PMID- 27383119
OWN - NLM
STAT- MEDLINE
DCOM- 20170526
LR  - 20181202
IS  - 1414-431X (Electronic)
IS  - 0100-879X (Print)
IS  - 0100-879X (Linking)
VI  - 49
IP  - 7
DP  - 2016 Jul 4
TI  - Meta-analysis of the efficacy of proton pump inhibitors for the symptoms of 
      laryngopharyngeal reflux.
LID - S0100-879X2016000700704 [pii]
LID - 10.1590/1414-431X20165149 [doi]
LID - e5149
AB  - The objective of this study was to perform a systematic review and meta-analysis 
      to assess the effectiveness of proton pump inhibitors (PPI) for reflux disease in 
      adult patients with laryngopharyngeal symptoms. A comprehensive search of 
      Cochrane Library, EMBASE, Ovid EBM Reviews, and PubMed was performed for 
      English-language literature about laryngopharyngeal reflux (LPR), in September 
      2014. The papers were filtered using pre-defined inclusion and exclusion 
      criteria. Eight papers were identified and included in this meta-analysis. The 
      sample comprised a pooled total of 370 patients, of which 210 and 160 patients 
      took PPIs and placebo, respectively. The difference between PPIs and placebo 
      groups in overall improvement of symptoms in adult patients with LPR was not 
      statistically significant (RR=1.22; 95%CI=0.93-1.58; P=0.149). The difference in 
      cough improvement was also not significant between PPIs and placebo groups 
      (RR=0.65; 95%CI=0.30-1.41; P=0.279).
FAU - Liu, C
AU  - Liu C
AD  - Department of Otolaryngology, Ji'ning First People's Hospital of Shandong 
      Province, Ji'ning, Shandong, China.
FAU - Wang, H
AU  - Wang H
AD  - Department of Pediatric Dentistry, Ji'ning Stomatological Hospital of Shandong 
      Province, Ji'ning, Shandong, China.
FAU - Liu, K
AU  - Liu K
AD  - Department of Otolaryngology, Ping'du People's Hospital of Shandong Province, 
      Ping'du, Shandong, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
PL  - Brazil
TA  - Braz J Med Biol Res
JT  - Brazilian journal of medical and biological research = Revista brasileira de 
      pesquisas medicas e biologicas
JID - 8112917
RN  - 0 (2-Pyridinylmethylsulfinylbenzimidazoles)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - 2-Pyridinylmethylsulfinylbenzimidazoles/*therapeutic use
MH  - Adult
MH  - Female
MH  - Humans
MH  - Laryngopharyngeal Reflux/*drug therapy
MH  - Male
MH  - Placebo Effect
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Treatment Outcome
PMC - PMC4942224
EDAT- 2016/07/08 06:00
MHDA- 2017/05/27 06:00
PMCR- 2016/07/04
CRDT- 2016/07/08 06:00
PHST- 2015/11/04 00:00 [received]
PHST- 2016/04/28 00:00 [accepted]
PHST- 2016/07/08 06:00 [entrez]
PHST- 2016/07/08 06:00 [pubmed]
PHST- 2017/05/27 06:00 [medline]
PHST- 2016/07/04 00:00 [pmc-release]
AID - S0100-879X2016000700704 [pii]
AID - 10.1590/1414-431X20165149 [doi]
PST - ppublish
SO  - Braz J Med Biol Res. 2016 Jul 4;49(7):e5149. doi: 10.1590/1414-431X20165149.