PMID- 27386832
OWN - NLM
STAT- MEDLINE
DCOM- 20171116
LR  - 20181202
IS  - 1531-7013 (Electronic)
IS  - 1087-2418 (Linking)
VI  - 21
IP  - 4
DP  - 2016 Aug
TI  - Non-human leukocyte antigen-specific antibodies in thoracic transplantation.
PG  - 350-4
LID - 10.1097/MOT.0000000000000330 [doi]
AB  - PURPOSE OF REVIEW: Development of donor human leukocyte antigen (HLA)-specific 
      antibodies is associated with graft loss, yet the role of non-HLA antibodies in 
      solid organ transplant needs to be further defined. It is suggested that HLA 
      antibodies and non-HLA antibodies collaborate together to impact graft outcome. 
      This review focuses on the latest findings on antibodies against these non-HLA 
      antigens in thoracic organ transplant. RECENT FINDINGS: These non-HLA antigens 
      include signaling proteins expressed on the cell surface, such as angiotensin II 
      type 1 receptor (AT1R), endothelin type A receptor, and structure proteins, such 
      as myosin, vimentin, and Kalpha1 tubulin, and extracellular matrix protein collagen. 
      Antibodies against these antigens may impact the allograft in different ways. 
      Although these non-HLA antibodies can damage the allograft through 
      complement-mediated or cell-mediated cytotoxicity, antibodies against AT1R and 
      endothelin type A receptor can also alter the endothelial cell function by 
      activating intracellular signals. The presence of these non-HLA antibodies may 
      predispose the patient to develop HLA-specific antibodies. Recently, it has been 
      shown patients with AT1R antibodies pretransplant have a higher chance to develop 
      de-novo donor-specific HLA antibodies. SUMMARY: The findings suggest it is 
      important to stratify the patient's immunologic risk by assessing both the HLA 
      and non-HLA-specific antibodies.
FAU - Reinsmoen, Nancy L
AU  - Reinsmoen NL
AD  - HLA Laboratory, Cedars-Sinai Medical Center, Comprehensive Transplant Center, Los 
      Angeles, California, USA.
FAU - Zhang, Xiaohai
AU  - Zhang X
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Organ Transplant
JT  - Current opinion in organ transplantation
JID - 9717388
RN  - 0 (Antibodies)
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Antibodies
MH  - HLA Antigens/*immunology
MH  - Histocompatibility Antigens Class II
MH  - Humans
MH  - Thoracic Surgical Procedures/*methods
MH  - Tissue Donors
MH  - Transplantation, Homologous/*methods
EDAT- 2016/07/09 06:00
MHDA- 2017/11/29 06:00
CRDT- 2016/07/09 06:00
PHST- 2016/07/09 06:00 [entrez]
PHST- 2016/07/09 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
AID - 00075200-201608000-00003 [pii]
AID - 10.1097/MOT.0000000000000330 [doi]
PST - ppublish
SO  - Curr Opin Organ Transplant. 2016 Aug;21(4):350-4. doi: 
      10.1097/MOT.0000000000000330.