PMID- 27382204
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160706
LR  - 20231105
IS  - 0970-1915 (Print)
IS  - 0974-0422 (Electronic)
IS  - 0970-1915 (Linking)
VI  - 31
IP  - 3
DP  - 2016 Jul
TI  - Altered Erythrocyte Glycolytic Enzyme Activities in Type-II Diabetes.
PG  - 321-5
LID - 10.1007/s12291-015-0529-6 [doi]
AB  - The activity of enzymes of glycolysis has been studied in erythrocytes from 
      type-II diabetic patients in comparison with control. RBC lysate was the source 
      of enzymes. In the diabetics the hexokinase (HK) activity increased 50 % while 
      activities of phosphoglucoisomerase (PGI), phosphofructokinase (PFK) and aldolase 
      (ALD) decreased by 37, 75 and 64 % respectively but were still several folds 
      higher than that of HK. Hence, it is possible that in the diabetic erythrocytes 
      the process of glycolysis could proceed in an unimpaired or in fact may be 
      augmented due to increased levels of G6P. The lactate dehydrogenase (LDH) 
      activity was comparatively high in both the groups; the diabetic group showed 
      85 % increase. In control group the HK, PFK and ALD activities showed strong 
      positive correlation with blood sugar level while PGI activity did not show any 
      correlation. In the diabetic group only PFK activity showed positive correlation. 
      The LDH activity only in the control group showed positive correlation with 
      marginal increase with increasing concentrations of glucose.
FAU - Mali, Aniket V
AU  - Mali AV
AD  - Center for Innovation in Nutrition, Health and Disease, Interactive Research 
      School for Health Affairs, Bharati Vidyapeeth Deemed University, Dhankawadi, 
      Katraj, Pune, Maharashtra 411 043 India.
FAU - Bhise, Sunita S
AU  - Bhise SS
AD  - Center for Innovation in Nutrition, Health and Disease, Interactive Research 
      School for Health Affairs, Bharati Vidyapeeth Deemed University, Dhankawadi, 
      Katraj, Pune, Maharashtra 411 043 India.
FAU - Hegde, Mahabaleshwar V
AU  - Hegde MV
AD  - Center for Innovation in Nutrition, Health and Disease, Interactive Research 
      School for Health Affairs, Bharati Vidyapeeth Deemed University, Dhankawadi, 
      Katraj, Pune, Maharashtra 411 043 India.
FAU - Katyare, Surendra S
AU  - Katyare SS
AD  - Center for Innovation in Nutrition, Health and Disease, Interactive Research 
      School for Health Affairs, Bharati Vidyapeeth Deemed University, Dhankawadi, 
      Katraj, Pune, Maharashtra 411 043 India.
LA  - eng
PT  - Journal Article
DEP - 20151109
PL  - India
TA  - Indian J Clin Biochem
JT  - Indian journal of clinical biochemistry : IJCB
JID - 8708303
PMC - PMC4910847
OTO - NOTNLM
OT  - Aldolase
OT  - Diabetic erythrocytes
OT  - Hexokinase
OT  - Lactate dehydrogenase
OT  - Phosphofructokinase
OT  - Phosphoglucoisomerase
EDAT- 2016/07/07 06:00
MHDA- 2016/07/07 06:01
PMCR- 2017/07/01
CRDT- 2016/07/07 06:00
PHST- 2015/09/11 00:00 [received]
PHST- 2015/09/21 00:00 [accepted]
PHST- 2016/07/07 06:00 [entrez]
PHST- 2016/07/07 06:00 [pubmed]
PHST- 2016/07/07 06:01 [medline]
PHST- 2017/07/01 00:00 [pmc-release]
AID - 529 [pii]
AID - 10.1007/s12291-015-0529-6 [doi]
PST - ppublish
SO  - Indian J Clin Biochem. 2016 Jul;31(3):321-5. doi: 10.1007/s12291-015-0529-6. Epub 
      2015 Nov 9.