PMID- 27405911
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160714
LR  - 20160713
IS  - 1028-415X (Print)
IS  - 1028-415X (Linking)
VI  - 1
IP  - 1
DP  - 1998
TI  - Opioid Peptides, Adrenocorticotrophic Hormone and Dietary Copper Intake in 
      Humans.
PG  - 59-67
LID - 10.1080/1028415X.1998.11747213 [doi]
AB  - Copper plays an important role in cardiac and brain function possibly through 
      endocrine and neuroendocrine systems. The syndrome of copper deficiency is 
      worsened by dietary fructose and other trace metals such as zinc. We investigated 
      the effect of a low copper diet on plasma opioid peptides in 11 healthy young 
      volunteers who were fed foods low in copper but adequate in all other nutrients. 
      The study was divided into three dietary periods. Copper was added to the diet so 
      that the diet contained 0.66 mg/day for 24 days (marginal Cu), 0.38 mg/day for 42 
      days (low Cu) and 2.49 mg/day for 24 days (adequate Cu). The indices of copper 
      status, ceruloplasmin and plasma copper concentrations, declined and were 
      significantly lower (p < 0.05) at the end of the low Cu period than at the 
      beginning of the study and the end of the marginal Cu period. They increased 
      significantly at the end of the adequate Cu diet to the levels of the marginal Cu 
      diet. Plasma beta-endorphin (BEN), Leu-enkephalin (LE), Met-enkephalin (ME) and 
      Adrenocorticotropic hormone (ACTH) were measured by radioimmunoassay at the 
      beginning of the study and at the end of each dietary period. No significant 
      differences were observed in BEN, LE or ME during any of the periods. There were 
      only small increases in LE and ME at the end of marginal and low copper diet 
      periods and no significant changes were observed on copper repletion. Plasma ACTH 
      was significantly lower at the end of low copper compared to baseline value but 
      was not lower after marginal copper. Copper repletion had no significant effect 
      on ACTH. The data show that plasma opioid peptides did not respond significantly 
      to differential copper intake.
FAU - Bhathena, S J
AU  - Bhathena SJ
AD  - a USDA, ARS , Beltsville Human Nutrition Research Center, Phytonutrients 
      Laboratory , Beltsville, MD 20705 , USA.
FAU - Werman, M J
AU  - Werman MJ
AD  - b Department of Food Engineering and Biotechnology , Technion-Israel Institute of 
      Technology , Haifa 32000 , Israel.
FAU - Turnlund, J R
AU  - Turnlund JR
AD  - c Western Human Nutrition Research Center, Agricultural Research Service , San 
      Francisco , CA 94129 , USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nutr Neurosci
JT  - Nutritional neuroscience
JID - 100892202
OTO - NOTNLM
OT  - Low copper diets
OT  - Opioid peptides
OT  - Zinc/copper ratio
EDAT- 1998/01/01 00:00
MHDA- 1998/01/01 00:01
CRDT- 2016/07/14 06:00
PHST- 2016/07/14 06:00 [entrez]
PHST- 1998/01/01 00:00 [pubmed]
PHST- 1998/01/01 00:01 [medline]
AID - 10.1080/1028415X.1998.11747213 [doi]
PST - ppublish
SO  - Nutr Neurosci. 1998;1(1):59-67. doi: 10.1080/1028415X.1998.11747213.