PMID- 27402234
OWN - NLM
STAT- MEDLINE
DCOM- 20180105
LR  - 20220317
IS  - 2047-9980 (Electronic)
IS  - 2047-9980 (Linking)
VI  - 5
IP  - 7
DP  - 2016 Jul 8
TI  - Congenital Heart Disease With and Without Cyanotic Potential and the Long-term 
      Risk of Diabetes Mellitus: A Population-Based Follow-up Study.
LID - 10.1161/JAHA.115.003076 [doi]
LID - e003076
AB  - BACKGROUND: Long-term survival for persons born with congenital heart disease 
      (CHD) is improved, but limited knowledge exists of this growing population's 
      acquired cardiovascular risk profile. This study's purpose was to assess CHD 
      survivors' risk for type 2 diabetes mellitus (T2DM) with attention to the impact 
      of cyanotic CHD. METHODS AND RESULTS: This population-based cohort study included 
      Danish subjects with CHD who were born between 1963 and 1980 and were alive at 
      age 30 years. For each CHD case, we identified 10 individuals from the general 
      population matched by sex and birth year, by using the Danish Civil Registration 
      System. Complete follow-up was obtained through Danish public registries for 
      death, emigration, and T2DM (diagnosis and prescriptions record). We computed 
      cumulative incidences and hazard ratios of developing T2DM after age 30 for 5149 
      CHD subjects compared with the general population. After adjusting for CHD 
      severity, as well as age, sex, preterm birth, and extracardiac defects, we 
      analyzed the impact of cyanotic compared with acyanotic CHD. By age 45 years, the 
      cumulative incidence of T2DM after age 30 was 4% among subjects with CHD. 
      Subjects with CHD were more likely to develop T2DM than the general population 
      (hazard raio 1.4, 95% CI 1.1-1.6). Subjects CHD who had cyanotic defects were 
      more likely to develop T2DM than were subjects with acyanotic CHD (hazard ratio 
      1.9, 95% CI 1.1-3.3). CONCLUSIONS: CHD survivors had an increased risk of 
      developing T2DM after age 30. Patients with cyanotic CHD are at particular risk. 
      Given the cardiovascular health burden of T2DM, attention to its development in 
      CHD survivors seems warranted.
CI  - (c) 2016 The Authors. Published on behalf of the American Heart Association, Inc., 
      by Wiley Blackwell.
FAU - Madsen, Nicolas L
AU  - Madsen NL
AD  - Department of Pediatrics, Heart Institute, University of Cincinnati College of 
      Medicine, Cincinnati, OH nicolas.madsen@cchmc.org.
FAU - Marino, Bradley S
AU  - Marino BS
AD  - Heart Center at the Ann and Robert H. Lurie Children's Hospital of Chicago, 
      Chicago, IL Department of Pediatrics and Medical Social Sciences, Northwestern 
      University Feinberg School of Medicine, Chicago, IL.
FAU - Woo, Jessica G
AU  - Woo JG
AD  - Department of Pediatrics, Heart Institute, University of Cincinnati College of 
      Medicine, Cincinnati, OH Division of Biostatistics and Epidemiology, Department 
      of Pediatrics, Cincinnati Children's Hospital Medical Center, University of 
      Cincinnati College of Medicine, Cincinnati, OH.
FAU - Thomsen, Reimar W
AU  - Thomsen RW
AD  - Department of Clinical Epidemiology, University of Aarhus, Aarhus, Denmark.
FAU - Videboek, Jorgen
AU  - Videboek J
AD  - Department of Clinical Epidemiology, University of Aarhus, Aarhus, Denmark.
FAU - Laursen, Henning Boekgaard
AU  - Laursen HB
AD  - Department of Clinical Epidemiology, University of Aarhus, Aarhus, Denmark.
FAU - Olsen, Morten
AU  - Olsen M
AD  - Department of Clinical Epidemiology, University of Aarhus, Aarhus, Denmark.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160708
PL  - England
TA  - J Am Heart Assoc
JT  - Journal of the American Heart Association
JID - 101580524
SB  - IM
CIN - J Am Heart Assoc. 2016 Jul 08;5(7):. PMID: 27402236
MH  - Adult
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Cyanosis/*epidemiology
MH  - Denmark/epidemiology
MH  - Diabetes Mellitus, Type 2/*epidemiology
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Defects, Congenital/*epidemiology
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Proportional Hazards Models
MH  - Risk Factors
MH  - Severity of Illness Index
PMC - PMC5015361
OTO - NOTNLM
OT  - diabetes mellitus
OT  - epidemiology
OT  - heart defects (congenital)
OT  - hypoxia
EDAT- 2016/07/13 06:00
MHDA- 2018/01/06 06:00
PMCR- 2016/07/01
CRDT- 2016/07/13 06:00
PHST- 2016/07/13 06:00 [entrez]
PHST- 2016/07/13 06:00 [pubmed]
PHST- 2018/01/06 06:00 [medline]
PHST- 2016/07/01 00:00 [pmc-release]
AID - JAHA.115.003076 [pii]
AID - JAH31565 [pii]
AID - 10.1161/JAHA.115.003076 [doi]
PST - epublish
SO  - J Am Heart Assoc. 2016 Jul 8;5(7):e003076. doi: 10.1161/JAHA.115.003076.