PMID- 27380974
OWN - NLM
STAT- MEDLINE
DCOM- 20170809
LR  - 20181113
IS  - 1998-3689 (Electronic)
IS  - 0301-4738 (Print)
IS  - 0301-4738 (Linking)
VI  - 64
IP  - 5
DP  - 2016 May
TI  - Lamina depth and thickness correlate with glaucoma severity.
PG  - 358-63
LID - 10.4103/0301-4738.185594 [doi]
AB  - PURPOSE: To evaluate the correlation between lamina cribrosa (LC) morphology and 
      glaucoma severity in patients with primary forms of open-angle glaucoma (OAG) 
      using enhanced depth imaging spectral-domain optical coherence tomography 
      (SD-OCT) and Humphrey visual field test (HVF). SUBJECTS AND METHODS: Patients 
      with OAG (n = 166), divided into normal-tension glaucoma (NTG) and high-tension 
      glaucoma (HTG) groups (n = 66 and n = 100), were imaged using SD-OCT to obtain 
      horizontal B-scan images of the optic nerve head (ONH). Laminar depth (LD) and 
      laminar thickness (LT) were measured at the center of ONH. RESULTS: The mean 
      (+/-standard deviation) values of LD, LT, and visual field mean deviation (MD) were 
      555.4 +/- 142.3 mum, 179.9 +/- 49.7 mum, and - 5.7 +/- 6.4 dB, respectively. In the 
      multivariate linear regression analysis, LD, LT, and intraocular pressure (IOP) 
      were significantly correlated with MD (P = 0.007, P = 0.037, and P = 0.004, 
      respectively). In the subgroup analyses, only LD was associated with MD in the 
      NTG group (n = 66), whereas LT and IOP were correlated with MD in the HTG group 
      (n = 100). Neither axial length nor central corneal thickness was associated with 
      LD or LT. CONCLUSIONS: Glaucoma severity, as measured by HVF MD, shows 
      significant correlations with LD and LT, with greater severity associated with 
      increasing LD and decreasing LT. Normal- and high-tension OAG patients have 
      different associations with LD and LT, which implies that the pathogenesis of 
      these two entities might be different.
FAU - Kim, Martha
AU  - Kim M
AD  - Department of Ophthalmology, Dongguk University Ilsan Hospital, Goyang, Korea; 
      Department of Ophthalmology, University of Washington, Seattle, WA, USA, .
FAU - Bojikian, Karine D
AU  - Bojikian KD
AD  - Department of Ophthalmology, University of Washington, Seattle, WA, USA.
FAU - Slabaugh, Mark A
AU  - Slabaugh MA
AD  - Department of Ophthalmology, University of Washington, Seattle, WA, USA.
FAU - Ding, Leona
AU  - Ding L
AD  - Department of Ophthalmology, University of Washington, Seattle, WA, USA.
FAU - Chen, Philip P
AU  - Chen PP
AD  - Department of Ophthalmology, University of Washington, Seattle, WA, USA.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Ophthalmol
JT  - Indian journal of ophthalmology
JID - 0405376
SB  - IM
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Glaucoma/*diagnosis/physiopathology
MH  - Humans
MH  - *Intraocular Pressure
MH  - Male
MH  - Optic Disk/*pathology
MH  - Prospective Studies
MH  - Severity of Illness Index
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Field Tests
MH  - *Visual Fields
PMC - PMC4966372
EDAT- 2016/07/07 06:00
MHDA- 2017/08/10 06:00
PMCR- 2016/05/01
CRDT- 2016/07/07 06:00
PHST- 2016/07/07 06:00 [entrez]
PHST- 2016/07/07 06:00 [pubmed]
PHST- 2017/08/10 06:00 [medline]
PHST- 2016/05/01 00:00 [pmc-release]
AID - IndianJOphthalmol_2016_64_5_358_185594 [pii]
AID - IJO-64-358 [pii]
AID - 10.4103/0301-4738.185594 [doi]
PST - ppublish
SO  - Indian J Ophthalmol. 2016 May;64(5):358-63. doi: 10.4103/0301-4738.185594.