimulation recruited the medial EC (MEC) as 
      well. In contrast, LA stimulation (500 muA) only induced activity in the deep 
      layers of the PER. In the presence of bicuculline, the initial population 
      activity in the PER propagated further towards the superficial layers and the EC 
      after a delay. The latency of evoked responses decreased with increasing stimulus 
      intensities (50-500 muA) for both the AiP and LA stimuli. The stimulation 
      threshold for evoking responses in the PER/EC network was higher for the LA than 
      for the AiP. This study showed that the extent of the PER/EC network activation 
      depends on release of inhibition. When GABAA dependent inhibition is reduced, 
      both the AiP and the LA activate spatially overlapping regions, although in a 
      distinct spatiotemporal fashion. It is therefore hypothesized that the inhibitory 
      network regulates excitatory activity from both cortical and subcortical areas 
      that has to be transmitted through the PER/EC network.
FAU - Willems, Janske G P
AU  - Willems JG
AD  - Center for NeuroScience, Swammerdam Institute for Life Sciences, University of 
      Amsterdam Amsterdam, Netherlands.
FAU - Wadman, Wytse J
AU  - Wadman WJ
AD  - Center for NeuroScience, Swammerdam Institute for Life Sciences, University of 
      Amsterdam Amsterdam, Netherlands.
FAU - Cappaert, Natalie L M
AU  - Cappaert NL
AD  - Center for NeuroScience, Swammerdam Institute for Life Sciences, University of 
      Amsterdam Amsterdam, Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20160614
PL  - Switzerland
TA  - Front Neural Circuits
JT  - Frontiers in neural circuits
JID - 101477940
RN  - 0 (GABA-A Receptor Antagonists)
RN  - Y37615DVKC (Bicuculline)
SB  - IM
MH  - Amygdala/drug effects/*physiology
MH  - Animals
MH  - Bicuculline/pharmacology
MH  - Cerebral Cortex/drug effects/*physiology
MH  - Electric Stimulation
MH  - Entorhinal Cortex/drug effects/*physiology
MH  - Female
MH  - GABA-A Receptor Antagonists/pharmacology
MH  - Hippocampus/*physiology
MH  - *Inhibition, Psychological
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Nerve Net/drug effects/*physiology
MH  - Perirhinal Cortex/drug effects/*physiology
MH  - Voltage-Sensitive Dye Imaging
PMC - PMC4906015
OTO - NOTNLM
OT  - acute slices
OT  - inhibitory control
OT  - mouse
OT  - network recruitment
OT  - parahippocampal region
OT  - voltage-sensitive dye imaging
EDAT- 2016/07/06 06:00
MHDA- 2017/10/24 06:00
PMCR- 2016/01/01
CRDT- 2016/07/06 06:00
PHST- 2016/02/04 00:00 [received]
PHST- 2016/05/30 00:00 [accepted]
PHST- 2016/07/06 06:00 [entrez]
PHST- 2016/07/06 06:00 [pubmed]
PHST- 2017/10/24 06:00 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - 10.3389/fncir.2016.00044 [doi]
PST - epublish
SO  - Front Neural Circuits. 2016 Jun 14;10:44. doi: 10.3389/fncir.2016.00044. 
      eCollection 2016.