PMID- 27384856
OWN - NLM
STAT- MEDLINE
DCOM- 20170106
LR  - 20171018
IS  - 0485-1439 (Print)
IS  - 0485-1439 (Linking)
VI  - 57
IP  - 6
DP  - 2016 Jun
TI  - [Spontaneous splenic rupture in a patient with light-chain deposition disease 
      undergoing autologous peripheral blood stem cell transplantation].
PG  - 754-9
LID - 10.11406/rinketsu.57.754 [doi]
AB  - Light-chain deposition disease (LCDD) is a rare plasma cell neoplasm that 
      secretes an abnormal immunoglobulin light chain, which is deposited in tissues, 
      leading to organ dysfunction. Spontaneous splenic rupture is a rare and 
      life-threatening complication of treatment with granulocyte colony-stimulating 
      factor (G-CSF). Herein, we describe spontaneous splenic rupture after the 
      administration of lenograstim to a patient with LCDD undergoing autologous stem 
      cell transplantation (ASCT). The patient was successfully treated by 
      transcatheter embolization of the splenic artery, and long-term stringent 
      complete remission was attained. Plasma cell neoplasms, including multiple 
      myeloma with amyloidosis, are among the most commonly reported conditions 
      associated with spontaneous splenic rupture in patients undergoing ASCT. This 
      finding suggests that, in addition to the effect of G-CSF on the spleen, a 
      combination of factors, including tissue vulnerability induced by the 
      infiltration of abnormal immunoglobulins, may be involved in the pathogenesis of 
      spontaneous splenic rupture. Notably, splenomegaly is not always evident in these 
      patients. Surgical treatment may not be an option, because of severe 
      myelosuppression, and thus less invasive treatment using transcatheter 
      embolization may be feasible.
FAU - Haji, Shojiro
AU  - Haji S
AD  - Department of Hematology, Iizuka Hospital.
FAU - Kiyasu, Junichi
AU  - Kiyasu J
FAU - Tachikawa, Yoshimichi
AU  - Tachikawa Y
FAU - Toyonaga, Jiro
AU  - Toyonaga J
FAU - Ikeda, Motohiko
AU  - Ikeda M
FAU - Tsuda, Mariko
AU  - Tsuda M
FAU - Tsukamoto, Yasuhiro
AU  - Tsukamoto Y
FAU - Kozuru, Mitsuo
AU  - Kozuru M
FAU - Yufu, Yuji
AU  - Yufu Y
LA  - jpn
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Rinsho Ketsueki
JT  - [Rinsho ketsueki] The Japanese journal of clinical hematology
JID - 2984782R
SB  - IM
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Paraproteinemias/*complications
MH  - Peripheral Blood Stem Cell Transplantation/*adverse effects
MH  - Rupture, Spontaneous/drug therapy/*etiology
MH  - Splenic Rupture/drug therapy/*etiology
MH  - Transplantation, Autologous/adverse effects
MH  - Treatment Outcome
EDAT- 2016/07/08 06:00
MHDA- 2017/01/07 06:00
CRDT- 2016/07/08 06:00
PHST- 2016/07/08 06:00 [entrez]
PHST- 2016/07/08 06:00 [pubmed]
PHST- 2017/01/07 06:00 [medline]
AID - 10.11406/rinketsu.57.754 [doi]
PST - ppublish
SO  - Rinsho Ketsueki. 2016 Jun;57(6):754-9. doi: 10.11406/rinketsu.57.754.