PMID- 27393712
OWN - NLM
STAT- MEDLINE
DCOM- 20170926
LR  - 20171128
IS  - 1520-7560 (Electronic)
IS  - 1520-7552 (Linking)
VI  - 33
IP  - 2
DP  - 2017 Feb
TI  - Serum asymmetric dimethylarginine and arginine levels predict microvascular and 
      macrovascular complications in type 2 diabetes mellitus.
LID - 10.1002/dmrr.2836 [doi]
AB  - BACKGROUND: Increased oxidative stress in diabetes increases nitric oxide (NO) 
      oxidation and low l-arginine (Arg) could further reduce NO and impair vascular 
      function, thereby accelerating, in the long run, vascular complications. We 
      therefore measured Arg and asymmetric dimethylarginine (ADMA) levels in patients 
      with type 2 diabetes mellitus (T2DM) and healthy controls. Additionally, we 
      observed the diabetic individuals over time to see if Arg and asymmetric 
      dimethylarginine predicted T2DM complications. METHODS: We examined baseline 
      serum Arg and ADMA levels in a cohort of 105 participants with type 2 diabetes 
      and compared them with an age- and weight-matched nondiabetic group of 137 
      individuals who served as a reference population. Additionally, we assessed 
      whether Arg and/or ADMA predicted macrovascular and microvascular complications 
      over 6 years of follow-up. RESULTS: Serum Arg was lower in individuals with T2DM 
      than in controls (64 +/- 28 vs 75 +/- 31 mumol/L; P = .009) and inversely related to 
      hemoglobin A1c (r = -0.2; P = .002). Over follow-up, we observed that 
      participants with T2DM in the lowest quartile of Arg had increased risk for the 
      subsequent evolution of nephropathy, peripheral neuropathy, and composite 
      microvascular complications (odds ratio [OR] = 5.5; 95% confidence interval [CI] 
      -1.9 to 16; P = .002). The highest ADMA quartile was associated with increased 
      risk for both microvascular (OR = 4.5; 95% CI -1.4 to 14.1; P = .009) and 
      6.5-year incident macrovascular complications (OR = 8.3; 95% CI 1.9-35.5; 
      P = .004). CONCLUSION: l-Arginine levels are lower in individuals with T2DM than 
      in matched controls. Both low Arg and high ADMA, independent of each other and 
      adjusted for classical risk factors, predict the incidence of microvascular 
      complications.
CI  - Copyright (c) 2016 John Wiley & Sons, Ltd.
FAU - Ganz, Tali
AU  - Ganz T
AD  - Diabetes Unit, Wolfson Medical Center, Holon, Israel.
AD  - Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel.
FAU - Wainstein, Julio
AU  - Wainstein J
AD  - Diabetes Unit, Wolfson Medical Center, Holon, Israel.
AD  - Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel.
FAU - Gilad, Suzan
AU  - Gilad S
AD  - The Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv-Sourasky 
      Medical Center, Tel Aviv, Israel.
FAU - Limor, Rona
AU  - Limor R
AD  - The Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv-Sourasky 
      Medical Center, Tel Aviv, Israel.
FAU - Boaz, Mona
AU  - Boaz M
AD  - Department of Nutrition Sciences, Ariel University, Ariel, Israel.
AD  - Epidemilogy and Research Unit, Wolfson Medical Center, Holon, Israel.
FAU - Stern, Naftali
AU  - Stern N
AD  - Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel.
AD  - The Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv-Sourasky 
      Medical Center, Tel Aviv, Israel.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20161005
PL  - England
TA  - Diabetes Metab Res Rev
JT  - Diabetes/metabolism research and reviews
JID - 100883450
RN  - 0 (Biomarkers)
RN  - 63CV1GEK3Y (N,N-dimethylarginine)
RN  - 94ZLA3W45F (Arginine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Arginine/*analogs & derivatives/*blood
MH  - Biomarkers/*blood
MH  - Cardiovascular Diseases/blood/*diagnosis/etiology
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Diabetes Complications/blood/*diagnosis/etiology
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxidative Stress
MH  - Prognosis
MH  - Prospective Studies
MH  - Risk Factors
MH  - Young Adult
OTO - NOTNLM
OT  - diabetes complications
OT  - metabolic syndrome
OT  - obesity
EDAT- 2016/07/10 06:00
MHDA- 2017/09/28 06:00
CRDT- 2016/07/10 06:00
PHST- 2016/03/27 00:00 [received]
PHST- 2016/06/06 00:00 [revised]
PHST- 2016/06/29 00:00 [accepted]
PHST- 2016/07/10 06:00 [pubmed]
PHST- 2017/09/28 06:00 [medline]
PHST- 2016/07/10 06:00 [entrez]
AID - 10.1002/dmrr.2836 [doi]
PST - ppublish
SO  - Diabetes Metab Res Rev. 2017 Feb;33(2). doi: 10.1002/dmrr.2836. Epub 2016 Oct 5.