PMID- 27405364
OWN - NLM
STAT- MEDLINE
DCOM- 20180111
LR  - 20191210
IS  - 1945-2403 (Electronic)
IS  - 0146-4760 (Linking)
VI  - 40
IP  - 7
DP  - 2016 Sep
TI  - ELISA Detection of 30 New Amphetamine Designer Drugs in Whole Blood, Urine and 
      Oral Fluid using Neogen(R) "Amphetamine" and "Methamphetamine/MDMA" Kits.
PG  - 492-7
LID - 10.1093/jat/bkw060 [doi]
AB  - Amphetamine designer drugs are central nervous system stimulants that are widely 
      disseminated in the illegal market. Generally, in forensic laboratories, 
      immunoassay methods are the first line of screening for these types of drugs in a 
      biological specimen (typically blood, urine or oral fluid). In this article, we 
      describe the cross-reactivity profiles of 30 new amphetamine designer drugs, 
      using the Neogen((R)) [Amphetamine Specific and 
      Methamphetamine/3,4-Methylenedioxymethamphetamine (MDMA) assays] drug tests. To 
      assess the potential matrix influence on the response, each assay was tested on 
      whole blood, urine and oral fluid. Concentrations of 10,000 ng/mL were not 
      sufficient to produce a positive response for the majority of the analyzed 
      amphetamines. This clearly demonstrates that, although these kits are extremely 
      effective for the target drugs for which they are intended (amphetamine, 
      methamphetamine and MDMA), they cannot be used to reliably identify the tested 
      designer drugs in real cases, as these concentrations greatly exceed those 
      expected to be found in forensic samples.
CI  - (c) The Author 2016. Published by Oxford University Press. All rights reserved. For 
      Permissions, please email: journals.permissions@oup.com.
FAU - Nieddu, Maria
AU  - Nieddu M
AD  - Dipartimento di Chimica e Farmacia, Universita di Sassari, Via Muroni 23, 07100 
      Sassari, Italy.
FAU - Burrai, Lucia
AU  - Burrai L
AD  - Dipartimento di Chimica e Farmacia, Universita di Sassari, Via Muroni 23, 07100 
      Sassari, Italy lburrai@uniss.it.
FAU - Baralla, Elena
AU  - Baralla E
AD  - Dipartimento di Medicina Veterinaria, Universita di Sassari, Via Vienna 2, 07100 
      Sassari, Italy.
FAU - Pasciu, Valeria
AU  - Pasciu V
AD  - Dipartimento di Medicina Veterinaria, Universita di Sassari, Via Vienna 2, 07100 
      Sassari, Italy.
FAU - Varoni, Maria Vittoria
AU  - Varoni MV
AD  - Dipartimento di Medicina Veterinaria, Universita di Sassari, Via Vienna 2, 07100 
      Sassari, Italy.
FAU - Briguglio, Irene
AU  - Briguglio I
AD  - Dipartimento di Chimica e Farmacia, Universita di Sassari, Via Muroni 23, 07100 
      Sassari, Italy.
FAU - Demontis, Maria Piera
AU  - Demontis MP
AD  - Dipartimento di Medicina Veterinaria, Universita di Sassari, Via Vienna 2, 07100 
      Sassari, Italy.
FAU - Boatto, Gianpiero
AU  - Boatto G
AD  - Dipartimento di Chimica e Farmacia, Universita di Sassari, Via Muroni 23, 07100 
      Sassari, Italy.
LA  - eng
PT  - Journal Article
DEP - 20160711
PL  - England
TA  - J Anal Toxicol
JT  - Journal of analytical toxicology
JID - 7705085
RN  - 0 (Illicit Drugs)
RN  - CK833KGX7E (Amphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Amphetamine/*analysis/blood
MH  - Blood/metabolism
MH  - Enzyme-Linked Immunosorbent Assay/*methods
MH  - Humans
MH  - Illicit Drugs/*analysis/metabolism
MH  - N-Methyl-3,4-methylenedioxyamphetamine/analysis/metabolism
MH  - Saliva/chemistry
MH  - Substance Abuse Detection/*methods
MH  - Urine/chemistry
EDAT- 2016/07/14 06:00
MHDA- 2018/01/13 06:00
CRDT- 2016/07/14 06:00
PHST- 2016/11/06 00:00 [received]
PHST- 2016/04/24 00:00 [accepted]
PHST- 2016/07/14 06:00 [entrez]
PHST- 2016/07/14 06:00 [pubmed]
PHST- 2018/01/13 06:00 [medline]
AID - bkw060 [pii]
AID - 10.1093/jat/bkw060 [doi]
PST - ppublish
SO  - J Anal Toxicol. 2016 Sep;40(7):492-7. doi: 10.1093/jat/bkw060. Epub 2016 Jul 11.