PMID- 27409477
OWN - NLM
STAT- MEDLINE
DCOM- 20170615
LR  - 20220409
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 57
IP  - 9
DP  - 2016 Jul 1
TI  - OCT-Based Macular Structure-Function Correlation in Dependence on Birth Weight 
      and Gestational Age-the Giessen Long-Term ROP Study.
PG  - OCT235-41
LID - 10.1167/iovs.15-18843 [doi]
AB  - PURPOSE: To compare retinal layer thicknesses in preterm and term-born children 
      using spectral-domain optical coherence tomography (SD-OCT) and to correlate 
      structure with retinal function. METHODS: We performed SD-OCT single and volume 
      scans in the foveal region of premature children aged 6 to 13 years without ROP 
      (no-ROP, n = 100) and with spontaneously regressed ROP (sr-ROP, n = 50) 
      documented with wide-angle digital imaging during routine screening for acute 
      ROP, and 30 age-matched term-born children. Retinal layer segmentation and 
      analysis was performed with custom-made software in single and volume-scans using 
      an Early Treatment of Diabetic Retinopathy Study grid-based method, and compared 
      to light increment sensitivity (LIS) data obtained with a microperimeter at 
      eccentricity points of 0 degrees , 2.8 degrees , and 8 degrees , as previously described. RESULTS: 
      Overall, seven children had to be excluded due to poor image quality (n = 1 
      no-ROP; n = 2 sr-ROP; n = 4 term). Total retina, ganglion cell + inner plexiform 
      layer (GCL+) and outer nuclear layer + external limiting membrane (ONL+) 
      thickness at the foveal center in no-ROP and sr-ROP were significantly higher 
      compared with term children. Gestational age (GA) and birth weight (BW) were 
      inversely correlated with these layer thicknesses. Rod and cone outer segment 
      length did not differ in either group. The ratio of ONL+ to the whole retina at 
      0 degrees  correlated significantly with reduced LIS. CONCLUSIONS: Increased thicknesses 
      of the entire retina or specific layers at the fovea did not correlate with 
      functional loss; but a thinner ONL in retinae without foveal pit did. This 
      reduced ONL+ ratio is potentially caused by a reduced foveal cone density and may 
      be the first morphologic functional correlate in prematurity and ROP.
FAU - Bowl, Wadim
AU  - Bowl W
FAU - Stieger, Knut
AU  - Stieger K
FAU - Bokun, Magdalena
AU  - Bokun M
FAU - Schweinfurth, Silke
AU  - Schweinfurth S
FAU - Holve, Kerstin
AU  - Holve K
FAU - Andrassi-Darida, Monika
AU  - Andrassi-Darida M
FAU - Lorenz, Birgit
AU  - Lorenz B
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Adolescent
MH  - *Birth Weight
MH  - Child
MH  - Female
MH  - Follow-Up Studies
MH  - Fovea Centralis/pathology/physiopathology
MH  - Gestational Age
MH  - Humans
MH  - Infant, Premature
MH  - Macula Lutea/*pathology/physiopathology
MH  - Male
MH  - Retinopathy of Prematurity/*diagnosis/physiopathology
MH  - Term Birth
MH  - Time Factors
MH  - Tomography, Optical Coherence/*methods
MH  - *Visual Acuity
EDAT- 2016/07/15 06:00
MHDA- 2017/06/16 06:00
CRDT- 2016/07/14 06:00
PHST- 2016/07/14 06:00 [entrez]
PHST- 2016/07/15 06:00 [pubmed]
PHST- 2017/06/16 06:00 [medline]
AID - 2534111 [pii]
AID - 10.1167/iovs.15-18843 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2016 Jul 1;57(9):OCT235-41. doi: 
      10.1167/iovs.15-18843.