PMID- 27384414
OWN - NLM
STAT- MEDLINE
DCOM- 20171108
LR  - 20220318
IS  - 1532-7558 (Electronic)
IS  - 1070-5503 (Linking)
VI  - 24
IP  - 1
DP  - 2017 Feb
TI  - Psychosocial and Physiological Predictors of Mortality in Patients of Heart 
      Failure: Independent Effects of Marital Status and C-Reactive Protein.
PG  - 83-91
LID - 10.1007/s12529-016-9579-2 [doi]
AB  - PURPOSE: Few studies have examined the interplay between psychosocial and 
      physiological variables in prediction of mortality in heart failure (HF) 
      patients. This study investigated the prospective influence of marital status, 
      social support, depression, and C-reactive protein (CRP) on the mortality of 
      patients with chronic HF. In addition, it examined whether there was a mediating 
      relationship between social support and marital status and whether depression and 
      inflammation influenced one another to predict mortality of HF patients. METHODS: 
      The participants were 220 HF patients, among whom 48 were deceased over an 
      average of 4.60 years. A number of psychosocial and biomedical variables were 
      examined for their associations with mortality and their relationships between 
      each other in hierarchical logistic regression analyses. RESULTS: After adjusting 
      for New York Heart Association (NYHA) class, age, and gender, being unmarried 
      predicted mortality (OR = 2.80, p = 0.004), whereas perceived social support did 
      not. Higher CRP was not associated with depression, and it independently 
      predicted mortality (OR = 1.92, p = 0.030). Depression predicted mortality only 
      in the univariate analysis (OR = 1.02, p = 0.030), but the association was no 
      longer significant either after removing somatic items or after adjusting for 
      covariates. In the combined multivariate model, marital status (OR = 2.20, 
      p = 0.047), CRP (OR = 1.91, p = 0.035), and NYHA class (OR = 2.41, p = 0.001) 
      independently predicted mortality. CONCLUSIONS: Monitoring chronic HF patients 
      who are unmarried, with elevated inflammation, or in higher NYHA class may help 
      identify those at greater mortality risk to implement targeted intervention.
FAU - Shen, Biing-Jiun
AU  - Shen BJ
AUID- ORCID: 0000-0001-5733-0869
AD  - Division of Psychology, Nanyang Technological University, 14 Nanyang Drive, 
      HSS04-02, Singapore, 637332, Singapore. bshen@alumni.uchicago.edu.
AD  - Department of Psychological and Brain Sciences, University of Delaware, Newark, 
      DE, USA. bshen@alumni.uchicago.edu.
FAU - Xu, Yue
AU  - Xu Y
AD  - Division of Psychology, Nanyang Technological University, 14 Nanyang Drive, 
      HSS04-02, Singapore, 637332, Singapore.
FAU - Eisenberg, Stacy
AU  - Eisenberg S
AD  - VA Greater Los Angeles Healthcare Center, Los Angeles, CA, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Behav Med
JT  - International journal of behavioral medicine
JID - 9421097
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - C-Reactive Protein/*analysis
MH  - Depression/complications
MH  - Female
MH  - Heart Failure/mortality/*psychology
MH  - Humans
MH  - Inflammation/complications
MH  - Male
MH  - *Marital Status
MH  - Middle Aged
MH  - Prospective Studies
MH  - *Social Support
OTO - NOTNLM
OT  - C-reactive protein
OT  - Depression
OT  - Heart failure
OT  - Marital status
OT  - Mortality
OT  - Social support
EDAT- 2016/07/08 06:00
MHDA- 2017/11/09 06:00
CRDT- 2016/07/08 06:00
PHST- 2016/07/08 06:00 [pubmed]
PHST- 2017/11/09 06:00 [medline]
PHST- 2016/07/08 06:00 [entrez]
AID - 10.1007/s12529-016-9579-2 [pii]
AID - 10.1007/s12529-016-9579-2 [doi]
PST - ppublish
SO  - Int J Behav Med. 2017 Feb;24(1):83-91. doi: 10.1007/s12529-016-9579-2.