PMID- 27382607
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160706
LR  - 20200930
IS  - 2356-7872 (Print)
IS  - 2356-7872 (Electronic)
IS  - 2356-7872 (Linking)
VI  - 2014
DP  - 2014
TI  - Hydroxyapatite-Based Colloidal Gels Facilitate the Proliferation and Migration of 
      Chondrocytes and the Adhesion of Umbilical Cord Mesenchymal Stem Cells.
PG  - 935689
LID - 10.1155/2014/935689 [doi]
LID - 935689
AB  - Collective movement of cells that have been delivered on biomaterials for 
      transplantation purposes would be a desirable attribute that would promote wound 
      healing, cell proliferation, and eventual growth and regeneration of damaged 
      organs. We hypothesized that colloidal gels made from hydroxyapatite (HA) and 
      poly(D,L-lactic-co-glycolic acid) (PLGA) particles will be conducive to the 
      growth and migration of porcine chondrocytes, will allow the adhesion of human 
      umbilical cord mesenchymal stem cells, and will have negligible effects on the 
      cell cycle of these cells. Then, we performed experiments designed to assess the 
      viability and migratory properties of porcine chondrocytes studded on nanosized 
      HA/PLGA particles. Our experiments show that porcine chondrocytes migrated in and 
      around a hydroxyapatite-based biomaterial that could be described as a colloidal 
      gel. Cells in the colloidal gel demonstrated unidirectional movement. Cells were 
      seen to be extending lamellae and were followed by other cells.
FAU - Jamal, Syed A
AU  - Jamal SA
AD  - Division of Molecular Biosciences, University of Kansas, Haworth Hall, 1200 
      Sunnyside Avenue, Lawrence, KS 66045, USA; Rockhurst University, Kansas City, MO 
      64109, USA; Ascend Technology, Dallas, TX 75034, USA.
FAU - Ye, Qiang
AU  - Ye Q
AD  - School of Engineering, University of Kansas, Lawrence, KS 66045, USA.
LA  - eng
PT  - Journal Article
DEP - 20141229
PL  - United States
TA  - Int Sch Res Notices
JT  - International scholarly research notices
JID - 101641951
PMC - PMC4897378
EDAT- 2014/01/01 00:00
MHDA- 2014/01/01 00:01
PMCR- 2014/12/29
CRDT- 2016/07/07 06:00
PHST- 2014/07/22 00:00 [received]
PHST- 2014/10/26 00:00 [revised]
PHST- 2014/10/27 00:00 [accepted]
PHST- 2016/07/07 06:00 [entrez]
PHST- 2014/01/01 00:00 [pubmed]
PHST- 2014/01/01 00:01 [medline]
PHST- 2014/12/29 00:00 [pmc-release]
AID - 10.1155/2014/935689 [doi]
PST - epublish
SO  - Int Sch Res Notices. 2014 Dec 29;2014:935689. doi: 10.1155/2014/935689. 
      eCollection 2014.