PMID- 27379793
OWN - NLM
STAT- MEDLINE
DCOM- 20170214
LR  - 20181113
IS  - 1439-6327 (Electronic)
IS  - 1439-6319 (Linking)
VI  - 116
IP  - 9
DP  - 2016 Sep
TI  - Seven days of high carbohydrate ingestion does not attenuate post-exercise IL-6 
      and hepcidin levels.
PG  - 1715-24
LID - 10.1007/s00421-016-3426-7 [doi]
AB  - PURPOSE: This investigation examined if a high carbohydrate (CHO) diet, 
      maintained across a seven-day training period, could attenuate post-exercise 
      interleukin-6 (IL-6) and serum hepcidin levels. METHODS: Twelve endurance-trained 
      male athletes completed two seven-day running training blocks whilst consuming 
      either a high (8 g kg(-1)) versus a low (3 g kg(-1)) CHO isoenergetic diet. Each 
      training block consisted of five running sessions performed on days 1, 2, 4, 5, 
      and 7, with the intensity and duration of each session matched between training 
      weeks. Serum levels of Interleukin-6 (IL-6) and hepcidin were measured pre- and 
      either immediately (IL-6) or 3-h (hepcidin) post-exercise on days 1 and 7 of each 
      training week. RESULTS: During each training week, the immediate post-exercise 
      IL-6 and 3-h post-exercise serum hepcidin levels were significantly elevated 
      (both p = 0.001) from pre-exercise on days 1 and 7. These increases were not 
      different between trials. CONCLUSIONS: These results suggest that the ingestion 
      of a high (compared to low) CHO diet over a seven-day training period is 
      ineffective in attenuating post-exercise IL-6 and hepcidin responses. Such 
      results may be due to the modest training load, the increased protein intake in 
      the low-CHO trial, and a 48 h recovery period prior to sample collection on day 
      7, allowing a full recovery of muscle glycogen status between exercise sessions.
FAU - Badenhorst, Claire E
AU  - Badenhorst CE
AD  - School of Sport Science, The University of Western Australia Crawley, Exercise 
      and Health M408, 35 Stirling Hwy, Crawley, 6009, Western Australia. 
      claire.badenhorst@research.uwa.edu.au.
FAU - Dawson, Brian
AU  - Dawson B
AD  - School of Sport Science, The University of Western Australia Crawley, Exercise 
      and Health M408, 35 Stirling Hwy, Crawley, 6009, Western Australia.
FAU - Cox, Gregory R
AU  - Cox GR
AD  - Sports Nutrition, Australian Institute of Sport, Gold Coast, QLD, Australia.
FAU - Sim, Marc
AU  - Sim M
AD  - Western Australian Institute of Sport, Mt Claremont, Western Australia.
AD  - School of Human Movement and Sport Science, Federation University, Mt Helen, VIC, 
      Australia.
FAU - Laarakkers, Coby M
AU  - Laarakkers CM
AD  - Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, 
      The Netherlands.
AD  - Hepcidinanalysis.com, Nijmegen, The Netherlands.
FAU - Swinkels, Dorine W
AU  - Swinkels DW
AD  - Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, 
      The Netherlands.
AD  - Hepcidinanalysis.com, Nijmegen, The Netherlands.
FAU - Peeling, Peter
AU  - Peeling P
AD  - School of Sport Science, The University of Western Australia Crawley, Exercise 
      and Health M408, 35 Stirling Hwy, Crawley, 6009, Western Australia.
AD  - Western Australian Institute of Sport, Mt Claremont, Western Australia.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20160705
PL  - Germany
TA  - Eur J Appl Physiol
JT  - European journal of applied physiology
JID - 100954790
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Hepcidins)
RN  - 0 (IL6 protein, human)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukin-6)
SB  - IM
MH  - Adult
MH  - Dietary Carbohydrates/*administration & dosage/*immunology
MH  - Exercise/*physiology
MH  - Hepcidins/*blood/immunology
MH  - Humans
MH  - Inflammation Mediators/*blood/immunology
MH  - Interleukin-6/*blood/immunology
MH  - Male
OTO - NOTNLM
OT  - Endurance training
OT  - Inflammation
OT  - Iron metabolism
OT  - Nutrition
EDAT- 2016/07/06 06:00
MHDA- 2017/02/15 06:00
CRDT- 2016/07/06 06:00
PHST- 2016/06/06 00:00 [received]
PHST- 2016/07/01 00:00 [accepted]
PHST- 2016/07/06 06:00 [entrez]
PHST- 2016/07/06 06:00 [pubmed]
PHST- 2017/02/15 06:00 [medline]
AID - 10.1007/s00421-016-3426-7 [pii]
AID - 10.1007/s00421-016-3426-7 [doi]
PST - ppublish
SO  - Eur J Appl Physiol. 2016 Sep;116(9):1715-24. doi: 10.1007/s00421-016-3426-7. Epub 
      2016 Jul 5.