PMID- 27408877
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160713
LR  - 20201001
IS  - 2322-5718 (Print)
IS  - 2322-5726 (Electronic)
IS  - 2322-5718 (Linking)
VI  - 3
IP  - 1
DP  - 2015 Winter
TI  - (11)C-Choline and FDG PET/CT Imaging of Primary Cholangiocarcinoma: A Comparative 
      Analysis.
PG  - 18-25
AB  - OBJECTIVES: This study aimed to compare the diagnostic values of (11)C-choline 
      and (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed 
      tomography (PET/CT) in patients with cholangiocarcinoma (CCA). METHODS: This 
      prospective study was conducted on 10 patients (6 males and 4 females), aged 
      42-69 years, suspected of having CCA based on CT or magnetic resonance imaging 
      (MRI) results. (11)C-choline and (18)F-FDG PET/CT studies were performed in all 
      patients over 1 week. PET/CT results were visually analyzed by 2 independent 
      nuclear medicine physicians and quantitatively by calculating the 
      tumor-to-background ratio (T/B). RESULTS: No (11)C-choline PET/CT uptake was 
      observed in primary extrahepatic or intrahepatic CCA cases. Intense (18)F-FDG 
      avidity was detected in the tumors of 8 patients (%80). Two patients, who were 
      (18)F-FDG negative, had primary extrahepatic CCA. Ki-67 measurements were 
      positive in all patients (range; 14.2%-39.9%). The average T/B values of 
      (11)C-choline and (18)F-FDG were 0.4+/-0.2 and 2.0+/-1.0 in all cases of primary CCA, 
      respectively; these values were significantly lower for (11)C-choline (P<0.005). 
      Both FDG and (11)C-choline PET/CT detected metastatic CCA foci in all 8 patients 
      (two patients had no metastases). CONCLUSION: As the results suggested, primary 
      CCA lesions showed a poor avidity for (11)C-choline, whereas (18)F-FDG PET/CT was 
      of value for the detection of most primary CCA cases. In contrast to primary 
      lesions, metastatic CCA lesions showed (11)C-choline avidity.
FAU - Chotipanich, Chanisa
AU  - Chotipanich C
AD  - National Cyclotron and PET Centre, Chulabhorn Hospital, Thailand.
FAU - Promteangtrong, Chetsadaporn
AU  - Promteangtrong C
AD  - National Cyclotron and PET Centre, Chulabhorn Hospital, Thailand.
FAU - Kunawudhi, Anchisa
AU  - Kunawudhi A
AD  - National Cyclotron and PET Centre, Chulabhorn Hospital, Thailand.
FAU - Chanwat, Rawisak
AU  - Chanwat R
AD  - Surgery Department, Chulabhorn Hospital, Thailand.
FAU - Sricharunrat, Thaniya
AU  - Sricharunrat T
AD  - Pathology Department, Chulabhorn Hospital, Thailand.
FAU - Suratako, Savitree
AU  - Suratako S
AD  - National Cyclotron and PET Centre, Chulabhorn Hospital, Thailand.
FAU - Wongsa, Paramest
AU  - Wongsa P
AD  - National Cyclotron and PET Centre, Chulabhorn Hospital, Thailand.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Asia Ocean J Nucl Med Biol
JT  - Asia Oceania journal of nuclear medicine & biology
JID - 101611092
PMC - PMC4937685
OTO - NOTNLM
OT  - Cholangiocarcinoma
OT  - Choline
OT  - FDG
OT  - PET/CT
OT  - Radiotracer
EDAT- 2015/01/01 00:00
MHDA- 2015/01/01 00:01
PMCR- 2015/12/01
CRDT- 2016/07/14 06:00
PHST- 2016/07/14 06:00 [entrez]
PHST- 2015/01/01 00:00 [pubmed]
PHST- 2015/01/01 00:01 [medline]
PHST- 2015/12/01 00:00 [pmc-release]
AID - AOJNMB-3-18 [pii]
PST - ppublish
SO  - Asia Ocean J Nucl Med Biol. 2015 Winter;3(1):18-25.