PMID- 27391387
OWN - NLM
STAT- MEDLINE
DCOM- 20170605
LR  - 20220310
IS  - 1944-7884 (Electronic)
IS  - 1525-4135 (Linking)
VI  - 73
IP  - 4
DP  - 2016 Dec 1
TI  - Metabolic Syndrome After HIV Acquisition in South African Women.
PG  - 438-445
AB  - BACKGROUND: Noncommunicable diseases are common among chronically infected 
      patients with HIV in the developed world, but little is known about these 
      conditions in African cohorts. We assessed the epidemiology of metabolic syndrome 
      among young South African women during the first 3 years after HIV acquisition. 
      METHODS: A total of 160 women were followed prospectively in the CAPRISA 002 
      Acute Infection study. Metabolic syndrome was defined as a constellation of 
      hyperlipidemia, hypertension, hyperglycemia/diabetes, and abdominal obesity. Time 
      trends were assessed using generalized estimation equation models. RESULTS: 
      Median age was 24 years and body mass index 27 kg/m. Prevalence of metabolic 
      syndrome at infection was 8.7% increasing to 19.2% over 36 months (P = 0.001). 
      The proportion of women with body mass index >30 kg/m increased from 34.4% to 
      47.7% (P = 0.004), those with abnormal waist circumference and elevated blood 
      pressure increased from 33.5% to 44.3% (P = 0.060) and 23.8% to 43.9% (P < 
      0.001), respectively. Incidence of metabolic syndrome was 9.13/100 person-years 
      (95% CI: 6.02 to 13.28). Predictors of metabolic syndrome were age (per year 
      increase odds ratio (OR) = 1.12; 95% CI: 1.07 to 1.16), time postinfection (per 
      year OR = 1.47; 95% CI: 1.12 to 1.92), family history of diabetes (OR = 3.13; 95% 
      CI: 1.71 to 5.72), and the human leukocyte antigen (HLA)-B*81:01 allele (OR = 
      2.95; 95% CI: 1.21 to 7.17), whereas any HLA-B*57 or B*58:01 alleles were 
      protective (OR = 0.34; 95% CI: 0.15 to 0.77). HIV-1 RNA (OR = 0.89; 95% CI: 0.62 
      to 1.27) and CD4 count (OR = 1.03; 95% CI: 0.95 to 1.11) did not predict 
      metabolic syndrome. CONCLUSIONS: The high burden of metabolic conditions in young 
      South African HIV-infected women highlights the need to integrate noncommunicable 
      disease and HIV care programs. Interventions to prevent cardiovascular disease 
      must start at HIV diagnosis, rather than later during the disease course.
FAU - Sobieszczyk, Magdalena E
AU  - Sobieszczyk ME
AD  - *Centre for the AIDS Programme of Research in South Africa (CAPRISA), University 
      of KwaZulu-Natal, Durban, South Africa; daggerDivision of Infectious Disease, 
      Department of Medicine, Columbia University, New York, NY; double daggerDepartment of Medical 
      Microbiology, University of KwaZulu-Natal, Durban, South Africa;  section signNational Health 
      Laboratory Service, Durban, South Africa; Divisions of  ||Medical Virology, 
       paragraph signImmunology, Institute of Infectious Diseases and Molecular Medicine, University 
      of Cape Town, South Africa; and #Department of Epidemiology, Mailman School of 
      Public Health, Columbia University, New York, NY.
FAU - Werner, Lise
AU  - Werner L
FAU - Mlisana, Koleka
AU  - Mlisana K
FAU - Naicker, Nivashnee
AU  - Naicker N
FAU - Feinstein, Addi
AU  - Feinstein A
FAU - Gray, Clive M
AU  - Gray CM
FAU - Masson, Lindi
AU  - Masson L
FAU - Passmore, Jo-Ann S
AU  - Passmore JS
FAU - Williamson, Carolyn
AU  - Williamson C
FAU - Abdool Karim, Quarraisha
AU  - Abdool Karim Q
FAU - Abdool Karim, Salim S
AU  - Abdool Karim SS
FAU - Garrett, Nigel J
AU  - Garrett NJ
LA  - eng
GR  - D43 TW000231/TW/FIC NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - J Acquir Immune Defic Syndr
JT  - Journal of acquired immune deficiency syndromes (1999)
JID - 100892005
RN  - 0 (Cytokines)
SB  - IM
MH  - Adult
MH  - Cytokines/blood/metabolism
MH  - Female
MH  - HIV Infections/blood/*complications/*epidemiology
MH  - Humans
MH  - Metabolic Syndrome/blood/*epidemiology/*etiology
MH  - Odds Ratio
MH  - Risk Factors
MH  - South Africa/epidemiology
MH  - Young Adult
EDAT- 2016/10/30 06:00
MHDA- 2017/06/06 06:00
CRDT- 2016/07/09 06:00
PHST- 2016/10/30 06:00 [pubmed]
PHST- 2017/06/06 06:00 [medline]
PHST- 2016/07/09 06:00 [entrez]
AID - 10.1097/QAI.0000000000001123 [doi]
PST - ppublish
SO  - J Acquir Immune Defic Syndr. 2016 Dec 1;73(4):438-445. doi: 
      10.1097/QAI.0000000000001123.