PMID- 2738427
OWN - NLM
STAT- MEDLINE
DCOM- 19890809
LR  - 20110727
IS  - 0021-5325 (Print)
IS  - 0021-5325 (Linking)
VI  - 63
IP  - 4
DP  - 1989 Apr
TI  - [HLA phenotype in patients with osteosarcoma].
PG  - 269-73
AB  - Nineteen patients with typical osteosarcoma were studied for evidence of 
      association with human leukocyte antigen (HLA) phenotypes. HLA-A11 was detected 
      in nine of 19 patients (47.4%) compared with 16.9% of 235 controls (chi 2 " 
      10.861, p less than 0.001), which yielded an odds ratio of 4.523. The positive 
      rate of HLA-A11 was significantly increased in the patients. Interestingly, five 
      of seven patients with poor prognosis had HLA-A11, compared with two of nine 
      disease-free patients, 18 months after the initial treatment. These data suggest 
      that major histocompatibility complex (MHC)-linked genes determines 
      susceptibility to the occurrence of osteosarcoma and its prognosis.
FAU - Shimizu, T
AU  - Shimizu T
AD  - Department of Orthopaedic Surgery, Gunma University School of Medicine, Maebashi, 
      Japan.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Nihon Seikeigeka Gakkai Zasshi
JT  - Nihon Seikeigeka Gakkai zasshi
JID - 0413716
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Bone Neoplasms/*genetics/immunology
MH  - Female
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Male
MH  - Osteosarcoma/*genetics/immunology
MH  - Phenotype
MH  - Prognosis
EDAT- 1989/04/01 00:00
MHDA- 1989/04/01 00:01
CRDT- 1989/04/01 00:00
PHST- 1989/04/01 00:00 [pubmed]
PHST- 1989/04/01 00:01 [medline]
PHST- 1989/04/01 00:00 [entrez]
PST - ppublish
SO  - Nihon Seikeigeka Gakkai Zasshi. 1989 Apr;63(4):269-73.