PMID- 27382957
OWN - NLM
STAT- MEDLINE
DCOM- 20180103
LR  - 20180514
IS  - 1421-9697 (Electronic)
IS  - 0250-6807 (Linking)
VI  - 69
IP  - 1
DP  - 2016
TI  - Brain-Derived Neurotrophic Factor in Children and Adolescents with Cirrhosis Due 
      to Biliary Atresia.
PG  - 1-8
LID - 10.1159/000447364 [doi]
AB  - BACKGROUND: The nutritional status in patients with cirrhosis is not so easy to 
      assess properly. Considering the relationship between brain-derived neurotrophic 
      factor (BDNF) and energy homeostasis, the main aim of this study was to evaluate 
      the concentration of BDNF in children and adolescents with cirrhosis due to 
      biliary atresia (BA) and correlate it with their nutritional status. METHODS: 
      Fifty-three children and adolescents with cirrhosis due to BA and 33 healthy 
      controls were enrolled in this study. Nutritional status was evaluated using 
      anthropometric parameters, and serum BDNF was measured by ELISA. Spearman 
      coefficient was used to evaluate the correlation between variables. RESULTS: In 
      the cirrhosis group, 28.8% were undernourished and in the control group, 100% 
      were well-nourished. BDNF median values for the control and cirrhosis group were 
      28.5 and 9.0 pg/ml respectively. BDNF and platelets were positively associated 
      with both Standard Deviation Score (SDS) for height-for-age ratio and SDS for 
      triceps skinfold thickness-for-age ratio. CONCLUSIONS: Considering these 
      associations, BDNF may be an indirect biomarker of nutritional status in children 
      and adolescents with chronic liver disease. Further studies must be conducted to 
      clarify the role of BDNF in this population.
CI  - (c) 2016 S. Karger AG, Basel.
FAU - Wilasco, Maria Ines A
AU  - Wilasco MI
AD  - Experimental Laboratory of Gastroenterology and Hepatology, Research Center, 
      Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil.
FAU - Uribe-Cruz, Carolina
AU  - Uribe-Cruz C
FAU - Santetti, Daniele
AU  - Santetti D
FAU - Pfaffenseller, Bianca
AU  - Pfaffenseller B
FAU - Dornelles, Cristina T L
AU  - Dornelles CT
FAU - da Silveira, Themis R
AU  - da Silveira TR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160707
PL  - Switzerland
TA  - Ann Nutr Metab
JT  - Annals of nutrition & metabolism
JID - 8105511
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adolescent
MH  - Biliary Atresia/*complications
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Child
MH  - Child Health Services
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Infant
MH  - Liver Cirrhosis/*blood
MH  - Male
MH  - Nutritional Status
MH  - Predictive Value of Tests
MH  - Severity of Illness Index
EDAT- 2016/07/08 06:00
MHDA- 2018/01/04 06:00
CRDT- 2016/07/08 06:00
PHST- 2015/09/30 00:00 [received]
PHST- 2016/05/25 00:00 [accepted]
PHST- 2016/07/08 06:00 [entrez]
PHST- 2016/07/08 06:00 [pubmed]
PHST- 2018/01/04 06:00 [medline]
AID - 000447364 [pii]
AID - 10.1159/000447364 [doi]
PST - ppublish
SO  - Ann Nutr Metab. 2016;69(1):1-8. doi: 10.1159/000447364. Epub 2016 Jul 7.