PMID- 27384158
OWN - NLM
STAT- MEDLINE
DCOM- 20180207
LR  - 20181113
IS  - 2005-9256 (Electronic)
IS  - 1598-2998 (Print)
IS  - 1598-2998 (Linking)
VI  - 49
IP  - 1
DP  - 2017 Jan
TI  - Adjuvant Chemotherapy for Advanced Gastric Cancer in Elderly and Non-elderly 
      Patients: Meta-Analysis of Randomized Controlled Trials.
PG  - 263-273
LID - 10.4143/crt.2016.054 [doi]
AB  - PURPOSE: This study evaluated the benefits of adjuvant chemotherapy on elderly 
      patients with advanced gastric cancer (AGC) using meta-analysis of well-designed 
      randomized controlled clinical studies. MATERIALS AND METHODS: PubMed, Embase, 
      and Cochrane were searched to retrieve clinical studies evaluating the benefits 
      of adjuvant chemotherapy in the elderly with AGC. Hazards ratios (HRs) with 95% 
      confidence intervals (CIs) were pooled across studies using a fixed-effects 
      model. RESULTS: Two studies were included in this meta-analysis to estimate HR 
      for the overall survival (OS), and relapse-free survival (RFS) between adjuvant 
      chemotherapy and surgery in elderly and non-elderly patients. HR for OS in the 
      elderly and non-elderly was 0.745 (95% CI, 0.552 to 1.006, p=0.055) and 0.636 
      (95% CI, 0.522 to 0.776; p < 0.001), respectively, which showed no heterogeneity 
      regarding HR between the two groups (p(interaction)=0.389). HR for RFS in the 
      elderly and non-elderly was 0.613 (95% CI, 0.466 to 0.806; p < 0.001) and 0.633 
      (95% CI, 0.533 to 0.753; p < 0.001), respectively (p(interaction)=0.846). 
      CONCLUSION: Meta-analysis suggests that the benefit of adjuvant chemotherapy to 
      the elderly is not big enough to reach statistical significance while the HR for 
      OS is less than 1 (0.745) and no heterogeneity are observed regarding the HR 
      between the elderly and non-elderly patients.
FAU - Chang, Seong-Hwan
AU  - Chang SH
AD  - Department of Surgery, Konkuk University School of Medicine, Seoul, Korea.
FAU - Kim, Soo-Nyung
AU  - Kim SN
AD  - Department of Obstetrics and Gynecology, Konkuk University School of Medicine, 
      Seoul, Korea.
FAU - Choi, Hye Jung
AU  - Choi HJ
AD  - Department of Internal Medicine, Institute of Health Sciences, Gyeongsang 
      National University School of Medicine, Jinju, Korea.
FAU - Park, Misuk
AU  - Park M
AD  - Medical Library, Institute of Health Sciences, Gyeongsang National University 
      School of Medicine, Jinju, Korea.
FAU - Kim, Rock Bum
AU  - Kim RB
AD  - Department of Preventive Medicine and Environmental Health, Institute of Health 
      Sciences, Gyeongsang National University School of Medicine, Jinju, Korea.
FAU - Go, Se-Il
AU  - Go SI
AD  - Department of Internal Medicine, Institute of Health Sciences, Gyeongsang 
      National University School of Medicine, Jinju, Korea.
FAU - Lee, Won Sup
AU  - Lee WS
AD  - Department of Internal Medicine, Institute of Health Sciences, Gyeongsang 
      National University School of Medicine, Jinju, Korea.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20160705
PL  - Korea (South)
TA  - Cancer Res Treat
JT  - Cancer research and treatment
JID - 101155137
SB  - IM
MH  - Age Factors
MH  - Chemotherapy, Adjuvant/adverse effects/methods
MH  - Humans
MH  - Neoplasm Staging
MH  - Proportional Hazards Models
MH  - Randomized Controlled Trials as Topic
MH  - Stomach Neoplasms/*drug therapy/mortality/pathology
MH  - Treatment Outcome
PMC - PMC5266393
OTO - NOTNLM
OT  - Adjuvant chemotherapy
OT  - Aged
OT  - Meta-analysis
OT  - Stomach neoplasms
COIS- relevant to this article was not reported.
EDAT- 2016/07/08 06:00
MHDA- 2018/02/08 06:00
PMCR- 2017/01/01
CRDT- 2016/07/08 06:00
PHST- 2016/02/04 00:00 [received]
PHST- 2016/05/27 00:00 [accepted]
PHST- 2016/07/08 06:00 [pubmed]
PHST- 2018/02/08 06:00 [medline]
PHST- 2016/07/08 06:00 [entrez]
PHST- 2017/01/01 00:00 [pmc-release]
AID - crt.2016.054 [pii]
AID - crt-2016-054 [pii]
AID - 10.4143/crt.2016.054 [doi]
PST - ppublish
SO  - Cancer Res Treat. 2017 Jan;49(1):263-273. doi: 10.4143/crt.2016.054. Epub 2016 
      Jul 5.