PMID- 27388951
OWN - NLM
STAT- MEDLINE
DCOM- 20170206
LR  - 20221207
IS  - 1941-9260 (Electronic)
IS  - 0032-5481 (Linking)
VI  - 128
IP  - 8
DP  - 2016 Nov
TI  - Choroidal and macular thickness changes in type 1 diabetes mellitus patients 
      without diabetic retinopathy.
PG  - 755-760
AB  - OBJECTIVES: To explore choroidal thickness (ChT) and retinal thickness (RT) 
      changes in patients with type 1 diabetes mellitus (DM). METHODS: Sixty patients 
      with Type 1 DM and 60 age- and sex-matched healthy controls were included in this 
      prospective case-control clinical study. All patients underwent a complete 
      ophthalmological examination. ChT of each participant was measured at the fovea 
      and horizontal nasal and temporal quadrants at 500-microm intervals to 1500 microm from 
      the foveola using spectral-domain optical coherence tomography (SD-OCT). Age, 
      gender, disease duration, serum glycosylated hemoglobin (HbA1c), fasting glucose 
      level, axial length (AL) and refractive error were noted and analyzed. RESULTS: 
      Mean disease duration, mean HbA1c and mean fasting blood glucose in diabetic 
      patients were 6.1+/-2.8 years, (8.9+/-0.9)% and 287.5+/-69.1 mg/dl, respectively. Age, 
      gender, AL, spherical equivalent differences between the patients and subjects 
      were insignificant (p>0.05). Subfoveal ChT, nasal quadrant ChT measurements, 
      temporal 1500 microm and mean nasal ChT were significantly lower in diabetic patients 
      (p<0.05 for all). Temporal 500 microm and 1000 microm ChT measurements, mean temporal 
      ChT, average ChT, central macular thickness and average macular thickness did not 
      differ significantly between the groups (p>0.05 for all). CONCLUSION: This study 
      showed that there is choroidal thinning in young Type 1 diabetic patients with 
      early period of disease duration without diabetic retinopathy nor any other 
      systemic diseases. Choroidal changes in type 1 DM seem to begin at nasal and 
      distal temporal retina. These results need to be verified by larger and 
      longitudinal studies.
FAU - Yolcu, Umit
AU  - Yolcu U
AD  - a Department of Ophthalmology , Mevki Military Hospital , Ankara , Turkey.
FAU - Cagiltay, Eylem
AU  - Cagiltay E
AD  - b Department of Endocrinology , Izmir Military Hospital , Izmir , Turkey.
FAU - Toyran, Sami
AU  - Toyran S
AD  - c Department of Ophthalmology , Izmir Military Hospital , Izmir , Turkey.
FAU - Akay, Fahrettin
AU  - Akay F
AD  - c Department of Ophthalmology , Izmir Military Hospital , Izmir , Turkey.
FAU - Uzun, Salih
AU  - Uzun S
AD  - d Department of Ophthalmology , Etimesgut Military Hospital , Ankara , Turkey.
FAU - Gundogan, Fatih C
AU  - Gundogan FC
AD  - e Department of Ophthalmology , GATA Medical School , Ankara , Turkey.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20160720
PL  - England
TA  - Postgrad Med
JT  - Postgraduate medicine
JID - 0401147
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Age of Onset
MH  - Axial Length, Eye
MH  - Case-Control Studies
MH  - Choroid/*physiopathology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 1/*physiopathology
MH  - Female
MH  - Fovea Centralis
MH  - Glycated Hemoglobin
MH  - Humans
MH  - Macula Lutea/*physiopathology
MH  - Male
MH  - Prospective Studies
MH  - Refractive Errors
MH  - Retina/physiopathology
MH  - Sex Factors
MH  - Tomography, Optical Coherence
MH  - Young Adult
OTO - NOTNLM
OT  - Choroidal thickness
OT  - diabetes mellitus
OT  - optical coherence tomography
OT  - retinal thickness
EDAT- 2016/07/09 06:00
MHDA- 2017/02/07 06:00
CRDT- 2016/07/09 06:00
PHST- 2016/07/09 06:00 [pubmed]
PHST- 2017/02/07 06:00 [medline]
PHST- 2016/07/09 06:00 [entrez]
AID - 10.1080/00325481.2016.1210475 [doi]
PST - ppublish
SO  - Postgrad Med. 2016 Nov;128(8):755-760. doi: 10.1080/00325481.2016.1210475. Epub 
      2016 Jul 20.