PMID- 27381990
OWN - NLM
STAT- MEDLINE
DCOM- 20170828
LR  - 20220408
IS  - 1590-3729 (Electronic)
IS  - 0939-4753 (Linking)
VI  - 26
IP  - 9
DP  - 2016 Sep
TI  - Disorders of glucose metabolism in Prader-Willi syndrome: Results of a 
      multicenter Italian cohort study.
PG  - 842-7
LID - S0939-4753(15)30206-4 [pii]
LID - 10.1016/j.numecd.2016.05.010 [doi]
AB  - BACKGROUND AND AIMS: Prader-Willi syndrome (PWS) is characterized by a high 
      incidence of altered glucose metabolism (AGM). However, epidemiological data on 
      impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and type 2 
      diabetes mellitus (T2DM) are still discordant. METHODS AND RESULTS: We performed 
      a multicenter study based on 274 PWS patients [144 females, aged 20.3 +/- 10.4 yrs 
      (range: 8.1-50.1 years)] evaluating the prevalence for AGM in the entire group, 
      and according to age (children <10 yrs; adolescents 10-18 yrs, and adults 
      >18 yrs), Body Mass Index (BMI = kg/m(2)), gender, genotypes (deletion or 
      uniparental disomy for chromosome 15), and GH therapy (GHT) (untreated, 
      previously or currently treated). Altogether, AGM was detected in 67 (24.4%) of 
      patients (0.7% IFG, 10.2% IGT, 13.5% T2DM). The prevalence of AGM was correlated 
      to age (p = 0.001), BMI (p = 0.001) and HOMA-IR (p = 0.001). However, gender, 
      genotype, and GHT did not influence AGM development in univariate analysis. These 
      data were confirmed as positive predictors when inserted in a multivariate 
      analysis model. CONCLUSION: This study is the first report on the prevalence of 
      AGM in a large population of PWS. Overall, PWS subjects show a high prevalence of 
      AGM that appears more common in obese and adult subjects. Our data confirm the 
      main role of obesity on the individual metabolic risk clustering in PWS, and thus 
      reinforce the concept that improvement in weight control remains the most 
      important goal of any PWS treatment program.
CI  - Copyright (c) 2016 The Italian Society of Diabetology, the Italian Society for the 
      Study of Atherosclerosis, the Italian Society of Human Nutrition, and the 
      Department of Clinical Medicine and Surgery, Federico II University. Published by 
      Elsevier B.V. All rights reserved.
FAU - Fintini, D
AU  - Fintini D
AD  - Autoimmune Endocrine Diseases Unit, Bambino Gesu Children's Hospital, Research 
      Institute, Rome, Italy. Electronic address: dfintini@hotmail.com.
FAU - Grugni, G
AU  - Grugni G
AD  - Division of Auxology, Italian Auxological Institute, Research Institute, 
      Piancavallo, Verbania, Italy.
FAU - Bocchini, S
AU  - Bocchini S
AD  - Autoimmune Endocrine Diseases Unit, Bambino Gesu Children's Hospital, Research 
      Institute, Rome, Italy.
FAU - Brufani, C
AU  - Brufani C
AD  - Autoimmune Endocrine Diseases Unit, Bambino Gesu Children's Hospital, Research 
      Institute, Rome, Italy.
FAU - Di Candia, S
AU  - Di Candia S
AD  - Pediatric Department, S. Raffaele Hospital, Milan, Italy.
FAU - Corrias, A
AU  - Corrias A
AD  - Pediatric Endocrinology, Regina Margherita Hospital, Turin, Italy.
FAU - Delvecchio, M
AU  - Delvecchio M
AD  - Department of Pediatric Science and Surgery, Pediatric Hospital Giovanni XXIII, 
      Bari, Italy.
FAU - Salvatoni, A
AU  - Salvatoni A
AD  - Pediatric Unit, Insubria University, Varese, Italy.
FAU - Ragusa, L
AU  - Ragusa L
AD  - Pediatric Unit, Oasi Maria SS, Research Institute, Troina, Enna, Italy.
FAU - Greggio, N
AU  - Greggio N
AD  - Pediatric Department, University of Padua, Italy.
FAU - Franzese, A
AU  - Franzese A
AD  - Department of Translational Sciences, University Federico II, Naples, Italy.
FAU - Scarano, E
AU  - Scarano E
AD  - Pediatric Endocrinology and Rare Diseases Unit, University of Bologna, Italy.
FAU - Trifiro, G
AU  - Trifiro G
AD  - Pediatric Unit, Salvini Hospital, Rho, Milan, Italy.
FAU - Mazzanti, L
AU  - Mazzanti L
AD  - Pediatric Endocrinology and Rare Diseases Unit, University of Bologna, Italy.
FAU - Chiumello, G
AU  - Chiumello G
AD  - Pediatric Department, S. Raffaele Hospital, Milan, Italy.
FAU - Cappa, M
AU  - Cappa M
AD  - Endocrinology and Diabetology Unit, Bambino Gesu Children's Hospital, Research 
      Institute, Rome, Italy.
FAU - Crino, A
AU  - Crino A
AD  - Autoimmune Endocrine Diseases Unit, Bambino Gesu Children's Hospital, Research 
      Institute, Rome, Italy. Electronic address: antonino.crino@opbg.net.
CN  - Genetic Obesity Study Group of the Italian Society of Pediatric Endocrinology and 
      Diabetology (ISPED)
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20160603
PL  - Netherlands
TA  - Nutr Metab Cardiovasc Dis
JT  - Nutrition, metabolism, and cardiovascular diseases : NMCD
JID - 9111474
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 12629-01-5 (Human Growth Hormone)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Distribution
MH  - Biomarkers/blood
MH  - Blood Glucose/*metabolism
MH  - Chi-Square Distribution
MH  - Child
MH  - Female
MH  - Glucose Metabolism Disorders/blood/diagnosis/*epidemiology
MH  - Human Growth Hormone/therapeutic use
MH  - Humans
MH  - Insulin Resistance
MH  - Italy/epidemiology
MH  - Linear Models
MH  - Male
MH  - Metabolic Syndrome/epidemiology
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Obesity/epidemiology
MH  - Prader-Willi Syndrome/blood/diagnosis/drug therapy/*epidemiology
MH  - Prevalence
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Young Adult
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - GH therapy
OT  - Obesity
OT  - Prader-Willi syndrome
EDAT- 2016/07/07 06:00
MHDA- 2017/08/29 06:00
CRDT- 2016/07/07 06:00
PHST- 2015/09/11 00:00 [received]
PHST- 2016/05/17 00:00 [revised]
PHST- 2016/05/23 00:00 [accepted]
PHST- 2016/07/07 06:00 [entrez]
PHST- 2016/07/07 06:00 [pubmed]
PHST- 2017/08/29 06:00 [medline]
AID - S0939-4753(15)30206-4 [pii]
AID - 10.1016/j.numecd.2016.05.010 [doi]
PST - ppublish
SO  - Nutr Metab Cardiovasc Dis. 2016 Sep;26(9):842-7. doi: 
      10.1016/j.numecd.2016.05.010. Epub 2016 Jun 3.