PMID- 27394160
OWN - NLM
STAT- MEDLINE
DCOM- 20170628
LR  - 20181113
IS  - 1572-8595 (Electronic)
IS  - 1383-875X (Linking)
VI  - 47
IP  - 2
DP  - 2016 Nov
TI  - Experience with bisoprolol in long-QT1 and long-QT2 syndrome.
PG  - 163-170
AB  - BACKGROUND: The protective effect of beta-blockers in patients with inherited 
      Long-QT syndrome is well established. Recent reports have suggested that 
      beta-blockers are not equally effective in Long-QT (LQT). Bisoprolol is an 
      attractive candidate for use in LQT because of its cardioselective properties and 
      favorable side-effect profile. METHODS: We performed a retrospective cohort study 
      of 114 consecutive patients with gene-positive Long-QT syndrome type 1 (LQT1) or 
      Long-QT syndrome type 2 (LQT2) treated with bisoprolol, nadolol or atenolol with 
      a total of 580 person-years of follow-up. Electrocardiogram (ECG) parameters and 
      cardiac events during follow-up were compared. In addition, exercise treadmill 
      testing was performed in bisoprolol-treated patients. RESULTS: Fifty-nine 
      patients were treated with bisoprolol, 39 with atenolol and 16 with nadolol. 
      Overall, 59 % were females and 62 % had LQT1. Baseline heart rate and corrected 
      QT (QTc) interval were similar between the groups. QTc shortening was observed in 
      individuals on bisoprolol (DeltaQTc -5 +/- 31 ms; p = 0.049) and nadolol (DeltaQTc 
      -13 +/- 16 ms; p = 0.02) but not on atenolol (DeltaQTc +9 +/- 24 ms; p = 0.16). Median 
      follow-up was similar for bisoprolol and nadolol (3 years), but longer for 
      atenolol (6 years; p = 0.03); one cardiac event occurred in the bisoprolol group 
      (1.7 %) and two events occurred in the atenolol group (5.1 %; p = 0.45), whereas 
      none occurred in nadolol-treated patients. Beta-blocker efficacy was not affected 
      by the underlying genotype. The antiadrenergic effect of bisoprolol correlated 
      with the reduction of peak heart rates at exercise testing. CONCLUSIONS: 
      Bisoprolol treatment results in QTc shortening in gene-positive LQT1 and LQT2 
      patients and is well tolerated during long-term administration. The equivalence 
      of bisoprolol for protection from ventricular arrhythmia in LQT patients compared 
      to established beta-blockers remains unknown. Further large-scale studies are 
      required.
FAU - Steinberg, Christian
AU  - Steinberg C
AD  - Heart Rhythm Services, Division of Cardiology, Department of Medicine, University 
      of British Columbia, Vancouver, British Columbia, Canada.
FAU - Padfield, Gareth J
AU  - Padfield GJ
AD  - Heart Rhythm Services, Division of Cardiology, Department of Medicine, University 
      of British Columbia, Vancouver, British Columbia, Canada.
FAU - Al-Sabeq, Basil
AU  - Al-Sabeq B
AD  - Division of Cardiology, Department of Medicine, Western University, London, 
      Ontario, Canada.
FAU - Adler, Arnon
AU  - Adler A
AD  - Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada.
FAU - Yeung-Lai-Wah, John A
AU  - Yeung-Lai-Wah JA
AD  - Heart Rhythm Services, Division of Cardiology, Department of Medicine, University 
      of British Columbia, Vancouver, British Columbia, Canada.
FAU - Kerr, Charles R
AU  - Kerr CR
AD  - Heart Rhythm Services, Division of Cardiology, Department of Medicine, University 
      of British Columbia, Vancouver, British Columbia, Canada.
FAU - Deyell, Marc W
AU  - Deyell MW
AD  - Heart Rhythm Services, Division of Cardiology, Department of Medicine, University 
      of British Columbia, Vancouver, British Columbia, Canada.
FAU - Andrade, Jason G
AU  - Andrade JG
AD  - Heart Rhythm Services, Division of Cardiology, Department of Medicine, University 
      of British Columbia, Vancouver, British Columbia, Canada.
FAU - Bennett, Matthew T
AU  - Bennett MT
AD  - Heart Rhythm Services, Division of Cardiology, Department of Medicine, University 
      of British Columbia, Vancouver, British Columbia, Canada.
FAU - Yee, Raymond
AU  - Yee R
AD  - Division of Cardiology, Department of Medicine, Western University, London, 
      Ontario, Canada.
FAU - Klein, George J
AU  - Klein GJ
AD  - Division of Cardiology, Department of Medicine, Western University, London, 
      Ontario, Canada.
FAU - Green, Martin
AU  - Green M
AD  - Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada.
FAU - Laksman, Zachary W M
AU  - Laksman ZW
AD  - Heart Rhythm Services, Division of Cardiology, Department of Medicine, University 
      of British Columbia, Vancouver, British Columbia, Canada.
FAU - Krahn, Andrew D
AU  - Krahn AD
AD  - Heart Rhythm Services, Division of Cardiology, Department of Medicine, University 
      of British Columbia, Vancouver, British Columbia, Canada.
FAU - Chakrabarti, Santabhanu
AU  - Chakrabarti S
AD  - Heart Rhythm Services, Division of Cardiology, Department of Medicine, University 
      of British Columbia, Vancouver, British Columbia, Canada. 
      SChakrabarti@providencehealth.bc.ca.
AD  - Heart Rhythm Services, St. Paul's Hospital, Suite 211 - 1033 Davie St, Vancouver, 
      BC, V6E 1M7, Canada. SChakrabarti@providencehealth.bc.ca.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Video-Audio Media
DEP - 20160709
PL  - Netherlands
TA  - J Interv Card Electrophysiol
JT  - Journal of interventional cardiac electrophysiology : an international journal of 
      arrhythmias and pacing
JID - 9708966
RN  - 0 (Adrenergic beta-1 Receptor Antagonists)
RN  - 0 (Cardiotonic Agents)
RN  - Y41JS2NL6U (Bisoprolol)
RN  - Long Qt Syndrome 2
SB  - IM
MH  - Adrenergic beta-1 Receptor Antagonists
MH  - Adult
MH  - Bisoprolol/*administration & dosage
MH  - Canada
MH  - Cardiotonic Agents/administration & dosage
MH  - Cohort Studies
MH  - Electrocardiography/*drug effects
MH  - Female
MH  - Heart Rate/drug effects
MH  - Humans
MH  - Long QT Syndrome/diagnosis/*drug therapy
MH  - Male
MH  - Retrospective Studies
MH  - Romano-Ward Syndrome/*diagnosis/*drug therapy
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Beta-blocker
OT  - Bisoprolol
OT  - Channelopathy
OT  - Inherited arrhythmia
OT  - LQT1
OT  - LQT2
OT  - Long-QT
EDAT- 2016/10/27 06:00
MHDA- 2017/06/29 06:00
CRDT- 2016/07/11 06:00
PHST- 2016/03/13 00:00 [received]
PHST- 2016/06/29 00:00 [accepted]
PHST- 2016/10/27 06:00 [pubmed]
PHST- 2017/06/29 06:00 [medline]
PHST- 2016/07/11 06:00 [entrez]
AID - 10.1007/s10840-016-0161-2 [pii]
AID - 10.1007/s10840-016-0161-2 [doi]
PST - ppublish
SO  - J Interv Card Electrophysiol. 2016 Nov;47(2):163-170. doi: 
      10.1007/s10840-016-0161-2. Epub 2016 Jul 9.