PMID- 27406077
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160714
LR  - 20160713
IS  - 1351-0002 (Print)
IS  - 1351-0002 (Linking)
VI  - 2
IP  - 3
DP  - 1996 Jun
TI  - Maternal cadmium intoxication: effects on fetal brain antioxidant defense 
      parameters.
PG  - 199-204
LID - 10.1080/13510002.1996.11747049 [doi]
AB  - The antioxidant potential of the brain in developing fetuses was assessed at 
      gestational days (GD) 16, 18 and 20 and postnatal day (PND)1. Higher activities 
      of superoxide dismutase (SOD) and glutathione peroxidase (GPx) were noticed 
      during fetal development which were reduced to about half and one-quarter, 
      respectively, at PND 1. Glutathione reductase (GR) activity remained stationary 
      throughout the experiment and the values were very high compared to those 
      reported for weanling rats. In contrast, catalase (CAT) activity increased with 
      development. Glutathione (GSH) and total sulfhydryls (TSH) were maximum in 16-day 
      fetal brains and declined subsequently. Brain lipid peroxidation (LPO) was found 
      to increase with age. A group of animals was exposed to 20 ppm cadmium (Cd) in 
      drinking water from the day of conception up to PND 1. Cd was found to increase 
      the activities of brain SOD, CAT, and GR significantly at all the time intervals. 
      The metal exposure decreased fetal brain GPx at GD 18 and 20, whereas GPx 
      activity declined precipitously in both groups on PND 1. Cd caused both 
      increments and decrements in the GSH and TSH levels (depending on gestational 
      day) and increased the LPO in brain. It may be concluded that the Cd-intoxicated 
      fetal brain undergoes significant changes in antioxidant defense parameters 
      which, overall, may be sufficient to permit near-normal development and prevent 
      substantial oxidant damage.
FAU - Gupta, A
AU  - Gupta A
AD  - a Neurotoxicology Research Group , Industrial Toxicology Research Centre , 
      Lucknow - 226 001 , India.
FAU - Gupta, A
AU  - Gupta A
AD  - a Neurotoxicology Research Group , Industrial Toxicology Research Centre , 
      Lucknow - 226 001 , India.
FAU - Shukla, G S
AU  - Shukla GS
AD  - a Neurotoxicology Research Group , Industrial Toxicology Research Centre , 
      Lucknow - 226 001 , India.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Redox Rep
JT  - Redox report : communications in free radical research
JID - 9511366
EDAT- 1996/06/01 00:00
MHDA- 1996/06/01 00:01
CRDT- 2016/07/14 06:00
PHST- 2016/07/14 06:00 [entrez]
PHST- 1996/06/01 00:00 [pubmed]
PHST- 1996/06/01 00:01 [medline]
AID - 10.1080/13510002.1996.11747049 [doi]
PST - ppublish
SO  - Redox Rep. 1996 Jun;2(3):199-204. doi: 10.1080/13510002.1996.11747049.