PMID- 27389068
OWN - NLM
STAT- MEDLINE
DCOM- 20180124
LR  - 20181202
IS  - 2169-141X (Electronic)
IS  - 2169-1401 (Linking)
VI  - 45
IP  - 6
DP  - 2017 Sep
TI  - PLGA nanoparticles for ocular delivery of loteprednol etabonate: a corneal 
      penetration study.
PG  - 1-9
LID - 10.1080/21691401.2016.1203794 [doi]
AB  - The purpose of the present study was to develop loteprednol etabonate (LE) loaded 
      poly(d,l-lactide co-glycolide) (PLGA) nanoparticles (NPs) and study their 
      penetration profile into the excised goat cornea. In the present study, LE loaded 
      PLGA NPs were prepared by solvent evaporation with high speed homogenization 
      method and the penetration profile was studied using confocal laser scanning 
      microscopy (CLSM). Rhodamine (Rd) was used as a fluorescent marker to prepare 
      Rd-LE-PLGA-NPs. The NPs were characterized for particle size, X-ray diffraction 
      (XRD), differential scanning calorimetry (DSC), transmission electron microscopy 
      (TEM), drug entrapment, and permeation profile. Intense fluorescence observed 
      across the depths of goat corneal tissue suggested an improved penetration 
      profile of NPs. The entrapment efficiency and mean diameter of the optimized 
      formulation (F5) were found to be 96.31 +/- 1.68% and 167.6 +/- 0.37 nm, 
      respectively. These findings indicate that LE loaded PLGA NPs may serve as a 
      potential drug carrier for ocular administration in eye disease.
FAU - Sah, Abhishek K
AU  - Sah AK
AD  - a University Institute of Pharmacy, Faculty of Technology, Pt. Ravishankar Shukla 
      University , Raipur , Chhattisgarh , India.
FAU - Suresh, Preeti K
AU  - Suresh PK
AD  - a University Institute of Pharmacy, Faculty of Technology, Pt. Ravishankar Shukla 
      University , Raipur , Chhattisgarh , India.
FAU - Verma, Vinod K
AU  - Verma VK
AD  - b State Drug Testing Laboratory, Food and Drugs Administration , Govt. of 
      Chhattisgarh , Raipur , Chhattisgarh , India.
LA  - eng
PT  - Journal Article
DEP - 20160708
PL  - England
TA  - Artif Cells Nanomed Biotechnol
JT  - Artificial cells, nanomedicine, and biotechnology
JID - 101594777
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - YEH1EZ96K6 (Loteprednol Etabonate)
SB  - IM
MH  - Administration, Ophthalmic
MH  - Animals
MH  - Cornea/*metabolism
MH  - Drug Delivery Systems/*methods
MH  - Eye Diseases/drug therapy/metabolism
MH  - Goats
MH  - *Lactic Acid/chemistry/pharmacokinetics/pharmacology
MH  - *Loteprednol Etabonate/chemistry/pharmacokinetics/pharmacology
MH  - *Nanoparticles/chemistry/therapeutic use
MH  - Permeability
MH  - *Polyglycolic Acid/chemistry/pharmacokinetics/pharmacology
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
OTO - NOTNLM
OT  - CLSM
OT  - PLGA
OT  - corneal penetration
OT  - loteprednol etabonate
OT  - nanoparticle
OT  - ocular delivery
EDAT- 2016/07/09 06:00
MHDA- 2018/01/25 06:00
CRDT- 2016/07/09 06:00
PHST- 2016/07/09 06:00 [pubmed]
PHST- 2018/01/25 06:00 [medline]
PHST- 2016/07/09 06:00 [entrez]
AID - 10.1080/21691401.2016.1203794 [doi]
PST - ppublish
SO  - Artif Cells Nanomed Biotechnol. 2017 Sep;45(6):1-9. doi: 
      10.1080/21691401.2016.1203794. Epub 2016 Jul 8.