PMID- 27409331
OWN - NLM
STAT- MEDLINE
DCOM- 20170612
LR  - 20190320
IS  - 1414-431X (Electronic)
IS  - 0100-879X (Print)
IS  - 0100-879X (Linking)
VI  - 49
IP  - 8
DP  - 2016 Jul 11
TI  - Blood levels of pro-inflammatory and anti-inflammatory cytokines during an oral 
      glucose tolerance test in patients with symptoms suggesting reactive 
      hypoglycemia.
LID - S0100-879X2016000800702 [pii]
LID - 10.1590/1414-431X20165195 [doi]
LID - e5195
AB  - We evaluated the impact of postprandial glycemia on blood levels of 
      pro-inflammatory and anti-inflammatory cytokines during an oral glucose tolerance 
      test in non-diabetic patients with symptoms suggesting reactive hypoglycemia. 
      Eleven patients with clinical symptoms suggesting reactive hypoglycemia received 
      an oral glucose solution (75 g) Blood was collected at 0 (baseline), 30, 60, 120 
      and 180 min after glucose ingestion and the plasma concentrations of interferon-alpha 
      (IFN-alpha), interferon-gamma (IFN-gamma), interleukin-1 receptor antagonist (IL-1RA), 
      interleukin 2 (IL-2), interleukin-2 receptor (IL-2R), interleukin 4 (IL-4), 
      interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 10 (IL-10), 
      interleukin-12 (IL-12), interleukin 13 (IL-13), interleukin 15 (IL-15), 
      interleukin 17 (IL-17), IFN-gamma inducible protein 10 (IP-10), monocyte chemotactic 
      protein 1 (MCP1), monokine induced by IFN-gamma (MIG), macrophage inflammatory 
      protein-1alpha (MIP-1alpha), interleukin-1beta (IL-1beta), colony stimulating factor (G-CSF), 
      granulocyte-macrophage CSF (GM-CSF), basic fibroblast growth factor (FGF-basic), 
      eotaxin, tumor necrosis factor alpha (TNFalpha), epidermal growth factor (EGF), 
      hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), 
      macrophage inflammatory protein-1alpha (MIP-1alpha), and 1beta (MIP-1beta) were evaluated. 
      Overall, glycemic levels increased, reached its maximum at 30 min (phase 1), 
      returned to baseline levels at 120 min (phase 2), followed by a mild hypoglycemia 
      at 180 min (phase 3). During phase 1, cytokine blood levels were maintained. 
      However, we observed a synchronous fall (P<0.05) in the concentrations of 
      pro-inflammatory (IL-15, IL-17, MCP-1) and anti-inflammatory cytokines 
      (FGF-basic, IL-13, IL-1RA) during phase 2. Furthermore, a simultaneous rise 
      (P<0.05) of pro-inflammatory (IL-2, IL-5, IL-17) and anti-inflammatory cytokines 
      (IL-4, IL-1RA, IL-2R, IL-13, FGF-basic) occurred during phase 3. Thus, mild acute 
      hypoglycemia but not a physiological increase of glycemia was associated with 
      increased blood levels of anti-inflammatory and pro-inflammatory cytokines.
FAU - Eik, W Filho
AU  - Eik W Filho
AD  - Disciplina de Endocrinologia, Departamento de Medicina, Universidade Estadual de 
      Maringa, Maringa, PR, Brasil.
AD  - Programa de Pos Graduacao em Ciencias da Saude, Centro de Ciencias da Saude, 
      Universidade Estadual de Maringa, Maringa, PR, Brasil.
FAU - Marcon, S S
AU  - Marcon SS
AD  - Programa de Pos Graduacao em Ciencias da Saude, Centro de Ciencias da Saude, 
      Universidade Estadual de Maringa, Maringa, PR, Brasil.
AD  - Departamento de Enfermagem, Universidade Estadual de Maringa, Maringa, PR, 
      Brasil.
FAU - Krupek, T
AU  - Krupek T
AD  - Departamento de Farmacologia e Terapeutica, Universidade Estadual de Maringa, 
      Maringa, PR, Brasil.
FAU - Previdelli, I T S
AU  - Previdelli IT
AD  - Departamento de Estatistica, Universidade Estadual de Maringa, Maringa, PR, 
      Brasil.
AD  - Programa de Pos Graduacao em Bioestatistica, Universidade Estadual de Maringa, 
      Maringa, PR, Brasil.
FAU - Pereira, O C N
AU  - Pereira OC
AD  - Departamento de Estatistica, Universidade Estadual de Maringa, Maringa, PR, 
      Brasil.
AD  - Programa de Pos Graduacao em Bioestatistica, Universidade Estadual de Maringa, 
      Maringa, PR, Brasil.
FAU - Silva, M A R C P
AU  - Silva MA
AD  - Departamento de Farmacologia e Terapeutica, Universidade Estadual de Maringa, 
      Maringa, PR, Brasil.
FAU - Bazotte, R B
AU  - Bazotte RB
AD  - Departamento de Farmacologia e Terapeutica, Universidade Estadual de Maringa, 
      Maringa, PR, Brasil.
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Braz J Med Biol Res
JT  - Brazilian journal of medical and biological research = Revista brasileira de 
      pesquisas medicas e biologicas
JID - 8112917
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
RN  - 0 (Insulin)
RN  - 0 (Interleukins)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 103107-01-3 (Fibroblast Growth Factor 2)
RN  - 9008-11-1 (Interferons)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Blood Glucose/*metabolism
MH  - Chemokine CCL2/blood
MH  - Cytokines/*blood/metabolism
MH  - Female
MH  - Fibroblast Growth Factor 2/blood
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Hypoglycemia/*blood
MH  - Inflammation/metabolism
MH  - Insulin/blood
MH  - Interferons/blood
MH  - Interleukins/blood
MH  - Male
MH  - Middle Aged
MH  - Time Factors
MH  - Vascular Endothelial Growth Factor A/blood
PMC - PMC4954733
EDAT- 2016/07/14 06:00
MHDA- 2019/03/21 06:00
PMCR- 2016/07/11
CRDT- 2016/07/14 06:00
PHST- 2015/11/22 00:00 [received]
PHST- 2016/03/31 00:00 [accepted]
PHST- 2016/07/14 06:00 [entrez]
PHST- 2016/07/14 06:00 [pubmed]
PHST- 2019/03/21 06:00 [medline]
PHST- 2016/07/11 00:00 [pmc-release]
AID - S0100-879X2016000800702 [pii]
AID - 10.1590/1414-431X20165195 [doi]
PST - ppublish
SO  - Braz J Med Biol Res. 2016 Jul 11;49(8):e5195. doi: 10.1590/1414-431X20165195.