PMID- 27408805
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160713
LR  - 20201001
IS  - 2213-3232 (Print)
IS  - 2213-3232 (Electronic)
IS  - 2213-3232 (Linking)
VI  - 6
DP  - 2016
TI  - Nonconvulsive status epilepticus cases arising in connection with cephalosporins.
PG  - 23-7
LID - 10.1016/j.ebcr.2016.04.005 [doi]
AB  - Cephalosporins, particularly cefepime, exert neurotoxic side effects that can 
      lead to status epilepticus. These neurotoxic side effects include myoclonus, 
      dystonic movements, tremor, asterixis, seizure, status epilepticus, 
      encephalopathy, and sometimes coma. Status epilepticus, particularly 
      nonconvulsive status epilepticus (NCSE), is a well-known but unusual complication 
      in patients with altered renal function who were receiving treatment with 
      intravenous cephalosporins, especially cefepime. We reviewed the clinical and 
      electroencephalographic (EEG) characteristics of 7 patients with renal failure 
      who developed consciousness alterations with changes in EEG activity while being 
      treated with cephalosporins. All patients developed renal failure: six patients 
      had chronic renal failure, one patient had acute renal failure, and two patients 
      were administered hemodialysis. Nonconvulsive status epilepticus was observed 
      between 2 and 8 days (average of 5.6 days) after initiation of cephalosporins. 
      Cephalosporins are epileptogenic drugs, especially when used in excessive doses 
      or when renal function is impaired. Critically ill patients with chronic kidney 
      disease are particularly susceptible to cefepime neurotoxicity. Clinical and 
      electrophysiological results of patients guide the diagnosis of NCSE by 
      healthcare providers.
FAU - Bora, Ibrahim
AU  - Bora I
AD  - Uludag University Medical School, Neurology Department, 16059 Gorukle, Bursa, 
      Turkey.
FAU - Demir, Aylin Bican
AU  - Demir AB
AD  - Uludag University Medical School, Neurology Department, 16059 Gorukle, Bursa, 
      Turkey.
FAU - Uzun, Pinar
AU  - Uzun P
AD  - Uludag University Medical School, Neurology Department, 16059 Gorukle, Bursa, 
      Turkey.
LA  - eng
PT  - Journal Article
DEP - 20160520
PL  - United States
TA  - Epilepsy Behav Case Rep
JT  - Epilepsy & behavior case reports
JID - 101614202
PMC - PMC4925880
OTO - NOTNLM
OT  - Cephalosporin
OT  - Nonconvulsive status epilepticus
OT  - Prognosis
OT  - Treatment
EDAT- 2016/07/14 06:00
MHDA- 2016/07/14 06:01
PMCR- 2016/05/20
CRDT- 2016/07/14 06:00
PHST- 2016/03/28 00:00 [received]
PHST- 2016/04/11 00:00 [revised]
PHST- 2016/04/30 00:00 [accepted]
PHST- 2016/07/14 06:00 [entrez]
PHST- 2016/07/14 06:00 [pubmed]
PHST- 2016/07/14 06:01 [medline]
PHST- 2016/05/20 00:00 [pmc-release]
AID - S2213-3232(16)30019-6 [pii]
AID - 10.1016/j.ebcr.2016.04.005 [doi]
PST - epublish
SO  - Epilepsy Behav Case Rep. 2016 May 20;6:23-7. doi: 10.1016/j.ebcr.2016.04.005. 
      eCollection 2016.