PMID- 27403442
OWN - NLM
STAT- MEDLINE
DCOM- 20170531
LR  - 20190723
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2016
DP  - 2016
TI  - Screening of Undiagnosed Hypothyroidism in Elderly Persons with Diabetes 
      according to Age-Specific Reference Intervals for Serum Thyroid Stimulating 
      Hormone and the Impact of Antidiabetes Drugs.
PG  - 1417408
LID - 10.1155/2016/1417408 [doi]
LID - 1417408
AB  - Background. Studies have suggested that hypothyroidism is more frequent in the 
      elderly with diabetes mellitus. However, an adaptation of TSH levels to age 
      should be considered in this assessment. Some antidiabetes drugs reportedly 
      interfere with TSH levels. The objectives of this study were to evaluate the 
      prevalence of undiagnosed hypothyroidism in patients with diabetes and the 
      influence of antidiabetes drugs. Material and Methods. 1160 subjects, 60 years 
      and older (751 with diabetes), were studied; results were compared according to 
      diabetes treatment and with persons without diabetes. TSH, FT4, 
      antithyroperoxidase, fasting glucose, and HbA1c were measured. Results and 
      Discussion. 6.4% of patients with diabetes had hypothyroidism, a higher 
      prevalence compared with persons without diabetes (5.1%), but lower than observed 
      in many studies. The use of age-specific TSH reference interval (RI) could 
      explain this difference. Patients taking metformin (MTF) had TSH (showed in 
      medians) slightly lower (2.8 mU/L) than those not on MTF (3.3 mU/L), p < 0.05. 
      MTF doses influenced TSH levels. Conclusions. The use of specific TSH RI could 
      avoid the misdiagnosis of hypothyroidism in elderly with diabetes. Patients in 
      use of MTF as single drug had lower TSH than those using other medications and 
      persons without diabetes.
FAU - Fontes, Rosita
AU  - Fontes R
AUID- ORCID: 0000-0002-2628-0886
AD  - Hospital Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, 20241260 
      Rio de Janeiro, RJ, Brazil; Diagnosticos da America SA, Rio de Janeiro, RJ, 
      Brazil.
FAU - Teixeira, Patricia de Fatima Dos Santos
AU  - Teixeira Pde F
AD  - Hospital Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, 20241260 
      Rio de Janeiro, RJ, Brazil.
FAU - Vaisman, Mario
AU  - Vaisman M
AD  - Hospital Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, 20241260 
      Rio de Janeiro, RJ, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20160615
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (Hypoglycemic Agents)
RN  - 9002-71-5 (Thyrotropin)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 1/blood/*complications/drug therapy
MH  - Diabetes Mellitus, Type 2/blood/*complications/drug therapy
MH  - Humans
MH  - Hypoglycemic Agents/*therapeutic use
MH  - Hypothyroidism/blood/complications/*diagnosis
MH  - Mass Screening
MH  - Middle Aged
MH  - Reference Values
MH  - Thyrotropin/*blood
PMC - PMC4925962
EDAT- 2016/07/13 06:00
MHDA- 2017/06/01 06:00
PMCR- 2016/06/15
CRDT- 2016/07/13 06:00
PHST- 2016/02/12 00:00 [received]
PHST- 2016/05/05 00:00 [revised]
PHST- 2016/05/23 00:00 [accepted]
PHST- 2016/07/13 06:00 [entrez]
PHST- 2016/07/13 06:00 [pubmed]
PHST- 2017/06/01 06:00 [medline]
PHST- 2016/06/15 00:00 [pmc-release]
AID - 10.1155/2016/1417408 [doi]
PST - ppublish
SO  - J Diabetes Res. 2016;2016:1417408. doi: 10.1155/2016/1417408. Epub 2016 Jun 15.