PMID- 27396498
OWN - NLM
STAT- MEDLINE
DCOM- 20180301
LR  - 20220408
IS  - 1557-9042 (Electronic)
IS  - 0897-7151 (Linking)
VI  - 34
IP  - 4
DP  - 2017 Feb 15
TI  - Genetics and Other Risk Factors for Past Concussions in Active-Duty Soldiers.
PG  - 869-875
LID - 10.1089/neu.2016.4480 [doi]
AB  - Risk factors for concussion in active-duty military service members are poorly 
      understood. The present study examined the association between self-reported 
      concussion history and genetics (apolipoprotein E [APOE], brain-derived 
      neurotrophic factor [BDNF], and D2 dopamine receptor genes [DRD2]), trait 
      personality measures (impulsive-sensation seeking and trait 
      aggression-hostility), and current alcohol use. The sample included 458 soldiers 
      who were preparing to deploy for Operation Iraqi Freedom/Operation Enduring 
      Freedom. For those with the BDNF Met/Met genotype, 57.9% (11/19) had a history of 
      one or more prior concussions, compared with 35.6% (154/432) of those with other 
      BDNF genotypes (p = 0.049, odds ratio [OR] = 2.48). APOE and DRD2 genotypes were 
      not associated with risk for past concussions. Those with the BDNF Met/Met 
      genotype also reported greater aggression and hostility personality 
      characteristics. When combined in a predictive model, prior military deployments, 
      being male, and having the BDNF Met/Met genotype were independently associated 
      with increased lifetime history of concussions in active-duty soldiers. 
      Replication in larger independent samples is necessary to have more confidence in 
      both the positive and negative genetic associations reported in this study.
FAU - Dretsch, Michael N
AU  - Dretsch MN
AD  - 1 United States Army Aeromedical Research Laboratory , Fort Rucker, Alabama.
AD  - 2 Human Dimension Division (HDD), Headquarters Army Training and Doctrine Command 
      (HQ TRADOC) , Fort Eustis, Virginia.
FAU - Silverberg, Noah
AU  - Silverberg N
AD  - 3 Division of Physical Medicine and Rehabilitation, University of British 
      Columbia , Vancouver, British Columbia, Canada .
AD  - 4 GF Strong Rehabilitation Centre , Vancouver, British Columbia, Canada .
AD  - 5 Roskamp Institute , Sarasota, Florida.
FAU - Gardner, Andrew J
AU  - Gardner AJ
AD  - 6 Hunter New England Local Health District Sports Concussion Program and Centre 
      for Stroke and Brain Injury, School of Medicine and Public Health, University of 
      Newcastle , Newcastle, NSW, Australia .
FAU - Panenka, William J
AU  - Panenka WJ
AD  - 7 Department of Psychiatry, University of British Columbia , Vancouver, British 
      Columbia, Canada .
FAU - Emmerich, Tanja
AU  - Emmerich T
AD  - 5 Roskamp Institute , Sarasota, Florida.
FAU - Crynen, Gogce
AU  - Crynen G
AD  - 5 Roskamp Institute , Sarasota, Florida.
FAU - Ait-Ghezala, Ghania
AU  - Ait-Ghezala G
AD  - 5 Roskamp Institute , Sarasota, Florida.
FAU - Chaytow, Helena
AU  - Chaytow H
AD  - 5 Roskamp Institute , Sarasota, Florida.
FAU - Mathura, Venkat
AU  - Mathura V
AD  - 5 Roskamp Institute , Sarasota, Florida.
FAU - Crawford, Fiona C
AU  - Crawford FC
AD  - 5 Roskamp Institute , Sarasota, Florida.
FAU - Iverson, Grant L
AU  - Iverson GL
AD  - 8 Department of Physical Medicine and Rehabilitation, Harvard Medical School , 
      Boston, Massachusetts.
AD  - 9 Spaulding Rehabilitation Hospital and Home Base, Red Sox Foundation and 
      Massachusetts General Hospital Home Base Program , Boston, Massachusetts.
AD  - 10 Defense and Veterans Brain Injury Center , Bethesda, Maryland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20160801
PL  - United States
TA  - J Neurotrauma
JT  - Journal of neurotrauma
JID - 8811626
RN  - 0 (ApoE protein, human)
RN  - 0 (Apolipoproteins E)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (DRD2 protein, human)
RN  - 0 (Receptors, Dopamine D2)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Apolipoproteins E/genetics
MH  - *Brain Concussion/epidemiology/genetics/physiopathology
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Humans
MH  - Male
MH  - *Military Personnel
MH  - Personality/*physiology
MH  - Receptors, Dopamine D2/genetics
MH  - Risk Factors
MH  - Sex Factors
MH  - United States/epidemiology
MH  - Young Adult
OTO - NOTNLM
OT  - APOE
OT  - BDNF
OT  - DRD2
OT  - concussion
OT  - genetics
OT  - mild traumatic brain injury
OT  - military
OT  - personality
EDAT- 2016/07/12 06:00
MHDA- 2018/03/02 06:00
CRDT- 2016/07/12 06:00
PHST- 2016/07/12 06:00 [pubmed]
PHST- 2018/03/02 06:00 [medline]
PHST- 2016/07/12 06:00 [entrez]
AID - 10.1089/neu.2016.4480 [doi]
PST - ppublish
SO  - J Neurotrauma. 2017 Feb 15;34(4):869-875. doi: 10.1089/neu.2016.4480. Epub 2016 
      Aug 1.