PMID- 27415789
OWN - NLM
STAT- MEDLINE
DCOM- 20170612
LR  - 20220409
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 57
IP  - 8
DP  - 2016 Jul 1
TI  - Longitudinal Associations Between Microstructural Changes and Microperimetry in 
      the Early Stages of Age-Related Macular Degeneration.
PG  - 3714-22
LID - 10.1167/iovs.15-18294 [doi]
AB  - PURPOSE: To determine whether longitudinal changes in mesopic visual function on 
      microperimetry occurred independent of its associations with microstructural 
      parameters on spectral-domain optical coherence tomography (SD-OCT) in the early 
      stages of AMD. METHODS: Forty-one AMD eyes underwent microperimetry testing and 
      SD-OCT scans over a 12-month period at 6-month intervals. Microstructural 
      parameters analyzed include the retinal pigment epithelium-drusen complex (RPEDC) 
      layer thickness, number of hyperreflective foci (HF) and their inner retinal 
      migration (represented by a weighted axial distribution score; AxD), and the 
      number of atrophic areas. RESULTS: Microperimetric sensitivity was 0.29 dB (95% 
      confidence interval [CI] = -0.38 to -0.20 dB, P < 0.001) and 0.13 dB (95% CI = 
      -0.22 to -0.03 dB, P = 0.008) lower in each sector for every 10-mum higher RPEDC 
      layer thickness and 1-HF present, but was not associated with the AxD score or 
      the number of atrophic areas present (P </= 0.464). However, each 10-mum greater 
      RPEDC layer thickness and 1-HF present was not independently associated with a 
      further decline in sensitivity (-0.08 dB/year, 95% CI = -0.24 to 0.07 dB/year, P 
      = 0.288 and 0.09 dB/year, 95% CI = -0.06 to 0.24 dB/year, P = 0.242, 
      respectively) over time when accounting for the association between RPEDC layer 
      thickness and number of HF with microperimetric sensitivity. CONCLUSIONS: 
      Longitudinal changes in mesopic visual function measured on microperimetry 
      paralleled changes in the microstructural changes over a 12-month time frame, 
      without any changes occurring independent of the associations between structure 
      and function alone.
FAU - Wu, Zhichao
AU  - Wu Z
AD  - Centre for Eye Research Australia University of Melbourne, Royal Victorian Eye 
      and Ear Hospital, Victoria, Australia.
FAU - Cunefare, David
AU  - Cunefare D
AD  - Department of Biomedical Engineering, Duke University, Durham, North Carolina, 
      United States.
FAU - Chiu, Elizabeth
AU  - Chiu E
AD  - Department of Biomedical Engineering, Duke University, Durham, North Carolina, 
      United States.
FAU - Luu, Chi D
AU  - Luu CD
AD  - Centre for Eye Research Australia University of Melbourne, Royal Victorian Eye 
      and Ear Hospital, Victoria, Australia.
FAU - Ayton, Lauren N
AU  - Ayton LN
AD  - Centre for Eye Research Australia University of Melbourne, Royal Victorian Eye 
      and Ear Hospital, Victoria, Australia.
FAU - Toth, Cynthia A
AU  - Toth CA
AD  - Department of Biomedical Engineering, Duke University, Durham, North Carolina, 
      United States 3Department of Ophthalmology, Duke University Medical Center, 
      Durham, North Carolina, United States.
FAU - Farsiu, Sina
AU  - Farsiu S
AD  - Department of Biomedical Engineering, Duke University, Durham, North Carolina, 
      United States 3Department of Ophthalmology, Duke University Medical Center, 
      Durham, North Carolina, United States.
FAU - Guymer, Robyn H
AU  - Guymer RH
AD  - Centre for Eye Research Australia University of Melbourne, Royal Victorian Eye 
      and Ear Hospital, Victoria, Australia.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Aged
MH  - Female
MH  - Humans
MH  - Macular Degeneration/diagnostic imaging/*pathology
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Retinal Drusen/diagnostic imaging/pathology
MH  - Retinal Pigment Epithelium/diagnostic imaging/pathology
MH  - Tomography, Optical Coherence
MH  - Visual Field Tests
EDAT- 2016/07/16 06:00
MHDA- 2019/03/21 06:00
CRDT- 2016/07/15 06:00
PHST- 2016/07/15 06:00 [entrez]
PHST- 2016/07/16 06:00 [pubmed]
PHST- 2019/03/21 06:00 [medline]
AID - 2535252 [pii]
AID - 10.1167/iovs.15-18294 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2016 Jul 1;57(8):3714-22. doi: 10.1167/iovs.15-18294.