PMID- 27412154
OWN - NLM
STAT- MEDLINE
DCOM- 20170214
LR  - 20221207
IS  - 1435-4373 (Electronic)
IS  - 0934-9723 (Linking)
VI  - 35
IP  - 10
DP  - 2016 Oct
TI  - Do HLA class II genes protect against pulmonary tuberculosis? A systematic review 
      and meta-analysis.
PG  - 1567-80
LID - 10.1007/s10096-016-2713-x [doi]
AB  - Pulmonary tuberculosis (PTB) develops by a complex combination of environmental, 
      immunological and socioeconomic factors and genetic susceptibility. The human 
      leukocyte antigen (HLA) is the most polymorphic biological system and plays an 
      essential role in the immune response against PTB. The aim of this study was to 
      carry out a systematic review and meta-analysis evaluating the relationship 
      between HLA-DRB1, HLA-DQB1 and HLA-DQA1 gene polymorphisms as possible risk or 
      protective factors for PTB. A systematic search of the PubMed and Scopus 
      databases was conducted following the guidelines described in the PRISMA 
      statement. Fifty-six alleles were included in the meta-analysis. In the total 
      pooled results, HLA-DRB1*08:03 (OR 1.95, CI 1.29-2.96), HLA-DQB1*06:01 (OR 1.78, 
      CI 1.39-2.28), HLA-DQB1*06:09 (OR 2.27, 95 % CI 1.04-4.96) and HLA-DQA1*01:01 (OR 
      2.12, CI 1.11-4.03) genes were related to higher susceptibility to PTB. 
      Conversely, the presence of the genes HLA-DRB1*07:01 (OR 0.74, CI 0.56-0.97), 
      HLA-DQB1*03:01 (OR 0.77, CI 0.61-0.97), HLA-DQB1*04:02 (OR 0.57, CI 0.39-0.83), 
      HLA-DQA1*04:01 (OR 0.50, CI 0.26-0.95) and HLA-DQA1*05:01 (OR 0.66, CI 0.48-0.92) 
      demonstrated protection against PTB. In an analysis by ethnic subgroups, we found 
      more genetic associations in Caucasians than in Asians. These findings suggest 
      that HLAs may be used as markers for acquisition and development of PTB. To 
      strengthen PTB susceptibility/resistance, we recommend further multicentric 
      studies in different geographic regions, with certainty of controls' exposure to 
      M. tuberculosis by use of marker of latent or active PTB, with analysis 
      stratified by ethnic groups, with descriptions of specific alleles and carrying 
      out immunological functionality tests.
FAU - Oliveira-Cortez, A
AU  - Oliveira-Cortez A
AD  - Graduate Program in Health Sciences, Federal University Sao Joao Del-Rei, 400 
      Sebastiao Goncalves Coelho Avenue, Divinopolis, MG, 35501-296, Brazil.
FAU - Melo, A C
AU  - Melo AC
AD  - Research Core in Epidemiology and Public Health, Federal University Sao Joao 
      Del-Rei, 400 Sebastiao Goncalves Coelho Avenue, Divinopolis, MG, 35501-296, 
      Brazil.
FAU - Chaves, V E
AU  - Chaves VE
AD  - Laboratory of Physiology, Federal University Sao Joao Del-Rei, 400 Sebastiao 
      Goncalves Coelho Avenue, Divinopolis, MG, 35501-296, Brazil.
FAU - Condino-Neto, A
AU  - Condino-Neto A
AD  - Institute of Biomedical Sciences, Department of Immunology, University of Sao 
      Paulo, 1730 Lineu Prestes Avenue, Sao Paulo, SP, 05508-000, Brazil.
FAU - Camargos, P
AU  - Camargos P
AD  - Graduate Program in Health Sciences, Federal University Sao Joao Del-Rei, 400 
      Sebastiao Goncalves Coelho Avenue, Divinopolis, MG, 35501-296, Brazil. 
      paulo.camargos@pq.cnpq.br.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20160713
PL  - Germany
TA  - Eur J Clin Microbiol Infect Dis
JT  - European journal of clinical microbiology & infectious diseases : official 
      publication of the European Society of Clinical Microbiology
JID - 8804297
RN  - 0 (La protein, human)
RN  - 0 (Phosphoproteins)
SB  - IM
MH  - Asian People
MH  - Gene Frequency
MH  - *Genes, MHC Class II
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Mycobacterium tuberculosis/*immunology
MH  - Phosphoproteins/*genetics
MH  - Tuberculosis, Pulmonary/*genetics/immunology
MH  - White People
EDAT- 2016/07/15 06:00
MHDA- 2017/02/15 06:00
CRDT- 2016/07/15 06:00
PHST- 2016/04/18 00:00 [received]
PHST- 2016/06/17 00:00 [accepted]
PHST- 2016/07/15 06:00 [entrez]
PHST- 2016/07/15 06:00 [pubmed]
PHST- 2017/02/15 06:00 [medline]
AID - 10.1007/s10096-016-2713-x [pii]
AID - 10.1007/s10096-016-2713-x [doi]
PST - ppublish
SO  - Eur J Clin Microbiol Infect Dis. 2016 Oct;35(10):1567-80. doi: 
      10.1007/s10096-016-2713-x. Epub 2016 Jul 13.