PMID- 27380463
OWN - NLM
STAT- MEDLINE
DCOM- 20180827
LR  - 20180827
IS  - 1744-5078 (Electronic)
IS  - 0927-3948 (Linking)
VI  - 26
IP  - 1
DP  - 2018
TI  - Genotype-Phenotype Association Study Reveals CFI-Rs13104777 to be a Protective 
      Genetic Marker Against Acute Anterior Uveitis.
PG  - 51-56
LID - 10.1080/09273948.2016.1178305 [doi]
AB  - PURPOSE: To investigate the roles of CFI, genotype-phenotype associations were 
      identified in AAU. METHODS: A case-control study was conducted in a total of 575 
      subjects consisting of 279 AAU patients and 296 healthy controls. Genotypic 
      analyses were performed using Sequenom MassARRAY technology. Analyses were 
      stratified to a series of clinical ophthalmic confounding factors. RESULTS: A 
      lower frequency of the CFI-rs13104777 C allele was found in the AAU cohort 
      compared with the controls, and, thus, was significantly associated with AAU 
      pathogenesis (p = 0.041, OR = 0.712, 95% CI: 0.513-0.987). Stratified analysis 
      also demonstrated the associations may differ depending on the HLA-B27 status and 
      laterality status. CONCLUSIONS: This study has revealed a significant genetic 
      role for CFI-rs13104777 in AAU. This influence may be dependent on human 
      leukocyte antigen (HLA)-B27 and disease laterality. Overall, the results provide 
      evidence for a pathogenic role for CFI in AAU and expand our knowledge on the 
      genetic basis of AAU.
FAU - Huang, Xiu-Feng
AU  - Huang XF
AD  - a The Eye Hospital of Wenzhou Medical University, the State Key Laboratory 
      Cultivation Base and Key Laboratory of Vision Science, Ministry of Health , 
      Wenzhou , China.
FAU - Lin, Dan
AU  - Lin D
AD  - a The Eye Hospital of Wenzhou Medical University, the State Key Laboratory 
      Cultivation Base and Key Laboratory of Vision Science, Ministry of Health , 
      Wenzhou , China.
FAU - Lin, Keng-Hung
AU  - Lin KH
AD  - b Department of Ophthalmology , Taichung Veterans General Hospital, National 
      Yang-Ming University , Taichung , Taiwan , China.
FAU - Lee, Shi-Huang
AU  - Lee SH
AD  - b Department of Ophthalmology , Taichung Veterans General Hospital, National 
      Yang-Ming University , Taichung , Taiwan , China.
FAU - Xia, Xiaoru
AU  - Xia X
AD  - c Department of Rheumatology , The First Affiliated Hospital of Wenzhou Medical 
      University , Wenzhou , China.
FAU - Yang, Yi-Mai
AU  - Yang YM
AD  - d Wenzhou People's Hospital, Wenzhou Physical Examination Center.
FAU - Zhu, Xue-Fei
AU  - Zhu XF
AD  - e Department of Ophthalmology , The First Affiliated Hospital of Soochow 
      University.
FAU - Wang, Yu-Lin
AU  - Wang YL
AD  - f The department of ophthalmology , The First Affiliated Hospital of Nanchang 
      University , Nanchang , China.
FAU - Dai, Ma-Li
AU  - Dai ML
AD  - a The Eye Hospital of Wenzhou Medical University, the State Key Laboratory 
      Cultivation Base and Key Laboratory of Vision Science, Ministry of Health , 
      Wenzhou , China.
FAU - Wang, Qing-Feng
AU  - Wang QF
AD  - a The Eye Hospital of Wenzhou Medical University, the State Key Laboratory 
      Cultivation Base and Key Laboratory of Vision Science, Ministry of Health , 
      Wenzhou , China.
FAU - Jin, Zi-Bing
AU  - Jin ZB
AD  - a The Eye Hospital of Wenzhou Medical University, the State Key Laboratory 
      Cultivation Base and Key Laboratory of Vision Science, Ministry of Health , 
      Wenzhou , China.
FAU - Wang, Yuqin
AU  - Wang Y
AD  - a The Eye Hospital of Wenzhou Medical University, the State Key Laboratory 
      Cultivation Base and Key Laboratory of Vision Science, Ministry of Health , 
      Wenzhou , China.
LA  - eng
PT  - Journal Article
DEP - 20160705
PL  - England
TA  - Ocul Immunol Inflamm
JT  - Ocular immunology and inflammation
JID - 9312169
RN  - 0 (Genetic Markers)
RN  - 0 (HLA-B27 Antigen)
RN  - EC 3.4.21.45 (CFI protein, human)
RN  - EC 3.4.21.45 (Complement Factor I)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Case-Control Studies
MH  - Complement Factor I/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Markers/*genetics
MH  - Genotyping Techniques
MH  - HLA-B27 Antigen/genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Single Nucleotide
MH  - Uveitis, Anterior/*genetics
OTO - NOTNLM
OT  - Acute anterior uveitis
OT  - CFI
OT  - association analysis
OT  - genotype-phenotype association
OT  - polymorphisms
EDAT- 2016/07/06 06:00
MHDA- 2018/08/28 06:00
CRDT- 2016/07/06 06:00
PHST- 2016/07/06 06:00 [pubmed]
PHST- 2018/08/28 06:00 [medline]
PHST- 2016/07/06 06:00 [entrez]
AID - 10.1080/09273948.2016.1178305 [doi]
PST - ppublish
SO  - Ocul Immunol Inflamm. 2018;26(1):51-56. doi: 10.1080/09273948.2016.1178305. Epub 
      2016 Jul 5.