PMID- 27409470
OWN - NLM
STAT- MEDLINE
DCOM- 20170615
LR  - 20171130
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 57
IP  - 9
DP  - 2016 Jul 1
TI  - Corneal Epithelial Remodeling Induced by Small Incision Lenticule Extraction 
      (SMILE).
PG  - OCT176-83
LID - 10.1167/iovs.15-18879 [doi]
AB  - PURPOSE: To assess the reactive changes of the corneal epithelial thickness (ET) 
      profile induced by small incision lenticule extraction (SMILE) for treatment of 
      myopia. METHODS: This prospective observational study included 46 eyes of 23 
      patients that were scheduled for myopic SMILE. High-resolution spectral-domain 
      optical coherence tomography (SD-OCT) and a custom image segmentation algorithm 
      were applied to measure corneal ET at multiple time points within the central 
      5-mm zone. Postoperative ET alterations were correlated with treatment parameters 
      and refractive outcomes. RESULTS: Mean age was 33 +/- 6 years and mean spherical 
      equivalent of surgical refractive correction was -4.78 +/- 1.75 diopters. The 
      average ET (averaged over the central 5-mm zone) increased from 52.3 +/- 3.6 mum 
      preoperatively to 57.7 +/- 5.1 mum 6 months postoperatively (P < 0.01). Average ET 
      was 101.9% of the preoperative thickness at 24 hours postoperatively, 103.2% at 1 
      week, 106.7% at 6 weeks, 109.3% at 3 months, and 110.4% at 6 months 
      postoperatively. The epithelial thickening response could be modeled by an 
      exponential recovery function and stabilized after 3 months. The extent of 
      epithelial hyperplasia was highly dependent on the magnitude of the induced 
      refractive correction (P = 0.002). CONCLUSIONS: In this initial study of corneal 
      ET remodeling after myopic SMILE, significant epithelial thickening was detected 
      as a function of the extent of surgical refractive correction. Moreover, the 
      epithelial remodeling response to the corneal refractive change appeared to 
      decrease with higher age. In our hands, the observed epithelial changes did not 
      appear to affect the refractive outcome of SMILE. (ClinicalTrials.gov number, 
      NCT02614625).
FAU - Luft, Nikolaus
AU  - Luft N
AD  - Department of Ophthalmology Kepler University Hospital, Johannes Kepler 
      University, Linz, Austria 2Ars Ophthalmica Study Center, Kepler University 
      Hospital, Johannes Kepler University, Linz, Austria.
FAU - Ring, Michael H
AU  - Ring MH
AD  - Ars Ophthalmica Study Center, Kepler University Hospital, Johannes Kepler 
      University, Linz, Austria.
FAU - Dirisamer, Martin
AU  - Dirisamer M
AD  - Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.
FAU - Mursch-Edlmayr, Anna S
AU  - Mursch-Edlmayr AS
AD  - Department of Ophthalmology Kepler University Hospital, Johannes Kepler 
      University, Linz, Austria 2Ars Ophthalmica Study Center, Kepler University 
      Hospital, Johannes Kepler University, Linz, Austria.
FAU - Kreutzer, Thomas C
AU  - Kreutzer TC
AD  - Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.
FAU - Pretzl, Josef
AU  - Pretzl J
AD  - Department of Ophthalmology Kepler University Hospital, Johannes Kepler 
      University, Linz, Austria 2Ars Ophthalmica Study Center, Kepler University 
      Hospital, Johannes Kepler University, Linz, Austria.
FAU - Bolz, Matthias
AU  - Bolz M
AD  - Department of Ophthalmology Kepler University Hospital, Johannes Kepler 
      University, Linz, Austria 2Ars Ophthalmica Study Center, Kepler University 
      Hospital, Johannes Kepler University, Linz, Austria.
FAU - Priglinger, Siegfried G
AU  - Priglinger SG
AD  - Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.
LA  - eng
SI  - ClinicalTrials.gov/NCT02614625
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Adult
MH  - Corneal Surgery, Laser/*methods
MH  - Epithelium, Corneal/*pathology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myopia/diagnosis/physiopathology/*surgery
MH  - Prospective Studies
MH  - *Recovery of Function
MH  - *Refraction, Ocular
MH  - Refractive Surgical Procedures/*methods
MH  - Surgical Flaps
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Acuity
EDAT- 2016/07/15 06:00
MHDA- 2017/06/16 06:00
CRDT- 2016/07/14 06:00
PHST- 2016/07/14 06:00 [entrez]
PHST- 2016/07/15 06:00 [pubmed]
PHST- 2017/06/16 06:00 [medline]
AID - 2534104 [pii]
AID - 10.1167/iovs.15-18879 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2016 Jul 1;57(9):OCT176-83. doi: 
      10.1167/iovs.15-18879.