PMID- 27411854
OWN - NLM
STAT- MEDLINE
DCOM- 20180716
LR  - 20221207
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 6
DP  - 2016 Jul 14
TI  - Two-stage association study to identify the genetic susceptibility of a novel 
      common variant of rs2075290 in ZPR1 to type 2 diabetes.
PG  - 29586
LID - 10.1038/srep29586 [doi]
LID - 29586
AB  - The SNP of rs964184 in ZPR1 has recently been associated with type 2 diabetes 
      mellitus (T2DM) in Japanese individuals. To comprehensively investigate the 
      association of common variants in ZPR1 with T2DM in Han Chinese individuals, we 
      designed a two-stage case-control study of 3,505 T2DM patients and 6,911 
      unrelated healthy Han Chinese individuals. A total of 24 single nucleotide 
      polymorphisms (SNPs) were genotyped, and single-SNP association, imputation and 
      gender-specific association analyses were performed. To increase the coverage of 
      genetic markers, we implemented imputation techniques to extend the number of 
      tested makers to 280. A novel SNP, rs2075290, and the previously reported SNP, 
      rs964184, were significantly associated with T2DM in the two independent 
      datasets, and individuals harboring the CC genotype of rs2075290 and GG genotype 
      of rs964184 exhibited higher levels of fasting plasma glucose (FPG) and blood 
      hemoglobin A1c (HbA1c) than individuals of other genotypes. Additionally, 
      haplotype analyses indicated that two haplotype blocks containing rs2075290 or 
      rs964184 were also significantly associated with T2DM. In summary, these results 
      suggest that ZPR1 plays an important role in the etiology of T2DM, and this gene 
      might be involved in abnormal glucose metabolism.
FAU - Guan, Fanglin
AU  - Guan F
AD  - Health Science Center, Xi'an Jiaotong University, 76 Yanta West Road, Xi'an, 
      China.
FAU - Niu, Yu
AU  - Niu Y
AD  - Department of Endocrinology and Metabolism, Ninth Hospital of Xi'an, 151 Eastern 
      Section of Southern 2nd Ring Road, Xi'an, China.
FAU - Zhang, Tianxiao
AU  - Zhang T
AD  - Division of Biology &Biomedical Sciences, Washington University in Saint Louis, 
      MO, USA.
FAU - Liu, Songfang
AU  - Liu S
AD  - Department of Endocrinology and Metabolism, Ninth Hospital of Xi'an, 151 Eastern 
      Section of Southern 2nd Ring Road, Xi'an, China.
FAU - Ma, Lei
AU  - Ma L
AD  - Department of Endocrinology and Metabolism, Ninth Hospital of Xi'an, 151 Eastern 
      Section of Southern 2nd Ring Road, Xi'an, China.
FAU - Qi, Ting
AU  - Qi T
AD  - Department of Endocrinology and Metabolism, Ninth Hospital of Xi'an, 151 Eastern 
      Section of Southern 2nd Ring Road, Xi'an, China.
FAU - Feng, Jia
AU  - Feng J
AD  - Department of Endocrinology and Metabolism, Ninth Hospital of Xi'an, 151 Eastern 
      Section of Southern 2nd Ring Road, Xi'an, China.
FAU - Zuo, Hong
AU  - Zuo H
AD  - Department of Endocrinology and Metabolism, Ninth Hospital of Xi'an, 151 Eastern 
      Section of Southern 2nd Ring Road, Xi'an, China.
FAU - Li, Guohong
AU  - Li G
AD  - Department of Endocrinology and Metabolism, Ninth Hospital of Xi'an, 151 Eastern 
      Section of Southern 2nd Ring Road, Xi'an, China.
FAU - Liu, Xufeng
AU  - Liu X
AD  - Department of Endocrinology and Metabolism, Ninth Hospital of Xi'an, 151 Eastern 
      Section of Southern 2nd Ring Road, Xi'an, China.
FAU - Wang, Shujin
AU  - Wang S
AD  - Department of Endocrinology and Metabolism, Ninth Hospital of Xi'an, 151 Eastern 
      Section of Southern 2nd Ring Road, Xi'an, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160714
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Carrier Proteins)
RN  - 0 (Membrane Transport Proteins)
RN  - 0 (ZPR1 protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asian People
MH  - Carrier Proteins/*genetics
MH  - Case-Control Studies
MH  - China
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Female
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Membrane Transport Proteins
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
PMC - PMC4944165
EDAT- 2016/07/15 06:00
MHDA- 2018/07/17 06:00
PMCR- 2016/07/14
CRDT- 2016/07/15 06:00
PHST- 2015/08/04 00:00 [received]
PHST- 2016/06/22 00:00 [accepted]
PHST- 2016/07/15 06:00 [entrez]
PHST- 2016/07/15 06:00 [pubmed]
PHST- 2018/07/17 06:00 [medline]
PHST- 2016/07/14 00:00 [pmc-release]
AID - srep29586 [pii]
AID - 10.1038/srep29586 [doi]
PST - epublish
SO  - Sci Rep. 2016 Jul 14;6:29586. doi: 10.1038/srep29586.