PMID- 27401570
OWN - NLM
STAT- MEDLINE
DCOM- 20170913
LR  - 20201215
IS  - 1098-6596 (Electronic)
IS  - 0066-4804 (Print)
IS  - 0066-4804 (Linking)
VI  - 60
IP  - 9
DP  - 2016 Sep
TI  - Detectable Tenofovir Levels in Breast-Feeding Infants of Mothers Exposed to 
      Topical Tenofovir.
PG  - 5616-9
LID - 10.1128/AAC.00645-16 [doi]
AB  - Lactation studies are necessary evaluations of medications for reproductive-age 
      women. We evaluated pharmacokinetics (PK), pharmacodynamics, safety, and 
      adherence profiles associated with 7 days of 1% tenofovir (TFV) vaginal gel use 
      during lactation. Tenofovir levels (maternal/infant serum, milk) and anti-HIV 
      activity (milk), adverse events (AEs), and adherence were measured for 17 
      HIV-1-seronegative breast-feeding mother-infant pairs. Tenofovir use was 
      well-tolerated and detected at low levels in maternal serum, milk, and infant 
      serum but demonstrated no anti-HIV activity in milk.
CI  - Copyright (c) 2016, American Society for Microbiology. All Rights Reserved.
FAU - Noguchi, Lisa M
AU  - Noguchi LM
AD  - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 
      Baltimore, Maryland, USA lnoguch1@jhu.edu.
FAU - Montgomery, Elizabeth T
AU  - Montgomery ET
AD  - Women's Global Health Imperative, RTI International, San Francisco, California, 
      USA.
FAU - Biggio, Joseph R
AU  - Biggio JR
AD  - Department of Obstetrics and Gynecology, University of Alabama, Birmingham, 
      Alabama, USA.
FAU - Hendrix, Craig W
AU  - Hendrix CW
AD  - Department of Medicine (Clinical Pharmacology), Johns Hopkins University, 
      Baltimore, Maryland, USA.
FAU - Bogen, Debra L
AU  - Bogen DL
AD  - Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania, 
      USA.
FAU - Hillier, Sharon L
AU  - Hillier SL
AD  - Department of Obstetrics, Gynecology & Reproductive Sciences, University of 
      Pittsburgh, Pittsburgh, Pennsylvania, USA.
FAU - Dai, James Y
AU  - Dai JY
AD  - Statistical Center for HIV/AIDS Research, Fred Hutchinson Cancer Research Center, 
      Seattle, Washington, USA.
FAU - Piper, Jeanna M
AU  - Piper JM
AD  - Division of AIDS/NIAID, U.S. National Institutes of Health, Bethesda, Maryland, 
      USA.
FAU - Marzinke, Mark A
AU  - Marzinke MA
AD  - Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, 
      Maryland, USA.
FAU - Dezzutti, Charlene S
AU  - Dezzutti CS
AD  - Department of Obstetrics, Gynecology & Reproductive Sciences, University of 
      Pittsburgh, Pittsburgh, Pennsylvania, USA.
FAU - Isaacs, S Karen
AU  - Isaacs SK
AD  - Science Facilitation, FHI 360, Durham, North Carolina, USA.
FAU - Schwartz, Jill L
AU  - Schwartz JL
AD  - CONRAD/Eastern Virginia Medical School, Arlington, Virginia, USA.
FAU - Watts, D Heather
AU  - Watts DH
AD  - Maternal and Pediatric Infectious Disease Branch/NICHD/U.S. National Institutes 
      of Health, Bethesda, Maryland, USA.
FAU - Beigi, Richard H
AU  - Beigi RH
AD  - Department of Obstetrics, Gynecology & Reproductive Sciences, University of 
      Pittsburgh, Pittsburgh, Pennsylvania, USA.
LA  - eng
GR  - UM1 AI069494/AI/NIAID NIH HHS/United States
GR  - UM1 AI068633/AI/NIAID NIH HHS/United States
GR  - P30 AI042855/AI/NIAID NIH HHS/United States
GR  - P30 CA015704/CA/NCI NIH HHS/United States
GR  - UM1 AI068615/AI/NIAID NIH HHS/United States
GR  - UM1 AI106707/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20160822
PL  - United States
TA  - Antimicrob Agents Chemother
JT  - Antimicrobial agents and chemotherapy
JID - 0315061
RN  - 0 (Anti-HIV Agents)
RN  - 0 (Vaginal Creams, Foams, and Jellies)
RN  - 99YXE507IL (Tenofovir)
SB  - IM
MH  - Adult
MH  - Anti-HIV Agents/*blood
MH  - Breast Feeding
MH  - Female
MH  - HIV Infections/blood/drug therapy/metabolism
MH  - HIV-1/drug effects
MH  - Humans
MH  - Infant
MH  - Lactation/metabolism
MH  - Milk, Human/*metabolism
MH  - Mothers
MH  - Tenofovir/*blood/*pharmacokinetics/therapeutic use
MH  - Vaginal Creams, Foams, and Jellies/pharmacokinetics/therapeutic use
MH  - Young Adult
PMC - PMC4997886
EDAT- 2016/07/13 06:00
MHDA- 2017/09/14 06:00
PMCR- 2017/03/01
CRDT- 2016/07/13 06:00
PHST- 2016/03/20 00:00 [received]
PHST- 2016/06/26 00:00 [accepted]
PHST- 2017/03/01 00:00 [pmc-release]
PHST- 2016/07/13 06:00 [entrez]
PHST- 2016/07/13 06:00 [pubmed]
PHST- 2017/09/14 06:00 [medline]
AID - AAC.00645-16 [pii]
AID - 00645-16 [pii]
AID - 10.1128/AAC.00645-16 [doi]
PST - epublish
SO  - Antimicrob Agents Chemother. 2016 Aug 22;60(9):5616-9. doi: 10.1128/AAC.00645-16. 
      Print 2016 Sep.