PMID- 27403159
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160712
LR  - 20201001
IS  - 1687-6334 (Print)
IS  - 1687-6342 (Electronic)
IS  - 1687-6334 (Linking)
VI  - 2016
DP  - 2016
TI  - MDMA Impairs Response to Water Intake in Healthy Volunteers.
PG  - 2175896
LID - 10.1155/2016/2175896 [doi]
LID - 2175896
AB  - Hyponatremia is a serious complication of 3,4-methylenedioxymethamphetamine 
      (MDMA) use. We investigated potential mechanisms in two double-blind, 
      placebo-controlled studies. In Study 1, healthy drug-experienced volunteers 
      received MDMA or placebo alone and in combination with the alpha-1 adrenergic 
      inverse agonist prazosin, used as a positive control to release antidiuretic 
      hormone (ADH). In Study 2, volunteers received MDMA or placebo followed by 
      standardized water intake. MDMA lowered serum sodium but did not increase ADH or 
      copeptin, although the control prazosin did increase ADH. Water loading reduced 
      serum sodium more after MDMA than after placebo. There was a trend for women to 
      have lower baseline serum sodium than men, but there were no significant 
      interactions with drug condition. Combining studies, MDMA potentiated the ability 
      of water to lower serum sodium. Thus, hyponatremia appears to be a significant 
      risk when hypotonic fluids are consumed during MDMA use. Clinical trials and 
      events where MDMA use is common should anticipate and mitigate this risk.
FAU - Baggott, Matthew J
AU  - Baggott MJ
AUID- ORCID: 0000-0003-1000-194X
AD  - Addiction and Pharmacology Research Laboratory, Friends Research Institute, 
      Baltimore, MD 21201, USA.
FAU - Garrison, Kathleen J
AU  - Garrison KJ
AD  - Addiction and Pharmacology Research Laboratory, Friends Research Institute, 
      Baltimore, MD 21201, USA.
FAU - Coyle, Jeremy R
AU  - Coyle JR
AD  - Division of Biostatistics, School of Public Health, University of California, 
      Berkeley, Berkeley, CA 94720, USA.
FAU - Galloway, Gantt P
AU  - Galloway GP
AD  - Addiction and Pharmacology Research Laboratory, Friends Research Institute, 
      Baltimore, MD 21201, USA.
FAU - Barnes, Allan J
AU  - Barnes AJ
AUID- ORCID: 0000-0001-7780-3504
AD  - Chemistry and Drug Metabolism, IRP, National Institute on Drug Abuse, NIH, 
      Baltimore, MD 21224, USA.
FAU - Huestis, Marilyn A
AU  - Huestis MA
AD  - Chemistry and Drug Metabolism, IRP, National Institute on Drug Abuse, NIH, 
      Baltimore, MD 21224, USA.
FAU - Mendelson, John E
AU  - Mendelson JE
AD  - Addiction and Pharmacology Research Laboratory, Friends Research Institute, 
      Baltimore, MD 21201, USA.
LA  - eng
GR  - R01 DA016776/DA/NIDA NIH HHS/United States
GR  - R01 DA017716/DA/NIDA NIH HHS/United States
GR  - UL1 RR024131/RR/NCRR NIH HHS/United States
PT  - Journal Article
DEP - 20160614
PL  - United States
TA  - Adv Pharmacol Sci
JT  - Advances in pharmacological sciences
JID - 101537654
PMC - PMC4923534
EDAT- 2016/07/13 06:00
MHDA- 2016/07/13 06:01
PMCR- 2016/06/14
CRDT- 2016/07/13 06:00
PHST- 2015/12/02 00:00 [received]
PHST- 2016/04/17 00:00 [revised]
PHST- 2016/05/11 00:00 [accepted]
PHST- 2016/07/13 06:00 [entrez]
PHST- 2016/07/13 06:00 [pubmed]
PHST- 2016/07/13 06:01 [medline]
PHST- 2016/06/14 00:00 [pmc-release]
AID - 10.1155/2016/2175896 [doi]
PST - ppublish
SO  - Adv Pharmacol Sci. 2016;2016:2175896. doi: 10.1155/2016/2175896. Epub 2016 Jun 
      14.