PMID- 27390987
OWN - NLM
STAT- MEDLINE
DCOM- 20170829
LR  - 20170829
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 220
DP  - 2016 Oct 1
TI  - Importance of papillary muscle infarction detected by cardiac magnetic resonance 
      imaging in predicting cardiovascular events.
PG  - 558-63
LID - S0167-5273(16)31210-4 [pii]
LID - 10.1016/j.ijcard.2016.06.201 [doi]
AB  - BACKGROUND: Recent studies suggest that papillary muscle infarction (PMI) 
      following recent myocardial infarction (MI) correlates with adverse 
      cardiovascular outcomes. The purpose of this study is to determine the prevalence 
      and prognostic significance of PMI by cardiac magnetic resonance (CMR) in a large 
      cohort of patients. METHODS: Retrospective study of patients who underwent CMR 
      between January 2007 and December 2009 were evaluated for the presence of PMI in 
      one or both of the left ventricle papillary muscles. The primary outcome was a 
      time to a combined endpoint of all-cause mortality and worsening heart failure. 
      Secondary outcomes were time to individual components of the combined outcome. 
      RESULTS: 419 patients were included in our analysis, 232 patients (55%) had 
      ischemic cardiomyopathy. Patients were followed at six-month intervals for a 
      median follow-up time of 3.7 (interquartile range (IQR): 1.6; 6.3) years after 
      initial imaging. During this period 196 patients (46.8%) had a primary outcome 
      and 92 patients (22%) died. PM infarct was identified in 204 (48.7%) patients 
      with twice as many posteromedial (PRM) (27%) than anterolateral (ARL) lesions 
      (11%) and a similar number with infarct in both (11%). There was no association 
      between studied outcomes and the presence of PMI in either PRM or ARL PM. The 
      presence of infarct in both PM was a predictor of both the primary outcome (HR 
      1.69, CI[1.01-2.86], p<0.049.) and mortality (HR 1.69, CI[1.01-4.2], p<0.046). 
      CONCLUSION: The presence of infarct in either papillary muscle was not associated 
      with outcomes. However, infarct involving both papillary muscles was associated 
      with worse outcomes.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Ivanov, A
AU  - Ivanov A
AD  - Department of Medicine, New York Methodist Hospital, Brooklyn, NY, United States.
FAU - Bhumireddy, G P
AU  - Bhumireddy GP
AD  - Department of Medicine, New York Methodist Hospital, Brooklyn, NY, United States.
FAU - Dabiesingh, D S
AU  - Dabiesingh DS
AD  - Department of Medicine, New York Methodist Hospital, Brooklyn, NY, United States.
FAU - Khan, S A
AU  - Khan SA
AD  - Department of Medicine, New York Methodist Hospital, Brooklyn, NY, United States.
FAU - Ho, J
AU  - Ho J
AD  - Department of Medicine, New York Methodist Hospital, Brooklyn, NY, United States.
FAU - Krishna, N
AU  - Krishna N
AD  - Department of Medicine, New York Methodist Hospital, Brooklyn, NY, United States.
FAU - Dontineni, N
AU  - Dontineni N
AD  - Department of Medicine, New York Methodist Hospital, Brooklyn, NY, United States.
FAU - Socolow, J A
AU  - Socolow JA
AD  - Department of Medicine, New York Methodist Hospital, Brooklyn, NY, United States.
FAU - Briggs, W M
AU  - Briggs WM
AD  - Department of Statistical Sciences, Cornell University, Ithaca, NY, United 
      States.
FAU - Klem, I
AU  - Klem I
AD  - Department of Medicine, Duke University Medical Center, Durham, NC, United 
      States.
FAU - Sacchi, T J
AU  - Sacchi TJ
AD  - Department of Medicine, New York Methodist Hospital, Brooklyn, NY, United States.
FAU - Heitner, J F
AU  - Heitner JF
AD  - Department of Medicine, New York Methodist Hospital, Brooklyn, NY, United States. 
      Electronic address: jfh9003@nyp.org.
LA  - eng
PT  - Journal Article
DEP - 20160627
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*diagnostic imaging/physiopathology
MH  - Papillary Muscles/*diagnostic imaging/physiopathology
MH  - Predictive Value of Tests
MH  - Retrospective Studies
MH  - Young Adult
OTO - NOTNLM
OT  - CMR
OT  - Cardiovascular outcomes
OT  - Mortality
OT  - Papillary muscle infarct
EDAT- 2016/07/09 06:00
MHDA- 2017/08/30 06:00
CRDT- 2016/07/09 06:00
PHST- 2016/03/09 00:00 [received]
PHST- 2016/05/23 00:00 [revised]
PHST- 2016/06/25 00:00 [accepted]
PHST- 2016/07/09 06:00 [entrez]
PHST- 2016/07/09 06:00 [pubmed]
PHST- 2017/08/30 06:00 [medline]
AID - S0167-5273(16)31210-4 [pii]
AID - 10.1016/j.ijcard.2016.06.201 [doi]
PST - ppublish
SO  - Int J Cardiol. 2016 Oct 1;220:558-63. doi: 10.1016/j.ijcard.2016.06.201. Epub 
      2016 Jun 27.