PMID- 27381585
OWN - NLM
STAT- MEDLINE
DCOM- 20170313
LR  - 20220410
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 92
DP  - 2016 Nov
TI  - Development and evaluation of PLGA polymer based nanoparticles of quercetin.
PG  - 213-219
LID - S0141-8130(16)30702-4 [pii]
LID - 10.1016/j.ijbiomac.2016.07.002 [doi]
AB  - Quercetin is the most abundant antioxidant found in the human diet. Low aqueous 
      solubility of quercetin limits its bioavailability and hence therapeutic effects. 
      Therefore, the aim of the present study was to develop a poly lactide-co-glycolic 
      acid (PLGA) polymer based nanoparticles of quercetin with a view to improve its 
      aqueous solubility and examine the effect on its antioxidant and diuretic 
      properties. Nanoparticles of quercetin were developed by single emulsion-solvent 
      evaporation technique and evaluated in vitro for differential scanning 
      calorimetry (DSC), Fourier transforms infra-red (FTIR) spectroscopy, particle 
      size, polydispersity index and drug entrapment efficiency. Among the five 
      different formulations (F1, F2, F3, F4 and F5), F2 and F3 were optimized with an 
      average particle size of 189nm and 186nm and high entrapment values of 86.48%, 
      83.71%, respectively. SEM images of confirmed that prepared nanoparticles were 
      spherical in shape with a smooth surface. In vitro release and anti-oxidant 
      activity confirmed significant results. Furthermore, its in vivo diuretic 
      activity was much better as compared to pure quercetin. The overall results 
      suggest that PLGA polymer based nanoparticle could be a potential option for 
      quercetin delivery.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Anwer, Md Khalid
AU  - Anwer MK
AD  - Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz 
      University, Al-kharj 11942, Saudi Arabia. Electronic address: 
      mkanwer2002@yahoo.co.in.
FAU - Al-Mansoor, Mohammed A
AU  - Al-Mansoor MA
AD  - Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz 
      University, Al-kharj 11942, Saudi Arabia.
FAU - Jamil, Shahid
AU  - Jamil S
AD  - Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz 
      University, Al-kharj 11942, Saudi Arabia.
FAU - Al-Shdefat, Ramadan
AU  - Al-Shdefat R
AD  - Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz 
      University, Al-kharj 11942, Saudi Arabia.
FAU - Ansari, Mohammad Nazam
AU  - Ansari MN
AD  - Department of Pharmacology, College of Pharmacy, Prince Sattam Bin Abdulaziz 
      University, Al-kharj 11942, Saudi Arabia.
FAU - Shakeel, Faiyaz
AU  - Shakeel F
AD  - Center of Excellence in Biotechnology Research (CEBR), King Saud University, P.O. 
      Box 2460, Riyadh 11451, Saudi Arabia.
LA  - eng
PT  - Journal Article
DEP - 20160702
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 0 (Antioxidants)
RN  - 0 (Biphenyl Compounds)
RN  - 0 (Carbonic Anhydrase Inhibitors)
RN  - 0 (Electrolytes)
RN  - 0 (Picrates)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 9IKM0I5T1E (Quercetin)
RN  - DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Antioxidants/pharmacology
MH  - Biphenyl Compounds/chemistry
MH  - Calorimetry, Differential Scanning
MH  - Carbonic Anhydrase Inhibitors/pharmacology
MH  - Drug Liberation
MH  - Electrolytes/chemistry
MH  - Lactic Acid/*chemistry
MH  - Male
MH  - Nanoparticles/*chemistry/ultrastructure
MH  - Particle Size
MH  - Picrates/chemistry
MH  - Polyglycolic Acid/*chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Quercetin/administration & dosage/*pharmacology
MH  - Rats, Wistar
MH  - Reference Standards
MH  - Spectroscopy, Fourier Transform Infrared
OTO - NOTNLM
OT  - Diuretic activity
OT  - PLGA nanoparticle
OT  - Quercetin
EDAT- 2016/07/07 06:00
MHDA- 2017/03/14 06:00
CRDT- 2016/07/07 06:00
PHST- 2016/06/09 00:00 [received]
PHST- 2016/06/30 00:00 [revised]
PHST- 2016/07/01 00:00 [accepted]
PHST- 2016/07/07 06:00 [pubmed]
PHST- 2017/03/14 06:00 [medline]
PHST- 2016/07/07 06:00 [entrez]
AID - S0141-8130(16)30702-4 [pii]
AID - 10.1016/j.ijbiomac.2016.07.002 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2016 Nov;92:213-219. doi: 10.1016/j.ijbiomac.2016.07.002. 
      Epub 2016 Jul 2.