PMID- 27405830
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160714
LR  - 20160713
IS  - 1351-0002 (Print)
IS  - 1351-0002 (Linking)
VI  - 1
IP  - 5
DP  - 1995 Nov
TI  - Biological variability of superoxide dismutase and glutathione peroxidase in 
      blood.
PG  - 331-5
LID - 10.1080/13510002.1995.11747007 [doi]
AB  - The enzymatic antioxidant defences of mammalian cells include copper-zinc 
      superoxide dismutase (SOD)(Cu Zn-SOD; EC 1.15.1.1) which catalyses the 
      dismutation of superoxide anions (O2(.-)) to hydrogen peroxide(H(2), O(2))and a 
      seleno-dependent glutathione peroxidase (GSH-px) (GSH-px; EC 1.11.1.9) which 
      catalyses the degradation of H(2)O(2) to H(2)O and O(2). The measurement of these 
      enzyme activities is often used as a possible biological index of oxidative 
      stress in various clinical conditions. Complete understanding of such information 
      requires knowledge of the random biological fluctuation of the enzyme activity 
      which occurs in each individual. In the present investigation we examined this 
      normal variability in 12 healthy volunteers (four women and eight men) aged 23-45 
      years, over 6 months. The intra-individual coefficients of variation (estimated 
      using analysis of variance techniques) were 15% (SOD) and 13% (GSH-px). The 
      analytical goal for imprecision was achieved for both enzymes, i.e. it was less 
      than one half of the measured intra-individual variation. Both enzymes showed 
      marked individuality, indicating that an individual's reference values are more 
      useful than population-based data. The critical difference required for 
      significant changes in serial results is 45% for SOD and 40% for GSH-px.
FAU - Lux, O
AU  - Lux O
AD  - a Department of Clinical Chemistry , The Prince of Wales/Prince Henry Hospitals , 
      Randwick , N.S.W. Australia.
FAU - Naidoo, D
AU  - Naidoo D
AD  - a Department of Clinical Chemistry , The Prince of Wales/Prince Henry Hospitals , 
      Randwick , N.S.W. Australia.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Redox Rep
JT  - Redox report : communications in free radical research
JID - 9511366
EDAT- 1995/11/01 00:00
MHDA- 1995/11/01 00:01
CRDT- 2016/07/14 06:00
PHST- 2016/07/14 06:00 [entrez]
PHST- 1995/11/01 00:00 [pubmed]
PHST- 1995/11/01 00:01 [medline]
AID - 10.1080/13510002.1995.11747007 [doi]
PST - ppublish
SO  - Redox Rep. 1995 Nov;1(5):331-5. doi: 10.1080/13510002.1995.11747007.