PMID- 27401475
OWN - NLM
STAT- MEDLINE
DCOM- 20171004
LR  - 20220408
IS  - 1472-6947 (Electronic)
IS  - 1472-6947 (Linking)
VI  - 16
DP  - 2016 Jul 11
TI  - The effect of an interactive weekly mobile phone messaging on retention in 
      prevention of mother to child transmission (PMTCT) of HIV program: study protocol 
      for a randomized controlled trial (WELTEL PMTCT).
PG  - 86
LID - 10.1186/s12911-016-0321-4 [doi]
LID - 86
AB  - BACKGROUND: Improving retention in prevention of mother to child transmission 
      (PMTCT) of HIV programs is critical to optimize maternal and infant health 
      outcomes, especially now that lifelong treatment is immediate regardless of CD4 
      cell count). The WelTel strategy of using weekly short message service (SMS) to 
      engage patients in care in Kenya, where mobile coverage even in poor areas is 
      widespread has been shown to improve adherence to antiretroviral therapy (ART) 
      and viral load suppression among those on ART. The aim of this study is to 
      determine the effect of the WelTel SMS intervention compared to standard care on 
      retention in PMTCT program in Kenya. METHODS: WelTel PMTCT is a four to 
      seven-centers, two-arm open randomized controlled trial (RCT) that will be 
      conducted in urban and rural Kenya. Over 36 months, we plan to recruit 600 
      pregnant women at their first antenatal care visit and follow the mother-infant 
      pair until they are discharged from the PMTCT program (when infant is aged 
      24 months). Participants will be randomly allocated to the intervention or 
      control arm (standard care) at a 1:1 ratio. Intervention arm participants will 
      receive an interactive weekly SMS 'How are you?' to which they are supposed to 
      respond within 24 h. Depending on the response (ok, problem or no answer), a 
      PMTCT nurse will follow-up and triage any problems that are identified. The 
      primary outcome will be retention in care defined as the proportion of 
      mother-infant pairs coming for infant HIV testing at 24 months from delivery. 
      Secondary outcomes include a) adherence to WelTel; (b) adherence to 
      antiretroviral medicine; (c) acceptance of WelTel and (d) cost-effectiveness of 
      the WelTel intervention. DISCUSSION: This trial will provide evidence on the 
      effectiveness of mHealth for PMTCT retention. Trial results and the 
      cost-effectiveness evaluation will be used to inform policy and potential 
      scale-up of mHealth among mothers living with HIV. TRIAL REGISTRATION: 
      ISRCTN98818734 ; registered on 9th December 2014.
FAU - Awiti, Patricia Opondo
AU  - Awiti PO
AD  - Department of Public Health Sciences, Karolinska Institutet, 171 77, Stockholm, 
      Sweden. Patricia.Awiti@ki.se.
FAU - Grotta, Alessandra
AU  - Grotta A
AD  - Department of Medical Epidemiology and Statistics, Karolinska Institutet, 171 77, 
      Stockholm, Sweden.
FAU - van der Kop, Mia
AU  - van der Kop M
AD  - Division of Infectious diseases, University of British Columbia, Vancouver, 
      Canada.
AD  - Division of Global Health, University of British Columbia, Vancouver, Canada.
AD  - Department of Public Health Sciences, 171 77, Stockholm, Sweden.
FAU - Dusabe, John
AU  - Dusabe J
AD  - Department of Public Health Sciences, Karolinska Institutet, 171 77, Stockholm, 
      Sweden.
FAU - Thorson, Anna
AU  - Thorson A
AD  - Department of Public Health Sciences, Karolinska Institutet, 171 77, Stockholm, 
      Sweden.
FAU - Mwangi, Jonathan
AU  - Mwangi J
AD  - Department of Public Health Sciences, Karolinska Institutet, 171 77, Stockholm, 
      Sweden.
FAU - Belloco, Rino
AU  - Belloco R
AD  - Department of Medical Epidemiology and Statistics, Karolinska Institutet, 171 77, 
      Stockholm, Sweden.
FAU - Lester, Richard
AU  - Lester R
AD  - Department of Medicine, University of British Columbia, Vancouver, Canada.
FAU - Ternent, Laura
AU  - Ternent L
AD  - Newcastle University, Tyne and Wear, NE1 7RU, UK.
FAU - Were, Edwin
AU  - Were E
AD  - Department of Reproductive Health, Moi University, P.O.BOX 3900-30100, Eldoret, 
      Kenya.
FAU - Ekstrom, Anna Mia
AU  - Ekstrom AM
AD  - Department of Public Health Sciences, Karolinska Institutet, 171 77, Stockholm, 
      Sweden.
LA  - eng
SI  - ISRCTN/ISRCTN98818734
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20160711
PL  - England
TA  - BMC Med Inform Decis Mak
JT  - BMC medical informatics and decision making
JID - 101088682
RN  - 0 (Anti-Retroviral Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anti-Retroviral Agents/*therapeutic use
MH  - Female
MH  - HIV Infections/*drug therapy/*prevention & control
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Infectious Disease Transmission, Vertical/*prevention & control
MH  - Kenya
MH  - *Medication Adherence
MH  - Telemedicine/*methods
MH  - *Text Messaging
MH  - Young Adult
PMC - PMC4940723
OTO - NOTNLM
OT  - Antiretroviral therapy (ART)
OT  - HIV/PMTCT
OT  - Kenya
OT  - Mobile health (m-health)
OT  - Retention
EDAT- 2016/07/13 06:00
MHDA- 2017/10/05 06:00
PMCR- 2016/07/11
CRDT- 2016/07/13 06:00
PHST- 2016/01/13 00:00 [received]
PHST- 2016/06/08 00:00 [accepted]
PHST- 2016/07/13 06:00 [entrez]
PHST- 2016/07/13 06:00 [pubmed]
PHST- 2017/10/05 06:00 [medline]
PHST- 2016/07/11 00:00 [pmc-release]
AID - 10.1186/s12911-016-0321-4 [pii]
AID - 321 [pii]
AID - 10.1186/s12911-016-0321-4 [doi]
PST - epublish
SO  - BMC Med Inform Decis Mak. 2016 Jul 11;16:86. doi: 10.1186/s12911-016-0321-4.