PMID- 27401705
OWN - NLM
STAT- MEDLINE
DCOM- 20170821
LR  - 20170821
IS  - 1873-734X (Electronic)
IS  - 1010-7940 (Linking)
VI  - 51
IP  - 1
DP  - 2017 Jan
TI  - Significance of R1-resection at the bronchial margin after surgery for 
      non-small-cell lung cancer.
PG  - 176-181
LID - 10.1093/ejcts/ezw242 [doi]
AB  - OBJECTIVES: We aimed to evaluate the significance of microscopic residual disease 
      at the bronchial resection margin (R1-BRM) after curative surgery for non-small 
      cell lung cancer (NSCLC). METHODS: Retrospective review was performed on 1800 
      patients from 1994 to 2012. We compared recurrence and survival between 1740 
      patients with R0-resection at the BRM (R0-BRM) and 60 patients with R1-resection 
      at the BRM (R1-BRM), comprising 18 cases of mucosal carcinoma in situ (R1-CIS) 
      and 42 cases of extramucosal residual disease (R1-EMD). RESULTS: Stump recurrence 
      occurred in 43 patients. The 5-year cumulative incidence of stump recurrence in 
      group R0, R1-CIS and R1-EMD was 3.1, 5.6 and 12.2%, respectively. Significant 
      differences of stump recurrence were observed between the groups (R0 versus 
      R1-CIS, P = 0.008; R0 versus R1-EMD, P = 0.007). In Stage IB or II disease, the 
      overall survival rate for R1-EMD was significantly lower than that for R0-BRM (P 
      = 0.014), whereas the difference in overall survival rate between the R1-CIS 
      group and the R0-BRM was not significant (P = 0.37). In Stage IIIA disease, the 
      overall survival rates for R1-CIS (P = 0.87) and R1-EMD (P = 0.45) were not 
      significantly different from that for R0-BRM. CONCLUSIONS: R1-BRM comprises a 
      higher rate of stump recurrence, compared with that of R0-BRM. Herein, R1-EMD was 
      associated with poor overall survival in Stage IB/II disease. In Stage IIIA 
      disease, R1-BRM showed similar overall survival rate to that for R0-BRM, although 
      the number of patients was too small to draw definitive conclusions thereon.
CI  - (c) The Author 2016. Published by Oxford University Press on behalf of the European 
      Association for Cardio-Thoracic Surgery. All rights reserved.
FAU - Lee, Geun Dong
AU  - Lee GD
AD  - Department of Thoracic Surgery, Gangnam Severance Hospital, Yonsei University 
      College of Medicine, Seoul, Republic of Korea.
FAU - Kim, Dong Kwan
AU  - Kim DK
AD  - Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, 
      University of Ulsan College of Medicine, Seoul, Republic of Korea 
      dkkim@amc.seoul.kr.
FAU - Jang, Se Jin
AU  - Jang SJ
AD  - Department of Pathology, Asan Medical Center, University of Ulsan College of 
      Medicine, Seoul, Republic of Korea.
FAU - Choi, Se Hoon
AU  - Choi SH
AD  - Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, 
      University of Ulsan College of Medicine, Seoul, Republic of Korea.
FAU - Kim, Hyeong Ryul
AU  - Kim HR
AD  - Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, 
      University of Ulsan College of Medicine, Seoul, Republic of Korea.
FAU - Kim, Yong-Hee
AU  - Kim YH
AD  - Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, 
      University of Ulsan College of Medicine, Seoul, Republic of Korea.
FAU - Park, Seung-Il
AU  - Park SI
AD  - Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, 
      University of Ulsan College of Medicine, Seoul, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20160711
PL  - Germany
TA  - Eur J Cardiothorac Surg
JT  - European journal of cardio-thoracic surgery : official journal of the European 
      Association for Cardio-thoracic Surgery
JID - 8804069
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Bronchi/pathology/*surgery
MH  - Carcinoma in Situ/mortality/pathology/surgery
MH  - Carcinoma, Non-Small-Cell Lung/mortality/pathology/*surgery
MH  - Child
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/mortality/pathology/*surgery
MH  - Male
MH  - *Margins of Excision
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/epidemiology
MH  - Retrospective Studies
MH  - Young Adult
OTO - NOTNLM
OT  - Lung cancer
OT  - Recurrence
OT  - Surgery
OT  - Survival
EDAT- 2016/07/13 06:00
MHDA- 2017/08/22 06:00
CRDT- 2016/07/13 06:00
PHST- 2016/01/27 00:00 [received]
PHST- 2016/06/02 00:00 [revised]
PHST- 2016/06/08 00:00 [accepted]
PHST- 2016/07/13 06:00 [pubmed]
PHST- 2017/08/22 06:00 [medline]
PHST- 2016/07/13 06:00 [entrez]
AID - ezw242 [pii]
AID - 10.1093/ejcts/ezw242 [doi]
PST - ppublish
SO  - Eur J Cardiothorac Surg. 2017 Jan;51(1):176-181. doi: 10.1093/ejcts/ezw242. Epub 
      2016 Jul 11.